Analysis of HCV co-infection with occult hepatitis B virus in patients undergoing IFN therapy

Khattab, Essam Shawky A. E. H.; Chemin, Isabelle; Vuillermoz, Isabelle; Vieux, Claude; Mrani, Saâd; Guillaud, Olivier; Trépo, Christian; Zoulim, Fabien

doi:10.1016/j.jcv.2004.10.016

Cited by 33 publications

(35 citation statements)

References 20 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prevalence of occult HBV infection (7.5%) was similar to a French series of chronic HCV cases that were not related to anti-HBc [12]. In a recent study in Sharqiya governorate of Egypt, the prevalence of occult HBV infection was 3.9% in patients with chronic HCV, 11.1% in anti-HBc positive cases and 2.9% in anti-HBc negative cases [9].…”

Section: Discussionsupporting

confidence: 76%

“…Interestingly, Khattab et al found, mutations in the "a" determinant of the S gene, including the G145R mutation, in all their 4 co-infected patients, which may have explained the lack of detection of serum HBsAg by conventional serology assays [12]. This is consistent with data showing that these mutations may affect the binding of anti-HBs monoclonal antibodies to the "a" determinant of the surface protein [19].…”

Section: Discussionsupporting

confidence: 54%

See 1 more Smart Citation

Genotype characterization of occult hepatitis B virus strains among Egyptian chronic hepatitis C patients

Kishk¹,

Atta²,

Ragheb³

et al. 2014

East Mediterr Health J

View full text Add to dashboard Cite

Chronic hepatitis C virus (HCV) infection combined with occult hepatitis B virus (HBV) infectionhas been associated with increased risk of hepatitis, cirrhosis and hepatocellular carcinoma. This study aimed to determine the prevalence of occult HBV infection among Egyptian chronic HCV patients, the genotype and occurrence of surface gene mutations of HBV and the impact of co-infection on early response to treatment. The study enrolled 162 chronic HCV patients from Ismailia Fever Hospital, Egypt, who were HBV surface antigennegative. All patients were given clinical assessment and biochemical, histological and virological examinations. HBV-DNA was detectable in sera from 3 patients out of the 40 patients who were positive for hepatitis B core antibody. These 3 patients were responsive to combination therapy at treatment week 12; only 1 of them had discontinued therapy by week 24. HBV genotype D was the only detectable genotype in those patients, with absence of "a" determinant mutations among those isolates.

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 54%

Genotype characterization of occult hepatitis B virus strains among Egyptian chronic hepatitis C patients

Kishk¹,

Atta²,

Ragheb³

et al. 2014

East Mediterr Health J

View full text Add to dashboard Cite

show abstract

“…Recently, by using these strict criteria for diagnosing occult HBV, we and others have found that occult HBV coinfection did not seem to result in accelerated fibrosis progression or impaired the response to interferon therapy in chronic HCV-infected immunocompetent patients (17)(18)(19)38). However, whether the same observation still holds true in immunosuppressed chronic HCV patients is uncertain.…”

Section: Discussionmentioning

confidence: 98%

Natural History of Patients with Recurrent Chronic Hepatitis C Virus and Occult Hepatitis B Co-Infection after Liver Transplantation

Hui

Lau

Monto

et al. 2006

American Journal of Transplantation

View full text Add to dashboard Cite

show abstract

“…The role of occult HBV infection in chronic hepatitis C virus (HCV) infection is perhaps the most extensively studied. Cacciola et al (29) not only found higher rates of occult HBV infection among patients with HCV-related chronic liver disease but also found liver cirrhosis more frequently among chronic HCV patients with (76,91,128,133,191,241). Occult HBV infection has been associated with liver enzyme flares during chronic HCV infection (235) without changes in HCV RNA levels (127).…”

Section: Clinical Relevancementioning

confidence: 99%

Molecular Mechanisms Underlying Occult Hepatitis B Virus Infection

2012

View full text Add to dashboard Cite

SUMMARY Chronic hepatitis B virus (HBV) infection is a complex clinical entity frequently associated with cirrhosis and hepatocellular carcinoma (HCC). The persistence of HBV genomes in the absence of detectable surface antigenemia is termed occult HBV infection. Mutations in the surface gene rendering HBsAg undetectable by commercial assays and inhibition of HBV by suppression of viral replication and viral proteins represent two fundamentally different mechanisms that lead to occult HBV infections. The molecular mechanisms underlying occult HBV infections, including recently identified mechanisms associated with the suppression of HBV replication and inhibition of HBV proteins, are reviewed in detail. The availability of highly sensitive molecular methods has led to increased detection of occult HBV infections in various clinical settings. The clinical relevance of occult HBV infection and the utility of appropriate diagnostic methods to detect occult HBV infection are discussed. The need for specific guidelines on the diagnosis and management of occult HBV infection is being increasingly recognized; the aspects of mechanistic studies that warrant further investigation are discussed in the final section.

show abstract

Analysis of HCV co-infection with occult hepatitis B virus in patients undergoing IFN therapy

Cited by 33 publications

References 20 publications

Genotype characterization of occult hepatitis B virus strains among Egyptian chronic hepatitis C patients

Genotype characterization of occult hepatitis B virus strains among Egyptian chronic hepatitis C patients

Natural History of Patients with Recurrent Chronic Hepatitis C Virus and Occult Hepatitis B Co-Infection after Liver Transplantation

Molecular Mechanisms Underlying Occult Hepatitis B Virus Infection

Contact Info

Product

Resources

About