Analysis of low molecular mass organic acids in natural waters by ion exclusion chromatography tandem mass spectrometry

Bylund, Dan; Norström, Sara H.; Essén, Sofia; Lundström, Ulla

doi:10.1016/j.chroma.2007.10.064

Cited by 89 publications

(40 citation statements)

References 19 publications

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“…25,26 The study utilized ion exclusion column chromatography using 0.1% formic acid as the eluent and negative mode detection with electrospray ionization (ESI) mass spectrometry to ensure we achieved optimal performance during the quantification.…”

Section: Succinate Quantitation Using Hplc/msmentioning

confidence: 99%

Succinate Increases in the Vitreous Fluid of Patients With Active Proliferative Diabetic Retinopathy

Matsumoto

Suzuma

Maki

et al. 2012

American Journal of Ophthalmology

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Section: Succinate Quantitation Using Hplc/msmentioning

confidence: 99%

Succinate Increases in the Vitreous Fluid of Patients With Active Proliferative Diabetic Retinopathy

Matsumoto

Suzuma

Maki

et al. 2012

American Journal of Ophthalmology

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“…Samples for analysis of LMMOAs were stored frozen and then determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS; Bylund et al 2007). The LC-MS/MS system was comprised of a Shimadzu LC-10AD pump, an Agilent 1100 autoinjector, a Supelcogel C610-H column (300 9 7.8 mm) and an API3000 mass spectrometer (MDS Sciex, Concord, Canada).…”

Section: Chemical Analysesmentioning

confidence: 99%

Influences of dissolved organic carbon on stream water chemistry in two forested catchments in central Sweden

et al. 2010

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Stream water chemistry in two headwater streams draining two small, adjacent catchments in Bispgården, central Sweden was studied during the 2003 and 2004 growing seasons. The two catchments closely resemble each other in regard to size, shape and drainage density, with the major difference found in the area of wetland lining the streambeds. The emphasis of the study was to investigate the stream water chemistry of these closely resembling catchments, regarding the quality and quantity of dissolved organic carbon (DOC) and its influence on the concentrations of di-and trivalent cations. The streams showed significant differences in the content and size distribution of DOC and in the distribution of cations between the different size fractions. For both streams the high flow events induced by precipitation influenced the chemistry of the streams through increase of organic matter and its associated cations. Fanbergsbäcken, with relatively low pH and high DOC concentration, had a greater amount of high molecular mass (HMM) DOC to which approximately 75% of Al and Fe and about 50% of Ca and Mg were associated. Gråbergsbäcken, with a higher pH and lower DOC level, had approximately 65% of Al, 40% of Fe and 30% of Ca and Mg associated to its HMM DOC fraction. Sixteen different low molecular mass organic acids were found in the stream water, of which oxalic and lactic acid were present in the highest concentrations.

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“…The non-nitrogenous low molecular weight organic acids (LMWOAs) are widely distributed in the natural environment, including water [22], soil [23] and atmosphere [24], and are also the end products of oxidation of many organic pollutants in drinking water treatment plants (DWTPs) [25,26]. Also, many non-nitrogenous LMWOAs, containing one or more carboxyl groups, are characterized by low molecular weight and hydrophilic behavior, and therefore likely to be poorly removed by conventional DWTPs using coagulation-sedimentation-filtration [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

The formation of haloacetamides and other disinfection by-products from non-nitrogenous low-molecular weight organic acids during chloramination

Chu

Bond

et al. 2016

Chemical Engineering Journal

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Low-molecular weight organic acids (LMWOAs) are widespread in nature, and many are recalcitrant during conventional drinking water treatment, due to their LMW and hydrophilic character. This study assessed the formation of a range of disinfection by-products (DBPs) from the chloramination of seven non-nitrogenous LMWOA precursors, with an emphasis on the contribution of N-chloramine incorporation to haloacetamide (HAcAm) formation. The other DBPs comprised chlorinated halomethanes, haloacetonitriles and haloacetic acids. Citric acid generated higher yields of trichloromethane and two chloroacetic acids than the other LMWOAs. Further, the unsaturated acids (fumaric acid and itaconic acid) formed more chloroacetic acids than saturated acids (oxalic acid, succinic acid, adipic acid). Importantly, non-nitrogenous LMWOAs formed three nitrogenous DBPs (dichloroacetamide, trichloroacetamide, and small amounts of dichloroacetonitrile) during chloramination, firstly indicating the monochloramine can supply the nitrogen in nitrogenous DBPs, and the formation of haloacetamides at least in part is independent of the hydrolysis of haloacetonitriles. To the authors' knowledge, this is the first time formation of halogenated nitrogenous DBPs (N-DBPs) has been reported from chloramination of non-nitrogenous LMWOA precursors. This indicates that concentrations of dissolved organic nitrogen compounds in drinking water are not a reliable surrogate for formation of N-DBPs during chloramination. Bromine incorporation factor increased with increasing bromide during chloramination of citric acid, and bromine was easier to incorporate into di-HAcAms than mono-and tri-HAcAms during chloramination.

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Analysis of low molecular mass organic acids in natural waters by ion exclusion chromatography tandem mass spectrometry

Cited by 89 publications

References 19 publications

Succinate Increases in the Vitreous Fluid of Patients With Active Proliferative Diabetic Retinopathy

Succinate Increases in the Vitreous Fluid of Patients With Active Proliferative Diabetic Retinopathy

Influences of dissolved organic carbon on stream water chemistry in two forested catchments in central Sweden

The formation of haloacetamides and other disinfection by-products from non-nitrogenous low-molecular weight organic acids during chloramination

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