Analysis of inflammasomes and CYP27B1 genes in cuprizone demyelinated C57BL/6 mice and evaluation of Th1 and Th2 patterns after oral administration of Lactobacillus casei strain T2 (IBRC-M10783)

Digehsara, Saeideh Gharekhani; Name, Niloofar; Sartipnia, Nasrin; Karim, Elahe; Taheri, Saba; Ebrahimi, Maryam; Arasteh, Javad

doi:10.1016/j.micpath.2021.104931

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…Moreover, a reduced translocation of NF-kB into the nucleus and increased expression of the TIMP-1 in chondrocytes was observed [ 137 ]. An MS mouse model, with demyelination induced by cuprizone and treated with L. casei strain T2 IBRC-M10783, showed a significant decrease in IFN-γ and IL-4 serum levels compared to the cuprizone group alone [ 138 ].…”

Section: Probiotic Effects On Cytokine/mmp-mediated Signalling Pathwaysmentioning

confidence: 99%

Probiotics as Potential Biological Immunomodulators in the Management of Oral Lichen Planus: What’s New?

Zanetta

Ormelli

Amoruso

et al. 2022

IJMS

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Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory disorder with multifactorial aetiology and malignant transformation potential. Despite the treatments so far identified, new tailored and safe specific measures are needed. Recently, human microbiota imbalance has been linked to several immune-mediated diseases, opening new therapeutic perspectives for probiotics; besides their ability to directly interact with the host microbiota, they also display a strain-specific immune-modulatory effect. Thus, this non-systematic review aims to elucidate the molecular pathways underlying probiotic activity, mainly those of Lactobacilli and Bifidobacteria and their metabolites in OLP pathogenesis and malignant transformation, focusing on the most recent in vitro and in vivo research evidence. Findings related to their activity in other immune-mediated diseases are here included, suggesting a probiotic translational use in OLP. Probiotics show immune-modulatory and microbiota-balancing activities; they protect the host from pathogens, hamper an excessive effector T cell response, reduce nuclear factor-kappa B (NF-kB) signalling and basal keratinocytes abnormal apoptosis, shifting the mucosal response towards the production of anti-inflammatory cytokines, thus preventing uncontrolled damage. Therefore, probiotics could be a highly encouraging prevention and immunotherapeutic approach for a safer and more sustainable OLP management.

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Section: Probiotic Effects On Cytokine/mmp-mediated Signalling Pathwaysmentioning

confidence: 99%

Probiotics as Potential Biological Immunomodulators in the Management of Oral Lichen Planus: What’s New?

Zanetta

Ormelli

Amoruso

et al. 2022

IJMS

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Lacticaseibacillus caseiCNRZ1874 supplementation promotes M1 alveolar macrophage activation and attenuatesMycoplasma pneumoniaepneumonia

Zhang

Zeng

et al. 2023

Journal of Applied Microbiology

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Aims To evaluate the protective effect of intestinal supplementation with Lacticaseibacillus casei CNRZ1874 on the inflammatory response induced by Mycoplasma pneumoniae in C57BL/6J mice, and provide a potential strategy for alleviating M.pneumoniae pneumonia. Methods and results C57BL/6J mice were gavaged with L. casei CNRZ1874 or PBS for 7 consecutive days, and then infected with M.pneumoniae on day 8. Treatment with L. casei CNRZ1874 significantly reduced M.pneumoniae loads in the lungs and alleviated the lung inflammation on day 3 and day 10 after pathogen infection. Importantly, oral administration with L. casei CNRZ1874 promoted M1 alveolar macrophages activation as evidenced by increased expression of iNOS, TNF-α and CXCL1, while inhibited M2 alveolar macrophages activation as the expression of Arg1 and Chi3l3 were significantly decreased. In consistent with the M1 alveolar macrophages activation and enhanced mycoplasma clearance, the level of TNF-α was increased while the level of IL-4 was decreased in lung tissue from the L. casei CNRZ1874 group compared with the control group. However, oral administration with L. casei CNRZ1874 may not influence adaptive immunity induced by M.pneumoniae as evaluated by M.pneumoniae specific antibodies and T cells responses in spleen. Conclusions Intestinal supplementation with L. casei CNRZ1874 can promote M1 alveolar macrophages activation, which contributes to the clearance of M. pneumoniae and attenuation of M.pneumoniae pneumonia.

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Bacterial Infection Among Covid-19-Infected Patients Admitted to the Intensive Care Unit at King Abdullah Hospital in Bisha: A Single-Centre Retrospective Observational Study

Alharbi,

Nooraldeen,

Mobarki

et al. 2024

ijsmr

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Background: The covid-19 pandemic has created significant challenges for healthcare systems worldwide, especially in intensive care units (ICU), which face unprecedented hardship. Despite the primary focus on viral infection, the precise influence of bacterial superinfections on the outcome of severe covid-19 cases, particularly in different hospital settings, remains uncertain. Objective: to investigate the prevalence, characteristics, and outcomes of bacterial superinfections in covid-19 patients hospitalized in the ICU in Saudi Arabia during the second wave of the pandemic. Methods: This study was conducted at King Abdullah Hospital in Bisha, Saudi Arabia, and involved retrospective observational analysis. This study examined 121 adult patients admitted to the ICU due to severe covid-19 between April and July 2021. Information regarding demographics, clinical characteristics, radiological findings, and microbiological data was also collected. This study examined the relationship between superinfections and mortality through rigorous statistical analyses, including chi-square testing and multivariable logistic regression. Results: Most participants in the study were men (57.9%) and Saudi citizens (95.0%), with an average age of 63 ± 17 years. The incidence of superinfections among the patients was 43.8%, significantly higher than that reported in previous studies. Microbiological examinations revealed the presence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) organisms, particularly in respiratory samples. The most common isolates were KLEPNE-XDR (10.7%) and ACIBAU-XDR (8.3%). A statistically significant correlation was observed between superinfection and mortality (p=0.042). Patients with superinfections experienced a significantly higher mortality rate of 55.3% in comparison to those without superinfections, who had a mortality rate of 44.7%. Multivariable logistic regression identified age (aOR 1.040, 95% CI: 1.012-1.068, p=0.004) and non-Saudi nationality (aOR 12.320, 95% CI: 1.242-122.177, p=0.032) as significant predictors of mortality. Interestingly, a high percentage of the patients (89.3 %) were treated with carbapenems. Conclusion: Our research revealed a notable prevalence of bacterial superinfections, including highly resistant strains, among severely ill covid-19 patients in the ICU. The significant link between superinfections and mortality underscores the pressing need for enhanced diagnostic tools, targeted antimicrobial therapies, and improved stewardship protocols in the ICU setting. The findings of this study have important implications for clinical care and public health policy in the ongoing battle against covid-19 and its consequences.

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Analysis of inflammasomes and CYP27B1 genes in cuprizone demyelinated C57BL/6 mice and evaluation of Th1 and Th2 patterns after oral administration of Lactobacillus casei strain T2 (IBRC-M10783)

Cited by 3 publications

References 45 publications

Probiotics as Potential Biological Immunomodulators in the Management of Oral Lichen Planus: What’s New?

Probiotics as Potential Biological Immunomodulators in the Management of Oral Lichen Planus: What’s New?

Lacticaseibacillus caseiCNRZ1874 supplementation promotes M1 alveolar macrophage activation and attenuatesMycoplasma pneumoniaepneumonia

Bacterial Infection Among Covid-19-Infected Patients Admitted to the Intensive Care Unit at King Abdullah Hospital in Bisha: A Single-Centre Retrospective Observational Study

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