Analysis of herbal bioactives

Ares, Ana M.; Bernal, José; Nozal, Marı́a J.

doi:10.1016/b978-0-12-822716-9.00006-8

Cited by 4 publications

(2 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chlorophylls are tetrapyrrole metabolites that indicates green color present in plants and serves to convert light energy into chemical energy in plants through a process known as photosynthesis (Ares et al, 2021). Chlorophylls have a characteristic central structure similar to the heme structure of hemoglobin constituting blood (Pérez-gálvez et al, 2020).…”

Section: Comparison Of Taste and Nutritional Compounds In Cucumber Fruitmentioning

confidence: 99%

Comparison of Metabolome and Functional Properties of Three Korean Cucumber Cultivars

Son

Lee

2022

Front. Plant Sci.

View full text Add to dashboard Cite

Cucumber (Cucumis sativus L.) is consumed worldwide and various cultivars have been developed to enhance fruit quality. However, few studies have comprehensively evaluated the quality of various cultivars. We carried out a metabolomics approach to study the three different cucumber cultivars (Chuichung, White Dadagi, and Mini) and their parts (peel and flesh) coupled with antioxidant activities. The amino acids, sugars, flavonoids, carotenoids, and chlorophylls were upregulated in Mini flesh; however, in the case of peel, they were highly expressed in Chuichung. The highest antioxidant activity was observed in the peel of Chuichung and flesh of Mini. Through correlation analysis between metabolites and antioxidant activity, apigenin and quercetin derivatives, chlorophyll a, chlorophyll b, lutein, α-carotene, and β-carotene were found to be significantly positively correlated with antioxidant activity. To understand the metabolism of these compounds, we performed a comprehensive pathway analysis using a metabolomics approach and analysis of associated gene expression. In secondary metabolism, the expression levels of carotenoid-related genes (15-cis-phytoene synthase and ζ-carotene desaturase) and chlorophyll-related genes (protochlorophyllide reductase and glutamyl-tRNA reductase) were consistent with the metabolome analysis data. Collectively, carotenoid and chlorophyll metabolism were upregulated in Chuichung peel and Mini flesh, which had the highest antioxidant activity in each part. These bioactive compounds can be used as biomarkers of commercial cucumber fruit quality. Accordingly, this study offers integrative insights into the quality of different cucumber cultivars and explores valuable metabolites and genes that are helpful in improving quality with functional properties.

show abstract

Section: Comparison Of Taste and Nutritional Compounds In Cucumber Fruitmentioning

confidence: 99%

Comparison of Metabolome and Functional Properties of Three Korean Cucumber Cultivars

Son

Lee

2022

Front. Plant Sci.

View full text Add to dashboard Cite

show abstract

“…Xanthones are cyclic oxygenated compounds that display numerous bioactive properties, including antimicrobial, antitubercular, antitumor, antiviral, and antioxidant properties. Their health-promoting effects are mainly attributed to their tricyclic scaffold [64]. The chemical structures of some xanthone compounds affecting HBV DNA replication are shown in Figure 7.…”

Section: Xanthone Compoundsmentioning

confidence: 99%

Phytomedicines to Target Hepatitis B Virus DNA Replication: Current Limitations and Future Approaches

Sadiea

Sultana

Chaki

et al. 2022

IJMS

View full text Add to dashboard Cite

Hepatitis B virus infection (HBV) is one of the most common causes of hepatitis, and may lead to cirrhosis or hepatocellular carcinoma. According to the World Health Organization (WHO), approximately 296 million people worldwide are carriers of the hepatitis B virus. Various nucleos(t)ide analogs, which specifically suppress viral replication, are the main treatment agents for HBV infection. However, the development of drug-resistant HBV strains due to viral genomic mutations in genes encoding the polymerase protein is a major obstacle to HBV treatment. In addition, adverse effects can occur in patients treated with nucleos(t)ide analogs. Thus, alternative anti-HBV drugs of plant origin are being investigated as they exhibit excellent safety profiles and have few or no side effects. In this study, phytomedicines/phytochemicals exerting significant inhibitory effects on HBV by interfering with its replication were reviewed based on different compound groups. In addition, the chemical structures of these compounds were developed. This will facilitate their commercial synthesis and further investigation of the molecular mechanisms underlying their effects. The limitations of compounds previously screened for their anti-HBV effect, as well as future approaches to anti-HBV research, have also been discussed.

show abstract