Analysis of IL1B (rs1143627) IL4 (rs2243250), IL6 (rs1800795), IL8 (rs4073), IL10 (rs1800896, rs1800872), IL17A (rs227593) cytokines genes polymorphism and its complex genotypes among Caucasian patients of Western Siberia with primary open-angle glaucoma

Shevchenko, A. V.; Прокофьев, В Ф; Коненков, В. И.; Черных, В. В.; Ермакова, О. В.; Трунов, А. Н.

doi:10.33029/0206-4952-2021-42-3-211-221

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2022

2024

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“…Therefore, it remains a serious medical and social problem throughout the world [1]. There is an assumption that the predisposition to the development of glaucoma is due to polymorphism of the regulatory regions of coding genes that determine the individual level of production of cytokines, chemokines, and growth factors [2,3]. The aim of our study was to conduct a comprehensive bioinformatics analysis of polymorphic regions of the cytokine network genes to identify the relationship between the features of the topology of this network with the development of POAG.…”

Section: Motivation and Aimmentioning

confidence: 99%

832 BGRS/SB-2022 Topology of the associative cytokine gene network in primary open-angle glaucoma

2022

The Thirteenth International Multiconference

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Section: Motivation and Aimmentioning

confidence: 99%

832 BGRS/SB-2022 Topology of the associative cytokine gene network in primary open-angle glaucoma

2022

The Thirteenth International Multiconference

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The investigation of the association of alleles and genotypes of the polymorphic marker T786C of the eNOS gene at various stages of primary open-angle glaucoma

Gavrilova,

Kinkulkina,

Avagyan

et al. 2024

Rossijskij oftalʹmologičeskij žurnal

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Purpose: to study the association of the polymorphic marker T786C of the eNOS gene with various stages of primary open-angle glaucoma (POAG).Materials and methods. Peripheral blood of 90 patients aged 56 to 89 yrs (ave. 71 yrs) with POAG stages I, II, III was tested. DNA was isolated using a set of ribosorbents (Synthol company); subsequently, a real-time PCR reaction was performed on a DT-96 amplifier using the set to determine the polymorphic marker T786C in the eNOS gene.Results. For all groups of patients, the frequency of occurrence of alleles and genotypes was calculated, and the relationship between the emergence of POAG and the presence of an unfavorable polymorphic marker was determined. The main changes were revealed at POAG stages II and III, whilst at stage I no effect of polymorphism T786C of the eNOS gene was observed.Conclusion. For the first time, a comparative assessment was made of the distribution of alleles and genotypes by the polymorphic marker T786C in the eNOS gene of patients with various POAG stages.

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Analysis of IL1B (rs1143627) IL4 (rs2243250), IL6 (rs1800795), IL8 (rs4073), IL10 (rs1800896, rs1800872), IL17A (rs227593) cytokines genes polymorphism and its complex genotypes among Caucasian patients of Western Siberia with primary open-angle glaucoma

Cited by 2 publications

References 2 publications

832 BGRS/SB-2022 Topology of the associative cytokine gene network in primary open-angle glaucoma

832 BGRS/SB-2022 Topology of the associative cytokine gene network in primary open-angle glaucoma

The investigation of the association of alleles and genotypes of the polymorphic marker T786C of the eNOS gene at various stages of primary open-angle glaucoma

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