Analysis of Ischemic Stroke MR Images by Means of Brain Atlases of Anatomy and Blood Supply Territories

Nowinski, Wiesław L.; Qian, Guoyu; Nagaraja, Bhanu Prakash Kirgaval; Thirunavuukarasuu, A.; Hu, Qingmao; Ivanov, Nick; Parimal, Annamalai Sapayu; Runge, Val M.; Beauchamp, Norman J.

doi:10.1016/j.acra.2006.05.009

Cited by 56 publications

(63 citation statements)

References 16 publications

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“…As a result, it is difficult to directly compare with their results in our case, since the 3D TT brain atlas contains only the structure labels without the intensity information. The commonly used method for the registration of TT brain atlas to image is the Talairach stereotaxic spatial normalization (TT transformation) [15,16,24], which is decided by the anterior/posterior commissures and a set of cortical landmarks in the image to be registered. Since all images I ij are generated from the same phantom brain, the same landmark from all images I ij should be at the same position; and the registration output should be the same if there are no manual operational errors in plotting the required landmarks.…”

Section: Resultsmentioning

confidence: 99%

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Registration of Brain Atlas to MR Images Using Topology Preserving Front Propagation

Liu

Huang

Nowinski

2008

J Sign Process Syst Sign Image Video Technol

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Registration of brain atlases to MR images is important in both anatomic and functional studies of human brains. Existing intensity-based methods are confronted with the translation of image-similarity functions to desired anatomic correspondences; while feature-based methods are challenged with the automated extraction of required features. In this paper, we propose a non-rigid registration method, in which, a block matching method is first used to calculate boundary displacement of all structures in a brain atlas, and a topology preserving front propagation method is then used to deform the atlas by warping the structures according to their boundary displacements. The novelty of our method is that the registration procedure is automated and anatomically driven while there is no need to extract particular structures. Experiments on the registration of the Talairach-Tournoux brain atlas to phantom brain MR images and real data show that our method is robust to noise and intensity inhomogeneity, more accurate than the commonly used Talairach stereotaxic spatial normalization, and thus promising to open new applications for brain atlases.

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Section: Resultsmentioning

confidence: 99%

“…Registration of human brain atlas to clinical images plays important role in many applications such as computational anatomy [27], brain functional image analysis, computer assisted diagnosis [16], image-guided neurosurgery and model-enhanced neuroradiology [15].…”

Section: Introductionmentioning

confidence: 99%

Registration of Brain Atlas to MR Images Using Topology Preserving Front Propagation

Liu

Huang

Nowinski

2008

J Sign Process Syst Sign Image Video Technol

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“…93,94 Regional variation in blood flow abnormalities and topography is already under investigation with the development of perfusion atlases. 95 Because of the practical constraints of acute stroke image acquisition, maximal use of perfusion data is a key priority. Currently, permeability maps that denote regions of contrast leakage in the blood-brain barrier and flow in the microcirculation with flow heterogeneity maps can be generated from routine perfusion acquisitions (Fig 14).…”

Section: Perfusionmentioning

confidence: 99%

Imaging the future of stroke: I. Ischemia

Liebeskind

2009

Annals of Neurology

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Envisioning the future of stroke appears daunting considering the milestones already achieved in stroke imaging. A historical perspective on the developments in stroke care provides a striking narrative of how imaging has transformed diagnosis, therapy, and prognosis of cerebrovascular disorders. Multimodal imaging techniques such as CT and MRI, incorporating parenchymal depictions, illustration of the vasculature, and perfusion data, can provide a wealth of information regarding ischemic pathophysiology. Key elements of ischemic pathophysiology depicted with imaging include vascular occlusion, compensatory collateral flow, resultant hemodynamic conditions that reflect these sources of blood flow, and the neurovascular injury that ensues. The mantra of "time is brain" has been perpetuated, but this does not provide an entirely accurate reflection of ischemic pathophysiology and imaging insight shows far more than time alone. Maximizing the potential of perfusion imaging will continue to expand the nascent concept that cerebral ischemia may be completely reversible in certain scenarios. Novel modalities provide a fertile ground for discovery of therapeutic targets and the potential to assess effects of promising strategies. Beyond clinical trials, imaging has become a requisite component of the neurological examination enabling tailored stroke therapy with the use of detailed neuroimaging modalities. In this first article on ischemia, the focus is on the most recent imaging advances and exploring aspects of cerebral ischemia where imaging may yield additional therapeutic strategies. A subsequent article will review recent and anticipated imaging advances in hemorrhage. These thematic overviews underscore that imaging will undoubtedly continue to dramatically shape the future of stroke.

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“…To facilitate atlas use in neuroradiology, we developed first the Cerefy Neuroradiology Atlas (CNA) [54] and put it on http://www.cerefy.com for public use. Then, we have developed two applications: neuroimage interpretation [55,56] with the fast Talairach transformation [55] allowing for automatic interpretation of normal brain scans in 5 s and the acute ischemic stroke CAD system [57][58][59][60]. Two more stroke CAD systems are under development.…”

Section: Course Of Research and Developmentmentioning

confidence: 99%

From research to clinical practice: lessons learnt from the Cerefy brain atlases

Nowinski

2007

Int J CARS

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Purpose Experience in development and commercialization of the Cerefy brain atlases is shared and compared with some other neuroimaging resources. Materials and Methods Cerefy includes four groups of atlases such as anatomical, functional, vascular and blood supply territories. This project developed 17 brain atlas products being used worldwide in clinical practice, medical research, and education. These atlases are incorporated in more than 1,000 neurosurgical workstations and distributed on over 4,000 CD-ROMs to individual clinicians and medical schools. These brain atlas products were compared with several academic and market performance indicators. Results Cerefy resulted in 13 patents filed and 3 granted, 44 journal papers, 10 international awards, and revenue from commercial products. Numerous anonymous patients have been benefited directly or indirectly from this work, but the impact on surgical practice is more difficult to assess. Conclusion The experience and the lessons learned in the Cerefy brain atlas development were identified, so this can guide other research groups in their translational efforts from bench to bedside.

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Analysis of Ischemic Stroke MR Images by Means of Brain Atlases of Anatomy and Blood Supply Territories

Cited by 56 publications

References 16 publications

Registration of Brain Atlas to MR Images Using Topology Preserving Front Propagation

Registration of Brain Atlas to MR Images Using Topology Preserving Front Propagation

Imaging the future of stroke: I. Ischemia

From research to clinical practice: lessons learnt from the Cerefy brain atlases

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