Analysis of Lipid Profile, Serum Albumin, and Uric Acid Level as Cardiovascular Risk factors Analysis in Renal Transplant Recipients

Abstract

Successful kidney transplantation has been shown repeatedly to be associated with a reduction in mortality compared with dialysis. Studies suggest that this effect largely may be the result of the reduction in cardiovascular disease (CVD) associated with the improvement in renal function. In a retrospective analysis of the United States Renal Data System data consisting of more than 60,000 adult primary kidney transplant recipients transplanted between 1995 to 2000 and more than 66,000 adult wait-listed. Aim of the study is to analyze the risk factors for cardiovascular disease in the renal transplant recipients. All recipients were ABO compatible and cross-match negative and they are followed up regularly in nephrology transplant OPD. Recipients' demographic factors like Age, Gender, Occupation, and Literacy were noted. Nature of donor, post transplant duration, graft function were noted .Fasting blood samples were drawn to determine serum creatinine, Total cholesterol, Triglycerides, LDL and HDL cholesterol and Plasma Glucose concentrations, Hemoglobin, Serum albumin, Uric acid. Cardiovascular mortality is increased in patients with chronic kidney disease. Mortality from cardiovascular disease is10-20 times higher among individuals treated with dialysis, as compared to general population. The incidence of cardiovascular disease in kidney transplant patients is nearly twice that of the general population. Even young transplant recipients (aged 35-45 years) experienced an almost 10-fold increase in cardiovascular disease-related mortality.