Analysis of long-term results of pathogenetic treatment of Helicobacter pylori-associated gastroduodenopathies induced by nonsteroidal anti-inflammatory drugs in patients with osteoarthritis

Abstract

The study of the pathogenetic treatment and prevention of Helicobacter pylori (Hp)-associated gastroduodenopathies (GDP) induced by nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteoarthritis (OA) is one of the most serious problems in modern clinical medicine. Sixty patients with OA and concomitant Hp-associated GDP induced by NSAIDs were examined. The levels of epidermal growth factor (EDF), sAPO-1/Fas and tumor necrosis factor-α (TNF-α) were determined. Group I included 30 patients who received triple anti-Helicobacter (AHT) therapy, and group II included 30 patients who received rebamipide. Long-term effects were assessed 6 months and 1 year after treatment. All subjects showed a significant increase in TNF-α (4.7 times), EDF (2.2 times) and a decrease in sAPO-1/Fas (3.6 times) levels compared to healthy individuals. After 1 month of treatment, a significantly more significant decrease in TNF-α and an increase in sAPO-1/Fas and EDF was found in group II. In the long-term treatment, a further decrease in TNF-α and an increase in the content of sAPO-1/Fas levels were observed in all groups. However, these changes were significantly more significant in group I compared to group I. The long-term follow-up showed a declining trend of EDF in all groups. The data obtained indicate the effectiveness of rebamipide in the complex pathogenetic treatment and prevention of Hp-associated GDP induced by NSAIDs in patients with OA.

Miya Improves Osteoarthritis Characteristics via the Gut-Muscle-Joint Axis According to Multi-Omics Analyses

“…Desulfovibrio is an endotoxin-producing bacterium ( Li et al, 2021 ) with an increased abundance in patients with symptomatic hand OA ( Wei et al, 2021 ). Shigella , Helicobacter , and Streptococcus are harmful bacteria, and increases in their abundance can lead to increased pain in the knee joint ( Boer et al, 2019 ; Honcharuk et al, 2021 ). Lactobacillus , a type of probiotic, has been reported to alleviate pain and reduce cartilage degradation in OA rats by inhibiting proinflammatory cytokines ( Lee et al, 2018 ).…”

Epithelial protective therapy in comorbid diseases. Practical Guidelines for Physicians

“…Ребамипид не обладает собственным прямым антихеликобактерным действием, однако в экспериментальных работах показано, что он ингибирует адгезию H. pylori к эпителиальным клеткам СО желудка, а также снижает активацию NF-kB и продукцию ИЛ-8, индуцированную микроорганизмом [104].…”