Analysis of Indian Population Based on Y-STRs Reveals Existence of Male Gene Flow across Different Language Groups

Saha, Ayan; Udhayasuriyan, P.T.; Bhat, K. V.; Bamezai, R.

doi:10.1089/104454903770946683

Cited by 8 publications

(7 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dravidian speakers, mostly located in South India except a small isolate in the Balochistan province of Pakistan, are a striking example of such a great divergence among populations from this subcontinent, as even close geographic neighbors have clearly distinct genetic profiles. Studies based on the Y chromosome are mostly in agreement with our results, as Indian ethnic groups, castes, and tribes are described as highly differentiated genetically, and genetic drift is likely a major factor in their variation pattern (43–47). However, some of these studies (i.e., by Saha and coworkers, 43, 44) suggest a relatively high degree of genetic admixture and no population isolation in India, while others predict restricted male gene flow in this subcontinent.…”

Section: Discussionsupporting

confidence: 90%

“…Studies based on the Y chromosome are mostly in agreement with our results, as Indian ethnic groups, castes, and tribes are described as highly differentiated genetically, and genetic drift is likely a major factor in their variation pattern (43–47). However, some of these studies (i.e., by Saha and coworkers, 43, 44) suggest a relatively high degree of genetic admixture and no population isolation in India, while others predict restricted male gene flow in this subcontinent. For example, an extensive study based on several Pakistanis ethnic groups concludes that the present Y haplotype distribution in this country is the result of both limited gene flow between populations and genetic drift in the smaller ones (48).…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

HLA‐C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India–Pakistan

et al. 2006

View full text Add to dashboard Cite

Lebanon is located at a continental crossroad between Europe, Africa, and Asia. This region has been the center of wide-scale movements of populations as well as the theater of genetic and cultural trade off among neighboring populations. In this study, HLA-C alleles were characterized by a PCR-SSOP (sequence-specific oligonucleotide probes) hybridization protocol in a sample of 97 Lebanese. A total of 23 alleles were identified with four predominant, Cw*0401, Cw*0602, Cw*0701/06, and Cw*1203, accounting for almost 60% of HLA-C allele frequencies. We included the Lebanese data into a broad analysis of the HLA-C genetic structure of a large set of populations located in Europe, the Middle East, and the Indian subcontinent. Our results indicate that Lebanese exhibit an intermediate genetic profile among the populations from the Middle East, which constitute a rather homogeneous genetic group. In Europe, a high correlation coefficient is found between genetic and geographic distances. In this continent, we also identified a significant genetic frontier following a north-east to south-west axis. This frontier cuts through the Alps and the Pyrenees, thus separating the north-western European populations from those located in the eastern and Mediterranean areas. Finally, the populations from India - Pakistan are very heterogeneous, particularly the Dravidians. Their differentiation has probably been caused by rapid genetic drift under complex influences of cultural, linguistic, and/or religious barriers. Overall, the results show that the HLA-C genetic patterns of these three geographic regions, i.e., the Middle East, Europe, and India-Pakistan, have been shaped by very different genetic histories.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

HLA‐C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India–Pakistan

et al. 2006

View full text Add to dashboard Cite

show abstract

“…This is supported by prehistoric, historic, and linguistic evidences where Middle East/West Asian and Central Asian gene pools have been known to have contributed to the Indian gene pool (Majumder 2001). The calculated diversity for both biallelic markers and Y-STRs strengthened the inference of a strong admixture in Indian populations reported earlier (Saha et al 2003;Saha and Bamezai 2000) and supported by median joining network (Fig. 2).…”

Section: Methodssupporting

confidence: 73%

“…India presents with a pool of genetically and culturally (Cavalli-Sforza et al 1994;Majumder 2001;Saha et al 2003) diverse populations. Where on one hand, minuscule exercises of looking at caste-and region-related population structures have been continuing (Thangaraj et al 1999;Bamshad et al 2001;Kumar and Reddy 2003), the studies of the kind reported earlier and here will continue to add to the pool of information on relatedness of diverse population groups in India.…”

Section: Introductionmentioning

confidence: 99%

Genetic affinity among five different population groups in India reflecting a Y-chromosome gene flow

et al. 2004

Self Cite

View full text Add to dashboard Cite

Four binary polymorphisms and four multiallelic short tandem repeat (STR) loci from the nonrecombining region of the human Y-chromosome were typed in different Indian population groups from Uttar Pradeh (UP), Bihar (BI), Punjab (PUNJ), and Bengal (WB) speaking the Indo-Aryan dialects and from South India (SI) with the root in the Dravidian language. We identified four major haplogroups [(P) 1 + , (C and F) 2 + , (R1a) 3, (K) 26 + ] and 114 combinations of Y-STR haplotypes. Analyses of the haplogroups indicated no single origin from any lineage but a result of a conglomeration of different lineages from time to time. The phylogenetic analyses indicate a high degree of population admixture and a greater genetic proximity for the studied population groups when compared with other world populations.

show abstract

“…A perusal of above given facts makes it possible to conclude, that Khatri population is most probably a result of conglomeration of different lineages like most other North-West Indian populations (Majumder 2001;Saha et al 2003;Saha and Bamezai 2000). The results of this study can only be reinforced by further study with larger sample size as well as more DNA markers.…”

Section: Resultsmentioning

confidence: 62%

Study of DYS 390 Polymorphism among Khatri Population of Punjab in Comparison to Other Indian and World Population

Badaruddoza

Bhanwer

Kaur

et al. 2007

International Journal of Human Genetics

View full text Add to dashboard Cite

The Y chromosome specific polymorphism (Y-STR and Y-SNPs) can be used to track paternal lineages as well as male specific movements and admixture among humans. The objective of the present work is to study the genetic polymorphism at Y chromosome specific STR locus, DYS390 among Khatri population of Punjab and generate a comparative data with respect to other Indian and world populations. The DNA was isolated from blood samples of Khatri male individuals through organic method and were amplified by PCR using specific primers for DYS390 locus. The PCR products were electrophoresed on polyacrylamide gels and silver staining was done to resolve and observe different alleles. Gel-Pro 3.1 software was used to confirm the allele size. Chi-Square test was applied to test whether differences between the allele frequencies among Khatri, other Indian and world populations were statistically significant. Network Joining (NJ) tree was constructed using Network analysis software. The results showed 7 different alleles ranging from 22 to 28 in Khatri population and revealed a significantly high degree of genetic heterogeneity at this locus. The gene diversity was found to be 0.8363. The Network Joining tree showed Khatri population as an independent branch alongside Chinese. Therefore, it can be inferred that Khatri population is probably a result of conglomeration of different lineages, like most other North-West Indian population.

show abstract

Analysis of Indian Population Based on Y-STRs Reveals Existence of Male Gene Flow across Different Language Groups

Cited by 8 publications

References 44 publications

HLA‐C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India–Pakistan

HLA‐C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India–Pakistan

Genetic affinity among five different population groups in India reflecting a Y-chromosome gene flow

Study of DYS 390 Polymorphism among Khatri Population of Punjab in Comparison to Other Indian and World Population

Contact Info

Product

Resources

About