Analysis of human leukocyte antigen (HLA)‐G polymorphism in normal women and in women with recurrent spontaneous abortions

Abbas, Ata; Tripathi, Priya; Naik, Sita; Agrawal, Suraksha

doi:10.1111/j.1365-2370.2004.00487.x

Cited by 66 publications

(54 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with this, G*0102 was first reported by Pook et al [67] and was only identified in a North India female control population with very low frequency (1.2% of 240 chromosomes) [60]. This allele was not detected in African Shona [68], Danish [4], and Brazilian [69] populations, however, shedding some doubt on the true existence of this variant [68,70].…”

Section: Discussionsupporting

confidence: 78%

“…In addition, HLA-G polymorphism has been linked to pathological situations, such as pemphigus vulgaris [52], inflammatory bowel disease [53], sarcoidosis [54], and idiopathic dilated cardiomyopathy [55]. The overall picture emerging from different independent studies is that some HLA-G polymorphism also is associated with complications of pregnancy, such as implantation failure during in vitro fertilization (IVF) [47], recurrent spontaneous abortion (RSA) [56][57][58][59][60][61], and PE [45,62,63]. Nonetheless, some of these associations are controversial.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

Moreau

Contu

Alba³

et al. 2008

Biology of Reproduction

View full text Add to dashboard Cite

Definite causes for several pathologies of pregnancy remain unknown. In light of several recent studies, however, diminished or aberrant HLA-G expression may be associated with certain complication of pregnancy and be linked to HLA-G polymorphism. We analyzed DNA from 60 normal placentas (controls), 140 placentas from miscarriage, 36 placentas from preeclampsia, 76 placentas from fetal hypotrophy, and 34 placentas with hypoxia for variations in coding regions (allelic groups G*0101 to G*0107) and the 14-bp deletion/insertion into the 3'-untranslated region. No statistically significant differences were observed in the distribution of allelic group between pathological placentas and controls with the exception of G*0106 allele frequency in preeclamptic compared with control placentas (21.2% and 6.6%, respectively). A greater frequency of this allele also was observed in the two subgroups of miscarriage and hypoxia compared with that in controls. In addition, presence of the 14-bp sequence was prominent in preeclampsia compared with controls (60.8% vs. 35%, respectively), and homozygotes with deletion were not detected in the pathology. The results suggest that the G*0106 allele, which is coupled with the presence of the 14-bp sequence, contributes and/or is a relevant marker in some specific complications of pregnancy, especially preeclampsia.

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

Moreau

Contu

Alba³

et al. 2008

Biology of Reproduction

View full text Add to dashboard Cite

show abstract

“…In particular the HLA-G 14 bp ins allele decreases mRNA stability [78] and protein production [2,51,[79][80][81]. RSA is associated with the presence of an increased frequency of women heterozygous [82,83] or homozygous for the 14 bp ins allele [OR 2.7; 95% confidencial interval (CI) = 1.1-6.5; p = 0.03] [80,84] in comparison with controls. Hviid et al [84] have shown more RSA women carrying the G*0106 allele (16%), characterized by the presence of the 14 bp insertion, compared to controls (2%).…”

Section: Pathological Conditionsmentioning

confidence: 99%

The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells

Rizzo

Vercammen

Velde

et al. 2010

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

The nonclassical HLA-G molecule is a trophoblast-specific molecule present in almost every pregnancy. It differs from classical HLA class I molecules by the low degree of allelic variants and the high diversity of protein structures. HLA-G is reported to be a tolerogenic molecule that acts on cells of both innate and adaptive immunity. At the maternal-fetal interface HLA-G seems to be responsible largely for the reprogramming of local maternal immune response. This review will focus on the HLA-G gene expression profile in pregnancy, in preimplantation embryos, and in human embryonic stem cells with emphasis on the structural diversity of the HLA-G protein and its potential functional and diagnostic implications.

show abstract

“…Psychological factors [9] and familial predisposition [10] have been claimed as well. Currently, human leukocyte antigen (HLA)-G polymorphism [11], elevated plasma tumor necrosis factor (TNF)-alpha levels [12], and abnormal expression of CD56+ cells by the endometrium [13] have also been related to recurrent spontaneous abortions. Generally, more than one etiologic factor is present in the same case.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the accuracy of hysteroscopy and hysterosalpingography in evaluation of the uterine cavity in patients with recurrent pregnancy loss

et al. 2005

View full text Add to dashboard Cite

The aim of this study was to compare the accuracy of hysteroscopy and hysterosalpingography (HSG) in evaluating the uterine cavity in patients with recurrent pregnancy loss (RPL). One hundred and twenty consecutive patients with a history of RPL were enrolled into this prospective-observational study in the reproductive endocrinology and infertility clinic of a tertiary referral center. Diagnostic office hysteroscopy without anesthesia or sedation, HSG, and diagnostic laparoscopy when indicated were performed in each case. Eighty-five of 120 (70.83%) hysteroscopic studies performed for RPL demonstrated an acquired (55 cases: 64.7%) or congenital (30 cases: 35.3%) intrauterine lesion. Furthermore, several other etiologic factors were also identified in RPL patients with intrauterine lesions. HSG accurately diagnosed an intrauterine defect in only 56 of 85 (65.88%) cases, based on hysteroscopic confirmation. Fifty percent of the cases with incomplete uterine septum were overlooked during HSG. The sensitivity, specificity, positive predictive value, and negative predictive value of HSG were 74.6%, 79.5%, 90.4%, and 54.7%, respectively. There was a single complication (0.83%) due to hysteroscopy. Hysteroscopy is more accurate than HSG in evaluating the uterine cavity in patients with RPL. We recommend it as a routine procedure instead of HSG.

show abstract

Analysis of human leukocyte antigen (HLA)‐G polymorphism in normal women and in women with recurrent spontaneous abortions

Cited by 66 publications

References 28 publications

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells

Comparison of the accuracy of hysteroscopy and hysterosalpingography in evaluation of the uterine cavity in patients with recurrent pregnancy loss

Contact Info

Product

Resources

About