Analysis of immunostimulatory activity of polysaccharide extracted from Yu-Ping-Feng in vitro and in vivo

Fan, Wentao; Zheng, Pimiao; Wang, Yang; Pān, Hào; Liu, Jianzhu; Zhao, Xiaona

doi:10.1016/j.biopha.2017.05.138

Cited by 27 publications

(16 citation statements)

References 29 publications

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“…Consistent with these previous studies, the results suggested that dietary YPS significantly increased THC of L. vannamei after 14 days of feeding. Evidence showed that YPS can regulate cell cycle progression into S and G2/M phase and promote mitosis [48], which may explain the increased THC in present results. To confirm this hypothesis, experiments such as primary cell cultures merit investigations in future studies.…”

Section: Discussionsupporting

confidence: 56%

“…Among them, plant polysaccharide is widely studied due to its diverse biological activities, including immunostimulatory activity, antiviral activity, antioxidant activity, antitumor activity, radioprotection effect, hepatoprotection effect, and antifatigue effect [47]. And the mixture of three plant polysaccharides (APS, AMP and SPS), YPS, has been elucidated to enhance the immunity and disease resistance of human and livestock [27,32,48]. In present study, effects of dietary YPS on the immune response and intestinal microbiota of shrimp were investigated.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei

Fan

Pan

et al. 2020

Fish & Shellfish Immunology

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei

Fan

Pan

et al. 2020

Fish & Shellfish Immunology

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“…The cell cycle refers to a series of processes that take place in a cell to allow division and duplication period. Research showed that polysaccharide isolated from Yu-Ping-Feng (YPF-PS) could significantly increase lymphocyte cells entering into the S and G2/M phases at most time points by the in vitro and in vivo tests [ 24 ]. Previous reports have shown that Atractylodis macrocephalae Koidz polysaccharides (RAMPS 60c and RAMPS tp ) could promote cells into the S and G2/M phases [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Polysaccharides from Platycodon grandiflorum on Immunity-Enhancing Activity In Vitro

et al. 2017

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The study is aimed at investigating the immunoenhancement activity of polysaccharides from Platycodon grandiflorum polysaccharides (PGPSs) in vitro. In this study, some research on lymphocyte proliferation, cell cycle, and the levels of CD4+ and CD8+ T cells were performed. Four different concentrations of PGPSs (PGPStc, PGPS60c, PGPS80c, and PGPStp) were harvested and added to peripheral blood T lymphocytes. We observed significant increases in T lymphocyte proliferation at PGPStc groups individually or synergistically with phytohemagglutinin (PHA) at most concentrations, and their lymphocyte proliferation rates were the highest. The active sites of PGPStc and PGPS60c were subsequently chosen. Then, we utilized flow cytometry to determine lymphocyte cell cycle distribution and levels of CD4+ and CD8+ T cells. At most time points, PGPStc could facilitate lymphocyte cell cycle progression from the G0/G1 phase to the S and G2/M phases and, simultaneously, increase the levels of CD4+ and CD8+ T cells. These results indicate that PGPStc enhances the immune functions, suggesting that PGPStc could be a potential immunopotentiator for further in vivo and clinical trial experiments.

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“…Additionally, natural products, consisting of intrinsically diverse structures (compared with synthetic compounds), are the main sources of bioactive agents for developing novel medicines [6,7]. Production of drugs from medicinal plants has mostly been dependent upon isolation of materials which are the source of biological activities of the plants [8].…”

Section: Introductionmentioning

confidence: 99%

Pistacia atlantica gum aqueous extract modulates humoral and cellular immune responses in BALB/c mice

Ghaleh¹,

Gandabeh²,

Motlagh³

et al. 2020

Turk J Vet Anim Sci

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Natural herbal products contain different compounds that can modulate immune and inflammatory diseases. This investigation aimed to examine the influence of Pistacia atlantica aqueous extract on cellular and humoral immunity in mice following the exposure to sheep red blood cells (SRBCs). For this purpose, male BALB/c mice (n = 40) were randomly assigned into 4 equivalent groups. The animals received 1 × 10 9 SRBCs in complete Freund's adjuvant (CFA) intraperitoneally 3 times with two-week intervals. Five days after the final injection, blood samples were taken from the animals. Additionally, 1 × 10 9 SRBCs were also injected into the mice's left hind footpad 48 h before the blood collection. Three groups of mice received various oral doses of the extract (100, 200, and 400 mg/kg) for 52 consecutive days after the study onset. Measurements were performed on the levels of humoral and cellular immune responses, splenocytes' ability to uptake neutral red, respiratory burst, and cell viability. The mice receiving Pistacia atlantica in all concentrations displayed significantly low delayed type hypersensitivity (DTH) reactions in a dose-dependent manner compared to the control animals. The treated mice also presented a dose-dependent, significantly lower average anti-SRBC titer than that in the control animals. IL-17 and IL-10 cytokine levels respectively decreased and increased significantly in the mice that received Pistacia atlantica compared to the control group. Splenocyte proliferation and respiratory burst declined significantly in mice treated with Pistacia atlantica as opposed to the normal control group but phagocytosis ability was significantly decreased. The immunomodulatory impacts of Pistacia atlantica might be partially caused by immunity diversion from proinflammatory cytokine IL-17 into antiinflammatory cytokine IL-10.

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Analysis of immunostimulatory activity of polysaccharide extracted from Yu-Ping-Feng in vitro and in vivo

Cited by 27 publications

References 29 publications

Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei

Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei

Effects of Polysaccharides from Platycodon grandiflorum on Immunity-Enhancing Activity In Vitro

Pistacia atlantica gum aqueous extract modulates humoral and cellular immune responses in BALB/c mice

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