Analysis of Hemogram of Radiation Workers in Tangshan, China

Qin, Qian; Cao, Xiaohong; Liu, Haiyan; Shen, Fuhai; Wang, Qian; Tong, Junwang; Qian, Qingqiang

doi:10.1002/jcla.21922

Cited by 8 publications

(8 citation statements)

References 24 publications

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“…36 Another report revealed that the level of RBCs and hemoglobin markedly decreased with longer duration of employment of radiation workers in Tangshan, China. 37 However, in the present study, the males' RBCs and hemoglobin in both sexes did not change with longer length of service. This finding may be due to the different kinds of radiation workers, which included medical staffs and industrial workers in the Tangshan study, whereas the radiation workers in the present study only came from hospital.…”

Section: Discussioncontrasting

confidence: 67%

Analysis of Red Blood Cells and their Components in Medical Workers with Occupational Exposure to Low-Dose Ionizing Radiation

et al. 2022

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Plenty of reports focus on the effects of low-dose radiation (LDR) on peripheral blood lymphocytes in radiation workers. However, studies on red blood cells (RBCs) in radiation workers are rarely reported. Many studies focused on investigate the hemogram of radiation staffs without detecting other components of RBCs. To explore the potential effect of LDR on RBCs, we detected the level of RBC count, hemoglobin, 2,3-disphosphoglycerate (2,3-DPG), and glutathione (GSH), and then analyzed the factors on these indices in 106 medical radiation workers. As a result, RBC count was affected by sex, age, type of work, length of service (only for females), and annual effective dose (only for males). Hemoglobin status was affected by sex, type of work, and annual effective dose (only for males). Sex, age, and type of work had no effects on the concentration of 2,3-DPG and GSH. Length of service affected 2,3-DPG concentration, and annual effective dose affected GSH level. In conclusion, chronic occupational LDR exposure may have an effect on RBC count, hemoglobin status, and the concentration of 2,3-DPG and GSH in radiation workers to some extent. However, it is still unknown how this kind of influence affects the health of radiation workers.

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Section: Discussioncontrasting

confidence: 67%

Analysis of Red Blood Cells and their Components in Medical Workers with Occupational Exposure to Low-Dose Ionizing Radiation

et al. 2022

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“…46 However, with the increase of the cumulative dose, the counts of radiologists such as RBC, WBC, PLT, and HB were significantly decreased, which was partially different from our study. 41 Overall, changes in RBC counts occurred earliest, with a typical turning point at a radiation dose of 2.000 mSv, which was well below the ICRP limit. 12 This result prompted us to focus on how the lowest range of radiation doses affects blood profiles.…”

Section: Discussionmentioning

confidence: 89%

“…It is also worth mentioning that the results of the Tangshan study showed that the type and dose of radiation the radiation workers were exposed to differed among different job types, as did the blood profiles. 41 This suggests that we can explore the correlation between the type of work and the health of radiation workers in the future. Thus, the peripheral blood profiles of workers exposed to long-term low-dose ionizing radiation may be affected by a variety of factors, consistent with the human epidemiological and clinical findings that low-dose ionizing radiation and individual health effects are influenced by demographics, genetics, radiation components, sources, lifestyle, and other environmental exposures.…”

Section: Discussionmentioning

confidence: 99%

Dose-Response Effects of Low-Dose Ionizing Radiation on Blood Parameters in Industrial Irradiation Workers

Guo

Liu

et al. 2022

Dose-Response

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While previous studies have focused on the health effects of occupational exposure of radiations on medical radiation workers, few have analyzed the dose-response relationship between low radiation doses and changes in blood parameters. Even fewer studies have been conducted on industrial worker populations. Using a prospective cohort study design, this study collected health examination reports and personal dose monitoring data from 705 industrial irradiation workers who underwent regular physical examinations at Dongguan Sixth People’s Hospital. The dose-response effects of low-dose ionizing radiation on blood parameters were assessed using a generalized linear model and restricted cubic spline model. Red blood cell counts decreased then increased, before decreasing again with increasing ionizing radiation. This was in contrast to the curve of the total platelet count after irradiation. Additionally, a radiation dose of 2.904 mSv was the turning point for the nonlinear curve of hemoglobin count changes. In conclusion, long-term, low-dose ionizing radiation affects blood cell levels in industrial irradiation workers. There is a nonlinear dose-response relationship between red blood cell, platelet, and hemoglobin counts and the cumulative radiation dose. These findings should alert radiation workers to seek preventive medical treatment before the occurrence of any serious hematopoietic disease.

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“…Changes in the peripheral hemogram might also indicate radiation-induced tissue damage 16,17 ; however, most peripheral blood cells including WBCs and LYMs were not found to significantly differ between the mortality and survival groups. This suggests that the general loss of peripheral blood or immune cells might not be the major reason for lethality.…”

Section: Discussionmentioning

confidence: 98%

Plasma Proteins as Biomarkers of Mortality After Total Body Irradiation in Mice

Xue

et al. 2020

Dose-Response

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During large-scale acute radiation exposure, rapidly distinguishing exposed individuals from nonexposed individuals is necessary. Identifying those exposed to high and potentially lethal radiation doses, and in need of immediate treatment, is especially important. To address this and find plasma biomarkers to assess ionizing radiation-induced mortality in the early stages, mice were administered a whole-body lethal dose of γ radiation, and radiation-induced damage was evaluated. Multiple blood biomarkers were screened using an antibody array, followed by validation using enzyme-linked immunoassay. The results revealed that irradiation (IR)-induced mortality in mice and caused body weight and blood platelet losses in deceased mice compared to surviving mice. The levels of certain proteins differed after IR between these 2 groups. Specific proteins in preirradiated mice were also found to potentiate radiosensitivity. Plasma levels of interleukin (IL)-22, urokinase, resistin, and IL-6 were associated with radiation-induced mortality in irradiated mice and may be useful as potential mortality predictors. Our results suggest that estimating the levels of certain plasma proteins is a promising alternative to conventional cytogenetic biodosimetry to accurately identify individuals exposed to high radiation doses and those at risk of death due to exposure. This strategy would facilitate the rapid triage of individuals requiring immediate and intensive medical treatment.

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Analysis of Hemogram of Radiation Workers in Tangshan, China

Abstract: Long-term IR has some effects on the health of radiation workers, thus protective measures should be further strengthened.

Cited by 8 publications

References 24 publications

Analysis of Red Blood Cells and their Components in Medical Workers with Occupational Exposure to Low-Dose Ionizing Radiation

Analysis of Red Blood Cells and their Components in Medical Workers with Occupational Exposure to Low-Dose Ionizing Radiation

Dose-Response Effects of Low-Dose Ionizing Radiation on Blood Parameters in Industrial Irradiation Workers

Plasma Proteins as Biomarkers of Mortality After Total Body Irradiation in Mice

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