Analysis of heterocyclic aromatic amines in foods by gas chromatography–mass spectrometry as their tert.-butyldimethylsilyl derivatives

Casal, Susana; Mendes, Eulália; Fernandes, José O.; Oliveira, M. Beatriz P.P.; Ferreira, Margarida A.

doi:10.1016/j.chroma.2004.03.054

Cited by 68 publications

(42 citation statements)

References 42 publications

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“…8 (Ahn et al 2005;Bermudo et al, 2005 ;Borgen et al, 2004;Busquets et al, 2004Busquets et al, , 2006Busquets et al, , 2008Casal et al, 2004;Cheng et al, 2007;Gerbl et al, 2004;Khan et al, 2008;Lan et al, 2004;Melo et al, 2008;Ni et al, 2008;Oz et al, 2007;Persson et al, 2004;Ristic et al 2004;Salmon et al, 2006;Toribio et al, 2007;Tsen et al, 2006;Warzecha et al, 2004;Wong et al, 2005). The average concentrations of several HCAs in meats cooked using different methods shows that chicken presents the highest concentration of HCAs, and in particular of the amines called DMIP and PhIP, which are structurally related, and the comutagens and neurotoxic amines harman and norharman, which were also found at relative high concentrations in venison.…”

Section: Levels Of Hcas In Foodmentioning

confidence: 99%

Food Borne Carcinogens: A Dead End?

Busquets¹

2012

Carcinogen

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Section: Levels Of Hcas In Foodmentioning

confidence: 99%

Food Borne Carcinogens: A Dead End?

Busquets¹

2012

Carcinogen

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“…The vials were then heated to 100°C for 1 hr to convert hydrogen-bearing functional groups (e.g., OH and NH 2 ) to tert-butyldimethylsilyl (tBDMS) derivatives (MacKenzie et al 1987;Casal et al 2004;Schummer et al 2009). Blank samples were also prepared to using the same protocols in order to identify any background contamination.…”

Section: Gc-msmentioning

confidence: 99%

ICE CHEMISTRY ON OUTER SOLAR SYSTEM BODIES: ELECTRON RADIOLYSIS OF N₂-, CH₄-, AND CO-CONTAINING ICES

Materese

Cruikshank

Sandford

et al. 2015

ApJ

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Radiation processing of the surface ices of outer Solar System bodies may be an important process for the production of complex chemical species. The refractory materials resulting from radiation processing of known ices are thought to impart to them a red or brown color, as perceived in the visible spectral region. In this work, we analyzed the refractory materials produced from the 1.2-keV electron bombardment of low-temperature N 2 -, CH 4 -, and CO-containing ices (100:1:1), which simulates the radiation from the secondary electrons produced by cosmic ray bombardment of the surface ices of Pluto. Despite starting with extremely simple ices dominated by N 2 , electron irradiation processing results in the production of refractory material with complex oxygen-and nitrogenbearing organic molecules. These refractory materials were studied at room temperature using multiple analytical techniques including Fourier-transform infrared spectroscopy, X-ray absorption near-edge structure (XANES) spectroscopy, and gas chromatography coupled with mass spectrometry (GC-MS). Infrared spectra of the refractory material suggest the presence of alcohols, carboxylic acids, ketones, aldehydes, amines, and nitriles. XANES spectra of the material indicate the presence of carboxyl groups, amides, urea, and nitriles, and are thus consistent with the IR data. Atomic abundance ratios for the bulk composition of these residues from XANES analysis show that the organic residues are extremely N-rich, having ratios of N/C ∼ 0.9 and O/C ∼ 0.2. Finally, GC-MS data reveal that the residues contain urea as well as numerous carboxylic acids, some of which are of interest for prebiotic and biological chemistries.

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“…However, in recent years a large number of works based on the use of either liquid chromatography or gas chromatography in combination with mass spectrometry (MS) have been published (Barceló-Barrachina, Moyano, & Galceran, 2004;Barceló-Barrachina, Santos, Puignou, & Galceran, 2005;Barceló-Barrachina et al, 2006;Casal, Mendes, Fernandes, Oliveira, & Ferreira, 2004;Toribio, Moyano, Puignou, & Galceran, 2002;Turesky, Taylor, Schnackenberg, Freeman, & Holland, 2005;Zhang et al, 2008), especially liquid chromatography coupled to mass spectrometry (LC/MS) have been widely used for HAAs analysis in these complex samples (Toribio et al, 2002;Barceló-Barrachina et al, 2004, 2006Turesky et al, 2005). LC/MS is favoured because it provides both qualitative and quantitative information, without the requirement of analytes derivatization.…”

Section: Introductionmentioning

confidence: 99%

Potential sources of carcinogenic heterocyclic amines in Chinese mutton shashlik

Sun¹,

Zhang²,

Yong³

et al. 2010

Food Chemistry

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a b s t r a c tHeterocyclic amines (HAs) are formed in muscle meat during its cooking under ordinary conditions. In this work, we measured the concentration of 15 kinds of heterocyclic aromatic amines (HAAs) in mutton shashlik which is one of the most popular dishes in China and provided the basis for efforts to quantify dietary exposure to these compounds. Five mutton shashliks bought in market were determined and the concentrations of Harman, Norharman, DMIP, PhIP and AaC were 0.40-1.36, 0.07-0.50, 0.73-65.07, 0.90-25.62, and 0.39-2.13 ng/g, respectively. The mimic experiments have been carried out in an oven to investigate the influence of time, temperature, flavours, and area of heating surface on the formation of HAAs in ground mutton roasted. The levels of HAAs in cooked meat are highly dependent on the cooking time and temperature and increased with the area of heating surface. Meanwhile, flavours have a different impact because of their various characters.

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Analysis of heterocyclic aromatic amines in foods by gas chromatography–mass spectrometry as their tert.-butyldimethylsilyl derivatives

Cited by 68 publications

References 42 publications

Food Borne Carcinogens: A Dead End?

Food Borne Carcinogens: A Dead End?

ICE CHEMISTRY ON OUTER SOLAR SYSTEM BODIES: ELECTRON RADIOLYSIS OF N₂-, CH₄-, AND CO-CONTAINING ICES

Potential sources of carcinogenic heterocyclic amines in Chinese mutton shashlik

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Analysis of heterocyclic aromatic amines in foods by gas chromatography–mass spectrometry as their tert.-butyldimethylsilyl derivatives

Cited by 68 publications

References 42 publications

Food Borne Carcinogens: A Dead End?

Food Borne Carcinogens: A Dead End?

ICE CHEMISTRY ON OUTER SOLAR SYSTEM BODIES: ELECTRON RADIOLYSIS OF N2-, CH4-, AND CO-CONTAINING ICES

Potential sources of carcinogenic heterocyclic amines in Chinese mutton shashlik

Contact Info

Product

Resources

About

ICE CHEMISTRY ON OUTER SOLAR SYSTEM BODIES: ELECTRON RADIOLYSIS OF N₂-, CH₄-, AND CO-CONTAINING ICES