Analysis of macrophage migration inhibitory factor (MIF) in patients with idiopathic pulmonary fibrosis

Bargagli, Elena; Olivieri, Carmela; Nikiforakis, Nikolaos; Cintorino, Marcella; Magi, Barbara; Perari, M. G.; Vagaggini, Cecilia; Spina, Domenico; Prasse, Antje; Rottoli, Paola

doi:10.1016/j.resp.2009.05.004

Cited by 44 publications

(40 citation statements)

References 42 publications

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“…[6,7] MIF is a multifunction cytokine produced by macrophages, neutrophils and eosinophils, cellular populations and in our previous manuscripts, MIF concentrations were evaluated by proteomic approach and we reported significantly increased levels in BAL from IPF patients compared with patients suffering from sarcoidosis and pulmonary fibrosis associated with systemic sclerosis. [7,8] A statistically significant increase was found in BAL of IPF patients compared with controls, using a quantitative assay to validate the result. MIF expression from lung tissue was also studied by immunohistochemistry in order to understand the potential involvement of this cytokine in the pathogenesis of idiopathic pulmonary fibrosis.…”

Section: Introductionmentioning

confidence: 88%

Macrophage migration inhibitory factor in lung tissue of idiopathic pulmonary fibrosis patients

Olivieri

Bargagli

Inghilleri

et al. 2016

Experimental Lung Research

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Section: Introductionmentioning

confidence: 88%

Macrophage migration inhibitory factor in lung tissue of idiopathic pulmonary fibrosis patients

Olivieri

Bargagli

Inghilleri

et al. 2016

Experimental Lung Research

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“…Lung fibrosis is associated with numerous hallmarks of aging including telomere shortening, oxidative stress, and aberrant extracellular matrix deposition (73). MIF is increased in the BAL of patients with idiopathic pulmonary fibrosis (IPF) (10,83). Immunohistochemical analysis of lung tissue of patients with IPF demonstrated increased MIF in the epithelium and fibroblastic foci.…”

Section: Mif In Animal Models and Human Studies Of Age-related Lung Dmentioning

confidence: 99%

Role of macrophage migration inhibitory factor in age-related lung disease

Sauler

Bucala

Lee

2015

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…Increased MIF levels have been measured in both bronchial alveolar lavage (31) and serum (45) in patients with asthma. Raised MIF values has also been observed in acute respiratory distress syndrome (ARDS) (22), obstructive sleep apnea (14), and idiopathic pulmonary fibrosis (2).…”

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confidence: 99%

Macrophage migration inhibitory factor, a role in COPD

Husebø

Bakke

Grønseth

et al. 2016

American Journal of Physiology-Lung Cellular and Molecular Phys

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Macrophage migration inhibitor factor (MIF) is a pluripotent cytokine associated with several different inflammatory conditions, but its role within lung inflammation and chronic obstructive pulmonary disease (COPD) is unclear. This study aimed to examine MIF in both stable COPD and during acute exacerbations (AECOPD). The study included 433 patients with COPD aged 41–76 and 325 individuals from the Bergen COPD cohort study who served as controls. All patients had an FEV1 of <80% predicted, FEV1/FVC ratio of <0.7, and a smoking history >10 pack-years. Serum levels of MIF were compared between the two groups at baseline, and for 149 patients, measurements were also carried out during AECOPD. Linear regression models were fitted with MIF as the outcome variable and adjusted for sex, age, body composition, smoking, and Charlson Comorbidity Score (CCS). Median MIF (interquartile range) in patients with COPD was 20.1 ng/ml (13.5–30.9) compared with 14.9 ng/ml (11.1–21.6) in controls ( P < 0.01). MIF was bivariately associated with sex, body composition, and CCS ( P < 0.05 for all). In the regression analyses, MIF was significantly higher in patients with COPD, coefficient 1.32 ( P < 0.01) and 1.30 ( P < 0.01) unadjusted and adjusted, respectively. In addition, in 149 patients during episodes of AECOPD, MIF was significantly elevated, with a median of 23.2 ng/ml (14.1–42.3) compared with measurements at stable disease of 19.3 ng/ml (12.4–31.3, P < 0.01). Serum levels of MIF were significantly higher in patients with COPD compared with controls. We also identified an additional increase in MIF levels during episodes of AECOPD.

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Analysis of macrophage migration inhibitory factor (MIF) in patients with idiopathic pulmonary fibrosis

Cited by 44 publications

References 42 publications

Macrophage migration inhibitory factor in lung tissue of idiopathic pulmonary fibrosis patients

Macrophage migration inhibitory factor in lung tissue of idiopathic pulmonary fibrosis patients

Role of macrophage migration inhibitory factor in age-related lung disease

Macrophage migration inhibitory factor, a role in COPD

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