Analysis of HLA-DR2-associated polymorphisms by oligonucleotide hybridization in an Asian Indian population

Nk, Mehra; Verduijn, Willem; Taneja, Veena; Drabbels, Jos J.M.; Singh, Shruti; Giphart, M. J.

doi:10.1016/0198-8859(91)90087-p

Cited by 38 publications

(27 citation statements)

References 24 publications

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“…These investigators did not observe any association between infant susceptibility and resistance to infection and DR polymorphisms. In support of the possibility that inherent limitations of RFLP analysis account for the apparent difference in results are the other observations by these authors that DQA1 *0102 and DQA1 *0103 are associated with seroreversion status since these alleles are reported to be in linkage with the DRB1 *1301 and *1302 alleles (46,47).…”

Section: Resultssupporting

confidence: 61%

Major histocompatibility complex class II DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups: determination by an automated sequence-based typing method.

Winchester

Chen

Rose

et al. 1995

Proc. Natl. Acad. Sci. U.S.A.

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Transmission of human immunodeficiency virus 1 (HIV-1) from an infected women to her offspring during gestation and delivery was found to be influenced by the infant's major histocompatibility complex class II DRBI alleles. Forty-six HIV-infected infants and 63 seroreverting infants, born with passively acquired anti-HIV antibodies but not becoming detectably infected, were typed by an automated nucleotide-sequence-based technique that uses low-resolution PCR to select either the simpler Taq or the more demanding T7 sequencing chemistry. One or more DR13 alleles, including DRBJ*1301, 1302, and 1303, were found in 31.7% of seroreverting infants and 15.2% of those becoming HIV-infected [OR (odds ratio) = 2.6 (95% confidence interval 1.0-6.8); P = 0.048J. This association was influenced by ethnicity, being seen more strongly among the 80 Black and Hispanic children [OR = 4.3 (1.2-16.4); P = 0.023], with the most pronounced effect among Black infants where 7 of 24 seroreverters inherited these alleles with none among 12 HIV-infected infants (Haldane OR = 12.3; P = 0.037). The previously recognized association of DR13 alleles with some situations of long-term nonprogression of HIV suggests that similar mechanisms may regulate both the occurrence of infection and disease progression after infection. Upon examining for residual associations, only the DR2 allele DRBJ*1501 was associated with seroreversion in Caucasoid infants (OR = 24; P = 0.004). Among Caucasoids the DRBJ*03011 allele was positively associated with the occurrence of HIV infection (P = 0.03).

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Section: Resultssupporting

confidence: 61%

Major histocompatibility complex class II DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups: determination by an automated sequence-based typing method.

Winchester

Chen

Rose

et al. 1995

Proc. Natl. Acad. Sci. U.S.A.

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“…As representative example, we present here data on HLA-A2 and B27 and DR2 and DR4. The details have been published separately elsewhere (19)(20)(21)(22)(23).…”

Section: Molecular Studies In Asian Indiansmentioning

confidence: 99%

The HLA genes and their diverse polymorphism

Mehra

2000

Indian J Clin Biochem

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Advanced DNA level studies based on HLA class II sequence analysis have revealed considerable diversity in HLA among Asian Indians. High resolution typing of specific alleles such as DR2 and DR4 in the HLA class II region by PCR-SSP or SSOP hybridization and their associated DR-DQ haplotypes have helped to detect unique haplotypes and novel alleles which have subsequently been confirmed by sequencing. Incidentally, remarkable stability has been maintained in several other DRB1 alleles viz. DR1, DR7, DR9 and DR10. The ARMS-PCR technology has been found to be particularly useful for typing HLA-A, HLA-B and HLA-Cw alleles. These technologies are far superior over serological methods. Our studies have shown remarkable heterogeneity of common HLA-A and B alleles in Asian Indians. Molecular subtyping of HLA-A2 revealed that subtype A*0211 is found only in Indian population and may be the result of selection pressure in this population. Investigations into polymorphism in the HLA-B27 gene revealed that subtypes common both to the western caucasians and orientals occur in the Indian population. It is apparent that the population of the Indian subcontinent, placed as it is between the Caucasoids and Negroids on one hand and Australoids and Mongoloids on the other, provides a rich source of many HLA haplotypes. While the most frequent Caucasian haplotypes occur with a reasonable frequency in Asian Indians, those found predominantly in other ethnic groups (e.g., Australian Aborigines and populations of Oceania, China and Japan) are also detected. Knowledge on this is most important for donor selection during organ and bone marrow transplantation and for designing MHC targeted vaccines in specific diseases.The major histocompatibility complex (MHC) encompasses two major classes of molecules: the MHC class I and class II, both of which appear to have originated from a common ancestor gene. Though only about one thousandth of the total geneme, the HLA system bears extreme degree of functional polymorphism with a nucleotide diversity

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“…DRB1*1501 has been associated with lepromatous leprosy 26,30 whereas DRB1*1502 has been associated with tuberculoid leprosy. 45 The *1501 and *1502 alleles differ from each other by a single amino acid at codon 86. Class II molecules have polymorphic pockets that accommodate the side chains of bound peptides.…”

Section: Class II Regionmentioning

confidence: 99%

Genetics of susceptibility to leprosy

2002

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The ancient disease of leprosy can cause severe disability and disfigurement and is still a major health concern in many parts of the world. Only a subset of those individuals exposed to the pathogen will go on to develop clinical disease and there is a broad clinical spectrum amongst leprosy sufferers. The outcome of infection is in part due to host genes that influence control of the initial infection and the host's immune response to that infection. Identification of the host genes that influence host susceptibility/resistance will enable a greater understanding of disease pathogenesis. In turn, this should facilitate development of more effective therapeutics and vaccines. So far at least a dozen genes have been implicated in leprosy susceptibility and a genome-wide linkage study has lead to the identification of at least one positional candidate. These findings are reviewed here.

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Analysis of HLA-DR2-associated polymorphisms by oligonucleotide hybridization in an Asian Indian population

Cited by 38 publications

References 24 publications

Major histocompatibility complex class II DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups: determination by an automated sequence-based typing method.

Major histocompatibility complex class II DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups: determination by an automated sequence-based typing method.

The HLA genes and their diverse polymorphism

Genetics of susceptibility to leprosy

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