Analysis of influencing factors on the method for determining boron concentration and dose through dual prompt gamma detection

Tian, Feng; Geng, Changran; Tang, Xiaobin; Shu, Diyun; Ye, Huangfeng; Bortolussi, Silva; Gong, Chunhui

doi:10.1007/s41365-021-00873-3

Cited by 10 publications

(11 citation statements)

References 36 publications

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“…In addition to DNA, macromolecules can also be damaged, resulting in modulation of their functions [ 38 ]. When these particles pass through a cell, their path is short (α < 10 µm and 7 Li < 5 µm) [ 39 ], so their kinetic energy is released within the target cell, whose diameter is usually ~10 µm. Therefore, it does not affect the surrounding healthy cells.…”

Section: Fundamental Aspects Of Bnctmentioning

confidence: 99%

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Skwierawska

López-Valverde

Balcerzyk

et al. 2022

Cancers

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Boron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron (10B), which makes it a precision medicine treatment modality that provides a therapeutic effect exclusively on patient-specific tumor spread. Contrary to what is usual in radiotherapy, BNCT proposes cell-tailored treatment planning rather than to the tumor mass. The success of BNCT depends mainly on the sufficient spatial biodistribution of 10B located around or within neoplastic cells to produce a high-dose gradient between the tumor and healthy tissue. However, it is not yet possible to precisely determine the concentration of 10B in a specific tissue in real-time using non-invasive methods. Critical issues remain to be resolved if BNCT is to become a valuable, minimally invasive, and efficient treatment. In addition, functional imaging technologies, such as PET, can be applied to determine biological information that can be used for the combined-modality radiotherapy protocol for each specific patient. Regardless, not only imaging methods but also proteomics and gene expression methods will facilitate BNCT becoming a modality of personalized medicine. This work provides an overview of the fundamental principles, recent advances, and future directions of BNCT as cell-targeted cancer therapy for personalized radiation treatment.

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Section: Fundamental Aspects Of Bnctmentioning

confidence: 99%

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Skwierawska

López-Valverde

Balcerzyk

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…All of this happens when a heavy particle passes through the cell nucleus. The reaction products have a concise range (α < 10μm and 7 Li < 5μm) [40], so kinetic energy is delivered to the target cell, whose diameter is usually ~10 μm. Therefore, it does not affect surrounding healthy cells.…”

Section: Mechanisms Of Cell Deathmentioning

confidence: 99%

“…Many different devices like detectors (semiconductor detectors: CZT [83,84], CdTe [85,86]; scintillator detectors [87], and others) have been proposed in the course of numerous researches to promote the clinical translation of this method. Feng et al [40] proposed a dual prompt gamma detection method that could enable an accurate three-dimensional determination and reconstruction of boron concentration in vivo and dose distribution in the region of interest (ROI) during BNCT. This method is based on the relationship between 10 B(n,α) 7 Li and 1 H(n,γ) 2 H reactions.…”

Section: Single-photon Emission Computed Tomography and Prompt Gamma Photons Detectorsmentioning

confidence: 99%

Physical bases of Boron Neutron Capture Therapy, Dosimetry, and Its Mechanisms of Action - Critical Overview of the Literature

Skwierawska¹,

Balcerzyk²,

López-Valverde³

et al. 2021

Preprint

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The success of boron neutron capture therapy(BNCT) mainly depends on sufficient spatial bio-distribution of boron(10B) localized around or within the neoplastic cells to produce a high dose gradient between the tumor and healthy tissue. Contrary to what is usual in radiotherapy, BNCT proposes treatment planning directed at the cell instead of the tumor mass. However, it is not yet possible to precisely determine the concentration of 10B in a specific tissue in real-time using non-invasive methods. Some critical issues still need to be resolved if BNCT is to become valuable, minimally invasive, and efficient cancer treatment. This review article provides an overview of fundamental principles, the recent advances, and future directions of BNCT as cellular targeted cancer therapy. The main emphasis is on topics related to biological dosimetry, methods for as-sessment of boron concentration, mechanisms of action of BNCT, and its physical bases for clinical implementation.

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“…All of this happens when a heavy particle passes through the cell nucleus. The reaction products have a concise range (α < 10µm and 7 Li < 5µm) [33], so the kinetic energy is delivered to the target cell, whose diameter is usually ~10 µm. Therefore, it does not affect the surrounding healthy cells.…”

Section: Mechanisms Of Cell Deathmentioning

confidence: 99%

“…Many different devices like detectors (semiconductor detectors: CZT [72,73], CdTe [74,75]; scintillator detectors [87], and others) have been proposed in the course of numerous researches to promote the clinical translation of this method. Feng et al [33] proposed a dual prompt gamma detection method that could allow an accurate three-dimensional determination and reconstruction of the boron concentration in vivo and the dose distribution in the region of interest (ROI) during BNCT. This method is based on the relationship between 10 B(n,α) 7 Li and 1 H(n,γ) 2 H reactions.…”

Section: Single-photon Emission Computed Tomography and Prompt Gamma Photon Detectorsmentioning

confidence: 99%

Physical Bases of Boron Neutron Capture Therapy, Dosimetry, and Its Mechanisms of Action—A Critical Overview of the Literature

Skwierawska¹,

Balcerzyk²,

López-Valverde³

et al. 2021

Preprint

View full text Add to dashboard Cite

The success of boron neutron capture therapy (BNCT) depends mainly on sufficient spatial biodistribution of boron (B-10) localized around or within neoplastic cells to produce a high dose gradient between the tumor and healthy tissue. Contrary to what is usual in radiotherapy, BNCT proposes treatment planning directed at the cell rather than the tumor mass. However, it is not yet possible to precisely determine the concentration of B-10 in a specific tissue in real-time using non-invasive methods. Some critical issues still need to be resolved if BNCT is to become a valuable, minimally invasive, and efficient cancer treatment. This review article provides an overview of the funda-mental principles, recent advances, and future directions of BNCT as a cell-targeted cancer therapy. The main emphasis is on topics related to biological dosimetry, methods for assessing boron concentration, mechanisms of action of BNCT, and its physical bases for clinical implementation.

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Analysis of influencing factors on the method for determining boron concentration and dose through dual prompt gamma detection

Cited by 10 publications

References 36 publications

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Physical bases of Boron Neutron Capture Therapy, Dosimetry, and Its Mechanisms of Action - Critical Overview of the Literature

Physical Bases of Boron Neutron Capture Therapy, Dosimetry, and Its Mechanisms of Action—A Critical Overview of the Literature

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