Analysis of long‑term functional results of radical mastoidectomy

Mocanu, Horia; Mocanu, Adela-Ioana; Bonciu, Alexandru; Coadă, Gabriella; Schipor, Mihai-Adrian; Rădulescu, Marian

doi:10.3892/etm.2021.10650

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…Glass ceramics (Ceravital) were used to create bioactive implants, which were bio-compatible and reacted with surrounding soft tissue and adjacent bone allowing for an excellent coupling between the implant and the ossicle (30). these bioactive implants were used, with various results obtained worldwide, even in the former communist bloc, including romania (31). Bio-vitro-ceramic PaW-1 (Fig.…”

Section: History and Evolution Of Ossicular Chain Reconstructionmentioning

confidence: 99%

“…1) is a solid, bio reactive, synthetic biomaterial, comprised of fluorescent hydroxyapatite (HA) and wollastonite microcrystals encompassed into a vitreous mass (glass); the material is obtained by the controlled crystallization of a glass from the silicium-calcium-magnesium-phosphorus system with limited additions of boron trioxide and molecular fluoride. It represents a locally developed product (31).…”

Section: History and Evolution Of Ossicular Chain Reconstructionmentioning

confidence: 99%

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Materials for ossicular chain reconstruction: History and evolution (Review)

Mocanu

Dascălu

et al. 2023

Med Int

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the middle ear represents the anatomic space between the external auditory canal and the inner ear (Cochlea). It is comprised of the tympanic membrane, the ossicular chain [malleus (hammer), incus (anvil) and stapes (stirrup)] with the corresponding muscles and ligaments and the cavity of the middle ear. the main function of the middle ear is to convey vibratory energy (sound pressure) from the air to the cochlear fluids of the internal ear via the ossicular chain. tympanoplasty represents a number of procedures used to re-establish the continuity of sound transmission from the tympanic membrane to the inner ear. Ever since the beginning of otologic surgery, various materials have been tested for ossicular chain reconstruction (oCr). the present review aimed to present, in a chronological sequence, the evolution of knowledge regarding this field of medicine, and to also discuss the advantages and disadvantages of different materials and designs of ossicular prostheses. the constant search for more efficient, easily tolerated and lighter materials has improved the acoustic rehabilitation process and has markedly reduced the rate of functional failure of these small prostheses. Contents 1. Introduction 2. Data collection 3. History and evolution of ossicular chain reconstruction 4. Conclusions and future perspectives

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Section: History and Evolution Of Ossicular Chain Reconstructionmentioning

confidence: 99%

Section: History and Evolution Of Ossicular Chain Reconstructionmentioning

confidence: 99%

Materials for ossicular chain reconstruction: History and evolution (Review)

Mocanu

Dascălu

et al. 2023

Med Int

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“…Understanding the pneumatization and anatomic layout is paramount for successfully draining inflammatory lesions. The distribution of middle-ear mucosa lesions is 10% for lesions localized in the anterior and 90% of posterior lesions to a frontal conventionally drawn geometric plan running through the middle of the tympanic cavity, dividing the axial and coaxial spaces of the ME (by ME we understand the sum of protympanum and the cells around it, tympanic cavity with corresponding cells, aditus and antrum with peri-adital cells, mastoid antrum with peri-antral cells) into two segments, anterior and posterior, to the defined geometric plan [27,28].…”

mentioning

confidence: 99%

“…Understanding the pneumatization and anatomic layout is paramount for suc fully draining inflammatory lesions. The distribution of middle-ear mucosa lesions is for lesions localized in the anterior and 90% of posterior lesions to a frontal conventio drawn geometric plan running through the middle of the tympanic cavity, dividin axial and coaxial spaces of the ME (by ME we understand the sum of protympanum the cells around it, tympanic cavity with corresponding cells, aditus and antrum with adital cells, mastoid antrum with peri-antral cells) into two segments, anterior and p rior, to the defined geometric plan[27,28].A number of methods for measuring the size of mastoid pneumatization have reported: the water-weight method, pressurized transducer method and planim method[24,29,30]. The development of radiology has opened new windows into asse the volume of the mastoid cells and a positive correlation between volume and su area of MACS has been shown[29,31].…”

mentioning

confidence: 99%

Geometric–Statistical Model for Middle-Ear Anatomy and Ventilation

Rădulescu

Mocanu²,

Dascălu

et al. 2022

Applied Sciences

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The ventilation of the middle-ear (ME) is achieved by the mucosa covering the bony cavities of this segment, which we have previously defined as consisting of two distinct epithelial areas, each representing an independent organ with characteristic function: the D-Organ and the F-Organ. The D-Organ corresponds to the epithelium covering the Antrum walls (belonging to the central cavities of the middle-ear) and the walls of mastoid and petrous cavities (peripheral cavities of the ME); it ensures the D-Function, the biophysical process comparable to that of energy-consuming ionic membrane pumps, works against electrical trans-membrane gradients to transfer gas molecules against trans-membrane and trans-cellular pressure gradients. The F-Organ corresponds to the epithelium covering the Protympanum, Tympanic Cavity and Aditus ad Antrum (central cavities of ME). The F-Function is represented by the permeability of cell membranes for respiratory gases. This is a general function of all cells and the size of the cellular membrane surface (luminal and basal) and the height of the cell (distance between the two membranes) determines the diffusion flow for each molecular type of gas. The present work aims to give an original point of view on middle-ear geometry and precedence over ME mucosa affliction or structural–anatomic type of the mastoid (pneumatic, pneumato-diploic, diploic, sclerotic). This type of approach to the problem has never been attempted since the two organs have never been previously defined. We aim to establish a clear topographic structure for these two organs within the reference system represented by the anatomy of ME cavities and to establish the reasons why the mastoid and petrous cavitary system grow or stop growing at a certain point in the life of an individual.

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Rare Gene Mutations in Romanian Hypoacusis Patients: Case Series and a Review of the Literature

et al. 2022

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(1) Background: In this paper, we report on three cases of hypoacusis as part of a complex phenotype and some rare gene variants. An extensive review of literature completes the newly reported clinical and genetic information. (2) Methods: The cases range from 2- to 11-year-old boys, all with a complex clinical picture and hearing impairment. In all cases, whole exome sequencing (WES) was performed, in the first case in association with mitochondrial DNA study. (3) Results: The detected variants were: two heterozygous variants in the TWNK gene, one likely pathogenic and another of uncertain clinical significance (autosomal recessive mitochondrial DNA depletion syndrome type 7—hepatocerebral type); heterozygous variants of uncertain significance PACS2 and SYT2 genes (autosomal dominant early infantile epileptic encephalopathy) and a homozygous variant of uncertain significance in SUCLG1 gene (mitochondrial DNA depletion syndrome 9). Some of these genes have never been previously reported as associated with hearing problems. (4) Conclusions: Our cases bring new insights into some rare genetic syndromes. Although the role of TWNK gene in hearing impairment is clear and accordingly reflected in published literature as well as in the present article, for the presented gene variants, a correlation to hearing problems could not yet be established and requires more scientific data. We consider that further studies are necessary for a better understanding of the role of these variants.

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Analysis of long‑term functional results of radical mastoidectomy

Cited by 4 publications

References 24 publications

Materials for ossicular chain reconstruction: History and evolution (Review)

Materials for ossicular chain reconstruction: History and evolution (Review)

Geometric–Statistical Model for Middle-Ear Anatomy and Ventilation

Rare Gene Mutations in Romanian Hypoacusis Patients: Case Series and a Review of the Literature

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