Analysis of Ion-Association Reaction in Aqueous Solution and Its Utilization by Capillary Zone Electrophoresis

Takayanagi, Toshio

doi:10.2116/analsci.20.255

Cited by 25 publications

(19 citation statements)

References 110 publications

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“…The advantages of using CZE for the binding analysis include the CZE is done in an pseudo-homogeneous solution without any binary phases; some changes in charge-mass ratio necessarily occur by the binding reaction to give the electrophoretic mobility change even though a spectrum change may not occur due to the binding reaction; and coexisting substances or impurities are allowed to exist by means of the electrophoretic separation. 21 The binding constants for the N-alkylpyridinium ions determined in this study are found to be small compared to the those series for nitrophenolate ions and aromatic sulfonate ions.…”

Section: Introductionmentioning

confidence: 55%

Weak Binding of N-Alkylpyridinium Ions to Nonionic Surfactant Micelles as Studied by Capillary Zone Electrophoresis

2010

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Section: Introductionmentioning

confidence: 55%

Weak Binding of N-Alkylpyridinium Ions to Nonionic Surfactant Micelles as Studied by Capillary Zone Electrophoresis

2010

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“…In particular, flow separation methods, such as chromatography, 1,2 electrophoresis, [3][4][5][6][7] and field flow fractionation (FFF), [8][9][10] have been extensively used in various fundamental and practical fields, and have facilitated the advancements of modern science. These methods cover separation of almost all classes of materials.…”

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confidence: 99%

Solute Distribution Coupled with Laminar Flow in Wide-Bore Capillaries: What Can Be Separated without Chemical or Physical Fields?

et al. 2005

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A number of researches have been devoted to the developments of novel separation principles and methodology, because material separation is one of the most important fundamentals in scientific and technological disciplines. In particular, flow separation methods, such as chromatography, 1,2 electrophoresis, [3][4][5][6][7] and field flow fractionation (FFF), [8][9][10] have been extensively used in various fundamental and practical fields, and have facilitated the advancements of modern science. These methods cover separation of almost all classes of materials. A number of dissolved molecules, from simple ions to macromolecules, can be separated by chromatography or electrophoresis, FFF and electrophoresis being capable of resolving even particles. The dimensions of solutes to be separated by these methods thus range from 10 -10 m to 10 -5 m. This situation may suggest that separation science and technology have been completely matured. However, studying new separation principles is still important, because they can allow the separation based on material properties that have not been utilized for conventional methods, provide higher performance and more efficient separation than existing means, and facilitate the understanding of materials through separation processes.According to chromatographic theories, the intrinsic separation performance of liquid chromatography is restricted in comparison with that of gas chromatography because of much lower solute diffusion in liquid phases. 11However, a liquid flow obviously provides versatile ways for material separation because liquids have higher density and dissolution power than gases, and thus has made possible application to various types of solutes with wide ranges in molecular weights and sizes. In the usual flow separation methods, appropriate chemical (chromatography) or physical (FFF) separation fields are created, which retain solutes to different extents and separate them. A variety of stationary phases for chromatography 2,[12][13][14] and physical forces for FFF [15][16][17][18][19] have been exploited, and have provided different capabilities and selectivity from those performed by conventional separation. In contrast, a separation method that requires neither chemical interactions nor special external fields should also be useful because of its instrumental simplicity. Hydrodynamic chromatography (HDC) is such a case, which allows separation of particles or macromolecules according to their hydrodynamic sizes just by passing them through a narrow channel. [20][21][22][23][24] Particles with larger diameter for example cannot approach the channel wall, and thus flow through the channel faster than the smaller particles, when the laminar flow profile is maintained therein. Although the applicability of this method was very restricted, recent developments of chip technology have brought about a remarkable progress. 23,24 If a capillary of radius a is used for HDC, the time for the elution of a particle of radius rp is given bywhere t0 is the time required ...

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“…(4); then, the values of μep,DPA and Kass were optimized by a nonlinear least-squares analysis. 16 A GNU-style copyleft program, R (The R Foundation for Statistical Computing, Version 2.15.2), 17,18 was used for the analysis. The Kass values determined with the alkali metal ions are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…The effective electrophoretic mobility of DPA -was calculated in the ordinary manner using the experimental conditions and the migration times of DPA -and EOF. 16 Two or more measurements were made to obtain the mean effective mobility.…”

Section: Procedures For the Cze Measurementmentioning

confidence: 99%

“…In this study, the ion-association equilibrium of DPA -was examined in an aqueous solution through electrophoretic mobility measurements by capillary zone electrophoresis (CZE). 16 The electrophoretic mobility of an analyte, DPA -in this case, decreased due to its ion-association equilibrium with a pairing cation; the degree of the decrease was analyzed to determine the ion association constant of the ion-associate. The ion association constants determined for DPA -in this study were almost comparable among alkali metal ions.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Ion-association Equilibrium of Precipitable Dipicrylaminate Ion in Aqueous Solution by Capillary Zone Electrophoresis

2014

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The ion-association equilibrium of the dipicrylaminate ion (DPA -) was investigated in an aqueous solution with alkali metal ions and with its 18-crown-6 ether complexes as pairing cations by capillary zone electrophoresis (CZE). Although DPA -is precipitable with the pairing cations of K + and Cs + in a homogenous aqueous solution, a low concentration of DPA -below its solubility suppressed the formation of the precipitates, and DPA -was detected as a usual CZE signal. Changes in the electrophoretic mobility of DPA -was analyzed for its ion-association equilibrium. The ion association constants determined were almost comparable among alkali metal ions, while the ion association constants were meaningfully large with a hydrophobic 18-crown-6 ether complex of K + . The CZE separation was also proved to be useful for the equilibrium analysis under precipitating conditions. It was suggested that the precipitable property of DPA -with K + and Cs + could not be attributed to the ion-association process in an aqueous solution, but to the condensation process concerning the intermolecular CH···O bond in the precipitate crystals, as reported.Keywords Dipicrylaminate ion, alkali metal ions, 18-crown-6 ether complexes, ion-association equilibrium, aqueous solution, capillary zone electrophoresis

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Analysis of Ion-Association Reaction in Aqueous Solution and Its Utilization by Capillary Zone Electrophoresis

Cited by 25 publications

References 110 publications

Weak Binding of N-Alkylpyridinium Ions to Nonionic Surfactant Micelles as Studied by Capillary Zone Electrophoresis

Weak Binding of N-Alkylpyridinium Ions to Nonionic Surfactant Micelles as Studied by Capillary Zone Electrophoresis

Solute Distribution Coupled with Laminar Flow in Wide-Bore Capillaries: What Can Be Separated without Chemical or Physical Fields?

Analysis of Ion-association Equilibrium of Precipitable Dipicrylaminate Ion in Aqueous Solution by Capillary Zone Electrophoresis

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