Analysis of mexicanolide‐ and phragmalin‐type limonoids from Heynea trijuga using high‐performance liquid chromatography/electrospray tandem mass spectrometry

Abstract

An HPLC/ESI-MS/MS method was developed and could be used to simultaneously identify and screen phragmalin- and mexicanolide-type limonoids in botanic extracts of Heynea trijuga.

Comparative metabolism of four limonoids in human liver microsomes using ultra‐high‐performance liquid chromatography coupled with high‐resolution LTQ‐Orbitrap mass spectrometry

“…The structure of limonin exemplifies the first common nucleus, which consists of five rings. The second consists of four rings designated as A, B, C, and D, such as obacunone, nomilin, gedunin, mexicanolide‐ and phragmalin‐type limonoids . The structural difference in the limonoid nucleus would influence their biological activities.…”

“…At present, limonoids have gained significant importance because of their aforementioned biological activities and the possibility to determine limonoids in rat plasma and human urine . The electron ionization (EI) and atmospheric pressure chemical ionization (APCI) tandem mass spectrometric (MS/MS) fragmentation pathways of limonoid aglycones and ESI‐MS/MS fragmentations of limonoids have been reported . However, few studies about the metabolic profiles of limonoids have been carried out.…”

Species‐related difference between limonin and obacunone among five liver microsomes and zebrafish using ultra‐high‐performance liquid chromatography coupled with a LTQ‐Orbitrap mass spectrometer

“…Based on the accurate mass data, the structures of metabolites can be characterized and identified accurately and quickly. Although the fragments of limonin and obacunone have been reported under electron ionization (EI)‐MS conditions, their fragmentation by electrospray ionization tandem mass spectrometry (ESI‐MS/MS) should be studied comprehensively, because of the large number of determinations using ESI …”

Wood chemotaxonomy via ESI-MS profiles of phytochemical markers: the challenging case of African versus Brazilian mahogany woods

“…4a) was attributed to [M À H] À of the procyanidin dimer, fragments as expected mainly to the ion of m/z 289, e.g. 45 The very unique BM anion of m/z 451 (Fig. The ion of m/z 493 (methyl angolensate), which forms the base ion peak of the AM extract in the ESI(+) spectra (Fig.…”