2023
DOI: 10.20473/jfiki.v10i32023.347-359
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Analysis of Molecular Docking and Dynamics Simulation of Mahogany (Swietenia macrophylla King) Compounds Against the PLpro Enzyme SARS-COV-2

Lalu Sanik Wahyu Fadil Amrulloh,
Nuraini Harmastuti,
Andri Prasetiyo
et al.

Abstract: Background: Using natural ingredients as antivirals can be considered a treatment for SARS-CoV-2. One of the potential plants, mahogany (Swietenia macrophylla King), is widely used in various countries as an antiviral treatment. Paparin-like protease (PLpro) is an essential cysteine ​​protease that regulates viral replication and interferes with the regulation of immune sensing. Objective: This study aims to predict which compounds in the mahogany plant have good affinity, patterns, and stability interaction a… Show more

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