Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population

Sadki, Khalid; Lamsyah, H.; Rueda, Blanca; Akil, ELmahfoud; Sadak, Abderrahim; Martín, Javier; Aouad, Rajae El

doi:10.1016/s1673-8527(09)60044-8

Cited by 27 publications

(29 citation statements)

References 48 publications

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“…The FcγRIIa R131 allele does not bind human IgG2 (whereas H131 does) and is associated with increased infection and/or disease progression with some encapsulated bacteria and viruses [206–210], while the FcγRIIIa F158 allele has lower affinity for IgG1 and IgG3 antibodies relative to V158, and has been described as a heritable risk factor for some vasculitis diseases [211–213]. Only one study has looked for an association between FcγR polymorphisms and susceptibility to tuberculosis; specifically, the FcγRIIa R131H and FcγRIIIa F158V polymorphisms in active tuberculous patients versus healthy controls in the Moroccan population was investigated [214]. No significant association was found.…”

Section: The Contribution Of Antibodies and B Cells To Shaping The Homentioning

confidence: 99%

The role of B cells and humoral immunity in Mycobacterium tuberculosis infection

Chan

Mehta

Bharrhan

et al. 2014

Seminars in Immunology

137

123

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Mycobacterium tuberculosis remains a major public health burden. It is generally thought that while B cell- and antibody-mediated immunity plays an important role in host defense against extracellular pathogens, the primary control of intracellular microbes derives from cellular immune mechanisms. Studies on the immune regulatory mechanisms during infection with M. tuberculosis, a facultative intracellular organism, has established the importance of cell-mediated immunity in host defense during tuberculous infection. Emerging evidence suggest a role for B cell and humoral immunity in the control of intracellular pathogens, including obligatory species, through interactions with the cell-mediated immune compartment. Recent studies have shown that B cells and antibodies can significantly impact on the development of immune responses to the tubercle bacillus. In this review, we present experimental evidence supporting the notion that the importance of humoral and cellular immunity in host defense may not be entirely determined by the niche of the pathogen. A comprehensive approach that examines both humoral and cellular immunity could lead to better understanding of the immune response to M. tuberculosis.

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Section: The Contribution Of Antibodies and B Cells To Shaping The Homentioning

confidence: 99%

The role of B cells and humoral immunity in Mycobacterium tuberculosis infection

Chan

Mehta

Bharrhan

et al. 2014

Seminars in Immunology

137

123

View full text Add to dashboard Cite

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“…Initial studies of the role of variant MIF alleles in TB have yielded disparate results. Although investigations of the -794 CATT and -173 SNP have suggested associations between the -794 CATT 7,8 alleles and TB in a Chinese Han population, and the -173 C allele and TB in Columbian and Moroccan populations, an investigation of MIF levels in HIV/ TB-coinfected patients in Tanzania found that patients with low circulating MIF levels have higher mortality (35)(36)(37)(38). Notably, MIF genotype investigations have not been undertaken in African HIV/TB-coinfected patients despite the critical role of immune control and the enormity of disease burden in this population.…”

Section: Significancementioning

confidence: 99%

Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis

Das

Koo²,

Kim

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

111

112

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Significance Failure of the host immune system to control infection with Mycobacterium tuberculosis is a major determinant of tuberculosis (TB) disease. In this work, we examined the role of macrophage migration inhibitory factor (MIF), a cytokine that is encoded in a functionally polymorphic locus in humans, in TB. We found genetic low expressers of MIF to be enriched in a population of patients with HIV and disseminated TB. From our work in cellular and mouse models, we propose a key mechanism by which MIF regulates bacterial recognition as the first step in triggering inflammatory pathways to enable mycobacterial control.

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“…FcγR − / - mice are more susceptible to infection with M.tb , and loss of function of the inhibitory FcγRIIb improves TB outcome by enhancing IL-12, granuloma formation and IFN-γ levels [82]. A small pilot study in Ethiopia found the presence of FcγR3b copy-number variations to confer additional risk of developing TB in patients with HIV infection, although similar findings were not evident in another Moroccan cohort [83], [84].…”

Section: Introductionmentioning

confidence: 99%

Antibodies and tuberculosis

et al. 2016

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SummaryTuberculosis (TB) remains a major public health problem internationally, causing 9.6 million new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine is the only licensed vaccine against TB, but its protective effect does not extend to controlling the development of infectious pulmonary disease in adults. The development of a more effective vaccine against TB is therefore a pressing need for global health. Although it is established that cell-mediated immunity is necessary for the control of latent infection, the presupposition that such immunity is sufficient for vaccine-induced protection has recently been challenged. A greater understanding of protective immunity against TB is required to guide future vaccine strategies against TB.In contrast to cell-mediated immunity, the human antibody response against M.tb is conventionally thought to exert little immune control over the course of infection. Humoral responses are prominent during active TB disease, and have even been postulated to contribute to immunopathology. However, there is evidence to suggest that specific antibodies may limit the dissemination of M.tb, and potentially also play a role in prevention of infection via mucosal immunity. Further, antibodies are now understood to confer protection against a range of intracellular pathogens by modulating immunity via Fc-receptor mediated phagocytosis. In this review, we will explore the evidence that antibody-mediated immunity could be reconsidered in the search for new vaccine strategies against TB.

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Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population

Cited by 27 publications

References 48 publications

The role of B cells and humoral immunity in Mycobacterium tuberculosis infection

The role of B cells and humoral immunity in Mycobacterium tuberculosis infection

Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis

Antibodies and tuberculosis

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