Analysis of intra and extramyocellular lipids in the multifidus muscle in patients with chronic low back pain using MR spectroscopy

Takashima, Hiroyuki; Takebayashi, Toru; Ogon, Izaya; Yoshimoto, Mitsunori; Morita, Tomohiro; Imamura, Rui; Nakanishi, Mitsuhiro; Nagahama, Hiroshi; Terashima, Yoshiaki; Yamashita, Toshihiko

doi:10.1259/bjr.20170536

Cited by 22 publications

(25 citation statements)

References 34 publications

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“…MRS analysis of muscle physiology has facilitated detailed analyses of muscular fat masses by recording the concentration of extramyocellular lipids (EMCLs) and intramyocellular lipids (IMCLs), which in turn are useful for the identification of fatty degeneration [24][25][26][27][28][29][30] . In our previous study, IMCL using MRS analyses in the Mm of chronic LBP (CLBP) patients was significantly higher than that in control subjects [31][32][33] . In addition, we identified the associations of spino-pelvic alignment (lumbar lordosis and sagittal vertical axis) with the IMCL of the Mm in CLBP 32) .…”

Section: Introductionmentioning

confidence: 85%

“…We used the previously described MRI protocol [31][32][33] . In brief, the Signa HDx 1.5T MRI system (GE Healthcare, Milwaukee, WI, USA) with a spine coil was used to obtain the T2-weighted sagittal and transverse MR images.…”

Section: Mri Protocolmentioning

confidence: 99%

“…Analysis of MRS data was performed by a method previously described [31][32][33] . The spectral data obtained were used to measure IMCL and EMCL using the LCModel software (Stephen Provencher, Inc., Oakville, Ontario, Canada).…”

Section: Analysis Of Mrs Datamentioning

confidence: 99%

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Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain

Ogon

Takebayashi

Takashima

et al. 2019

Spine Surg Relat Res

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Introduction: Magnetic resonance spectroscopy (MRS) enables detailed analysis of the composition of muscular fat tissues such as intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs). The aim of this study was to analyze the EMCL and IMCL of the multifidus muscle (Mm) using MRS in chronic low-back pain (CLBP) patients and identify their possible correlations with age, body mass index (BMI), low-back pain (LBP) visual analog scale (VAS) score, crosssectional area (CSA), and fat infiltration of the Mm. Methods: Eighty patients (32 men and 48 women; mean age, 64.7 ± 1.3 years; range, 22-83 years) with VAS scores >30 mm for CLBP were included. We analyzed the gender difference and the possible correlations of age, BMI, LBP VAS, CSA, and fat infiltration of the Mm with the IMCL and EMCL of the Mm. The subjects were divided into five groups as per their age range: < 40s, 50s, 60s, 70s, and 80s. We also analyzed the EMCL and IMCL of the Mm as per the fat infiltration classification. Results: CSA was larger in the male group, EMCL was higher in the female group, and there was no significant difference in IMCL between the female and male groups. There was a significant positive correlation of EMCL with age (r = 0.33, p < 0.01) and BMI (r = 0.42, p < 0.01) and a significant negative correlation of EMCL with CSA (r = −0.61, p < 0.01). There was a significant positive correlation between IMCL and VAS (r = 0.43, p < 0.01). The EMCL and CSA of the Mm decreased with age, whereas fat infiltration increased with age. Conclusions: These results suggest that EMCL could indicate Mm degeneration associated with aging, and IMCL could be an effective objective indicator of CLBP. The EMCL and IMCL of the Mm may be useful prognostic markers in rehabilitation strategies.

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Section: Introductionmentioning

confidence: 85%

Section: Mri Protocolmentioning

confidence: 99%

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Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain

Ogon

Takebayashi

Takashima

et al. 2019

Spine Surg Relat Res

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“…This study followed a previously described MRI protocol [20][21][22][23][24]. Briefly, T2-weighted sagittal and transverse magnetic resonance (MR) images were obtained using the Signa HDx 1.5 T MRI system (GE Healthcare, Milwaukee, WI, USA) with a spine coil.…”

Section: Magnetic Resonance Imaging Protocolmentioning

confidence: 99%

“…MRS data were analyzed according to a previously described method [20][21][22][23][24]. Spectral data were used to measure EMCL and IMCL contents using the LCModel software (Stephen Provencher Inc., Oakville, ON, Canada).…”

Section: Analysis Of Magnetic Resonance Spectroscopy Datamentioning

confidence: 99%

Is the Lipid Content of the Psoas Major Correlated with Chronic Low Back Pain and Spinopelvic Alignment? A Magnetic Resonance Spectroscopic Study

et al. 2020

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Study Design: Cross-sectional observational study.Purpose: This study aimed to analyze any potential associations of extramyocellular lipid (EMCL) and intramyocellular lipid (IMCL) contents with (1) the intensity of low back pain (LBP); (2) age, cross-sectional area (CSA), and fatty infiltration (FI) of the psoas major; and (3) spinopelvic parameters.Overview of Literature: The psoas major has clinically relevant function; however, the association of this muscle with chronic LBP is controversial. Magnetic resonance spectroscopy enables a detailed analysis of the composition of muscular fat tissues such as its EMCL and IMCL contents.Methods: The study population comprised 40 patients (19 males, 21 females; mean age, 61.7±2.4 years). Possible correlations of LBP Visual Analog Scale (VAS) scores, age, CSA, FI, and spinopelvic parameters with EMCL and IMCL contents of the psoas major were assessed.Results: No association was identified between the EMCL and IMCL contents and LBP VAS scores (r=0.05, p=0.79 and r=0.06, p=0.75, respectively). The EMCL content correlated with age (r=0.47, p<0.01), body mass index (BMI) (r=0.44, p<0.01), CSA (r=−0.59, p< 0.01), and FI (r=0.49, p<0.01). EMCL content showed a significant negative correlation with sacral slope (SS) (r=−0.43, p<0.05) and positive correlation with pelvic tilt (PT) (r=0.56, p<0.01).Conclusions: EMCL content correlated with age, BMI, CSA, and FI of the psoas major, while IMCL content had no correlation. This study found correlations between SS and PT and EMCL content of the psoas major, but no correlations were found between spinopelvic parameters and IMCL content of the psoas major.

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Medical Strengthening Therapy for Treatment of Back Pain

Spang,

Domokos,

Alfen

2023

Manual of Spine Surgery

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Analysis of intra and extramyocellular lipids in the multifidus muscle in patients with chronic low back pain using MR spectroscopy

Cited by 22 publications

References 34 publications

Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain

Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain

Is the Lipid Content of the Psoas Major Correlated with Chronic Low Back Pain and Spinopelvic Alignment? A Magnetic Resonance Spectroscopic Study

Medical Strengthening Therapy for Treatment of Back Pain

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