For a certain functional building group, the coupling relationship between the load of a single unit and entire building groups lies in the spatial and temporal patterns personnel distribution. Using the DeST (Designer's Simulation Toolkit) method, the personnel flow trajectory in a university campus in Shanghai was analyzed and the established energy consumption calculation model based on personnel flow trajectory of university buildings. It is proposed that personnel mobility should be included in the application of DeST to predict the total load of building groups. The results show that after the people flow trajectory was included, the total annual accumulated load decreased from 27.01 to 19.39 GWh, reducing by 28.20%; the hourly load fluctuation became more stable, the daily peak load decreased by 22.57%, and the daily peak valley difference decreased by 43.74%. The results suggest that the prediction for the air conditioning load of building complexes would be better when the trajectory of human flow is considered, minimizing unnecessary system scale and investments. Under the "double carbon" policy, the personnel flow trajectory model can effectively reduce waste in air conditioning energy consumption in campus buildings.