Analysis of heart rate variability using fuzzy measure entropy

Liu, Chengyu; Li, Ké; Zhao, Lina; Liu, Feng; Zheng, Dingchang; Liu, Shutang

doi:10.1016/j.compbiomed.2012.11.005

Cited by 128 publications

(131 citation statements)

References 18 publications

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“…The fuzzy function-based entropy methods were proposed as they are less sensitive to drift in the RR time series because the mean is subtracted from the time series leading to more stable results [35,39,55]. Herein, the MSE_dRR analysis has a similar effect with the fuzzy function-based entropy methods and gives new insight for entropy applications.…”

Section: Discussionmentioning

confidence: 86%

“…In addition, previous studies have shown that the drift in RR intervals can disturb the SampEn computation [24,39], and thus result in the poor SampEn statistical stability [35,54,55]. The fuzzy function-based entropy methods were proposed as they are less sensitive to drift in the RR time series because the mean is subtracted from the time series leading to more stable results [35,39,55].…”

Section: Discussionmentioning

confidence: 99%

“…Existing entropy-based CHF studies include: Liu et al reported decrease of ApEn values in CHF group [34]. Liu et al also developed a fuzzy measure entropy (FuzzyMEn) method for the normal/CHF classification [35]. Zhao et al systematically compared the effects of entropy parameters on CHF identification [36].…”

Section: Introductionmentioning

confidence: 99%

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Multiscale Entropy Analysis of the Differential RR Interval Time Series Signal and Its Application in Detecting Congestive Heart Failure

Liu

Gao

2017

Entropy

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Cardiovascular systems essentially have multiscale control mechanisms. Multiscale entropy (MSE) analysis permits the dynamic characterization of the cardiovascular time series for both short-term and long-term processes, and thus can be more illuminating. The traditional MSE analysis for heart rate variability (HRV) is performed on the original RR interval time series (named as MSE_RR). In this study, we proposed an MSE analysis for the differential RR interval time series signal, named as MSE_dRR. The motivation of using the differential RR interval time series signal is that this signal has a direct link with the inherent non-linear property of electrical rhythm of the heart. The effectiveness of the MSE_RR and MSE_dRR were tested and compared on the long-term MIT-Boston's Beth Israel Hospital (MIT-BIH) 54 normal sinus rhythm (NSR) and 29 congestive heart failure (CHF) RR interval recordings, aiming to explore which one is better for distinguishing the CHF patients from the NSR subjects. Four RR interval length for analysis were used (N = 500, N = 1000, N = 2000 and N = 5000). The results showed that MSE_RR did not report significant differences between the NSR and CHF groups at several scales for each RR segment length type (Scales 7, 8 and 10 for N = 500, Scales 3 and 10 for N = 1000, Scales 2 and 3 for both N = 2000 and N = 5000). However, the new MSE_dRR gave significant separation for the two groups for all RR segment length types except N = 500 at Scales 9 and 10. The area under curve (AUC) values from the receiver operating characteristic (ROC) curve were used to further quantify the performances. The mean AUC of the new MSE_dRR from Scales 1-10 are 79.5%, 83.1%, 83.5% and 83.1% for N = 500, N = 1000, N = 2000 and N = 5000, respectively, whereas the mean AUC of MSE_RR are only 68.6%, 69.8%, 69.6% and 67.1%, respectively. The five-fold cross validation support vector machine (SVM) classifier reports the classification Accuracy (Acc) of MSE_RR as 73.5%, 75.9% and 74.6% for N = 1000, N = 2000 and N = 5000, respectively, while for the new MSE_dRR analysis accuracy was 85.5%, 85.6% and 85.6%. Different biosignal editing methods (direct deletion and interpolation) did not change the analytical results. In summary, this study demonstrated that compared with MSE_RR, MSE_dRR reports better statistical stability and better discrimination ability for the NSR and CHF groups.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Multiscale Entropy Analysis of the Differential RR Interval Time Series Signal and Its Application in Detecting Congestive Heart Failure

Liu

Gao

2017

Entropy

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“…Entropy measures could provide a valuable tool for quantifying the regularity of physiological time series and provide important insights into the underlying mechanisms of the cardiovascular system [19,20]. However, recent studies find ApEn and SampEn measures have poor statistical stability for the HRV analysis [21][22][23], so fuzzy theory-based entropy methods have been developed [7,8,24,25]. We previously proposed a fuzzy measure entropy (FuzzyMEn) method [7,24].…”

Section: Introductionmentioning

confidence: 99%

“…However, recent studies find ApEn and SampEn measures have poor statistical stability for the HRV analysis [21][22][23], so fuzzy theory-based entropy methods have been developed [7,8,24,25]. We previously proposed a fuzzy measure entropy (FuzzyMEn) method [7,24]. The essential difference between the FuzzyMEn and traditional entropy methods is that ApEn and SampEn both use the Heaviside function as the decision rule for vector similarity, whereas FuzzyMEn uses the fuzzy function.…”

Section: Introductionmentioning

confidence: 99%

Effect of a Percutaneous Coronary Intervention Procedure on Heart Rate Variability and Pulse Transit Time Variability: A Comparison Study Based on Fuzzy Measure Entropy

Zhang

Liu

et al. 2016

Entropy

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Percutaneous coronary intervention (PCI) is a common treatment method for patients with coronary artery disease (CAD), but its effect on synchronously measured heart rate variability (HRV) and pulse transit time variability (PTTV) have not been well established. This study aimed to verify whether PCI for CAD patients affects both HRV and PTTV parameters. Sixteen CAD patients were enrolled. Two five-minute ECG and finger photoplethysmography (PPG) signals were recorded, one within 24 h before PCI and another within 24 h after PCI. The changes of RR and pulse transit time (PTT) intervals due to the PCI procedure were first compared. Then, HRV and PTTV were evaluated by a standard short-term time-domain variability index of standard deviation of time series (SDTS) and our previously developed entropy-based index of fuzzy measure entropy (FuzzyMEn). To test the effect of different time series length on HRV and PTTV results, we segmented the RR and PTT time series using four time windows of 200, 100, 50 and 25 beats respectively. The PCI-induced changes in HRV and PTTV, as well as in RR and PTT intervals, are different. PCI procedure significantly decreased RR intervals (before PCI 973˘85 vs. after PCI 907˘100 ms, p < 0.05) while significantly increasing PTT intervals (207˘18 vs. 214˘19 ms, p < 0.01). For HRV, SDTS-only output significant lower values after PCI when time windows are 100 and 25 beats while presenting no significant decreases for other two time windows. By contrast, FuzzyMEn gave significant lower values after PCI for all four time windows (all p < 0.05). For PTTV, SDTS hardly changed after PCI at any time window (all p > 0.90) whereas FuzzyMEn still reported significant lower values (p < 0.05 for 25 beats time window and p < 0.01 for other three time windows). For both HRV and PTTV, with the increase of time window values, SDTS decreased while FuzzyMEn increased. This pilot study demonstrated that the RR interval decreased whereas the PTT interval increased after the PCI procedure and that there were significant reductions in both HRV and PTTV immediately after PCI using the FuzzyMEn method, indicating the changes in underlying mechanisms in cardiovascular system.

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Entropy Analysis in Health Informatics

Humeau-Heurtier

2020

Intelligent Systems Reference Library

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Analysis of heart rate variability using fuzzy measure entropy

Cited by 128 publications

References 18 publications

Multiscale Entropy Analysis of the Differential RR Interval Time Series Signal and Its Application in Detecting Congestive Heart Failure

Multiscale Entropy Analysis of the Differential RR Interval Time Series Signal and Its Application in Detecting Congestive Heart Failure

Effect of a Percutaneous Coronary Intervention Procedure on Heart Rate Variability and Pulse Transit Time Variability: A Comparison Study Based on Fuzzy Measure Entropy

Entropy Analysis in Health Informatics

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