2013
DOI: 10.1155/2013/976810
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Analysis of Inflammatory Mediators in Type 2 Diabetes Patients

Abstract: The main aim of this study is to assess the inflammatory markers in type 2 diabetes mellitus (T2DM) by measuring some cytokines concentrations and lymphocytes subset and correlate them with other laboratory investigations. Fifty-seven patients with type-2 diabetes and 30 healthy volunteers were enrolled in this study. Data for the C-reactive protein (CRP), haemoglobin, HbA1c, and autoantibody levels were obtained from the patients files. The cytokine concentrations were measured in patient's serum using commer… Show more

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Cited by 107 publications
(70 citation statements)
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“…Other studies have reported elevated circulating IL-15 levels after a single bout of resistance or endurance exercise and after 8 weeks of resistance training [38][39][40]. Lower levels of IL-15 have been reported in type 2 diabetic patients compared with controls [41]. Moreover, a negative association has been found in humans between plasma IL-15 levels and total adipose tissue mass [6], and IL-15 has been found to be decreased in obese individuals compared with lean controls [42].…”
Section: Myokines and Metabolic Regulationmentioning
confidence: 99%
“…Other studies have reported elevated circulating IL-15 levels after a single bout of resistance or endurance exercise and after 8 weeks of resistance training [38][39][40]. Lower levels of IL-15 have been reported in type 2 diabetic patients compared with controls [41]. Moreover, a negative association has been found in humans between plasma IL-15 levels and total adipose tissue mass [6], and IL-15 has been found to be decreased in obese individuals compared with lean controls [42].…”
Section: Myokines and Metabolic Regulationmentioning
confidence: 99%
“…Previous studies have demonstrated abnormally high levels of proinfl ammatory cytokines such as IL-1β, IL-6, and CRP in T2DM (6). These cytokines may induce a natural immune response in T2DM patients and strengthen infl ammatory mechanisms in peripheral tissues as well as pancreatic islet cells.…”
Section: Introductionmentioning
confidence: 97%
“…Several studies have found abnormally high circulating levels of proinflammatory cytokines, such as IL-1β, IL-6, and CRP, which may induce the activation of the innate immune system in type 2 diabetic patients and potentiate the inflammatory mechanisms in pancreatic islets as well as in peripheral tissues [6]. On the one hand, hyperglycemia and/or elevated free fatty acid levels induce the production and secretion of various proinflammatory mediators, such as IL-1β, TNF-a, IL-6, and IL-1 dependent cytokines in pancreatic islets [4,7].…”
mentioning
confidence: 99%