Analysis of multiclass antibiotic residues in urban wastewater in Tunisia

Harrabi, Malek; Giustina, Saulo Varela Della; Aloulou, Fatma; Rodríguez-Mozaz, Sara; Barceló, Damià; Elleuch, Boubaker

doi:10.1016/j.enmm.2018.05.006

Cited by 51 publications

(29 citation statements)

References 69 publications

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“…This issue is particularly relevant to pharmaceuticals that are mainly excreted In this study, a negative removal rate for azithromycin, clindamycin, lincomycin, and thiabendazole was observed ( Figure 2). Moreover, for these antimicrobials, a high variance in removal rate was noted, which agrees with previous studies in which certain antimicrobials were reported to be more abundant in effluents than influents [6,8,10,25,33,48].…”

Section: Antimicrobials' Removal Efficiencysupporting

confidence: 90%

“…In their studies, the predicted no effect concentration (PNEC) was, however, calculated differently compared to our study. The authors obtained PNEC values 1000 times lower than the toxicity values found for the most sensitive eukaryotic species that were assayed [6,33]. In our study, other factors, i.e.1000, 100, 50 or10, were used to calculate PNEC.…”

Section: Environmental Risk Assessmentmentioning

confidence: 64%

“…Verlicchi et al [33] published a review, which reported that six antimicrobials posed a high environmental risk for eukaryotes, i.e., erythromycin, ofloxacin, sulfamethoxazole, clarithromycin, tetracycline, and azithromycin. Harrabi et al [6] observed a high risk for ofloxacin, ciprofloxacin, azithromycin, sulfamethoxazole, and trimethoprim for eukaryotic species; however, clarithromycin was not evaluated. In their studies, the predicted no effect concentration (PNEC) was, however, calculated differently compared to our study.…”

Section: Environmental Risk Assessmentmentioning

confidence: 99%

“…However, human excretion is considered to be the most important source. Generally, WWTPs are not designed to eliminate PhACs during the technological process, and a number of studies have shown the presence of different PhACs in both raw and treated sewage sludge and wastewater [4][5][6][7][8]. There is no data on either the removal efficiency or the concentration of antimicrobials in Polish WWTPs.…”

Section: Introductionmentioning

confidence: 99%

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Environmental Risk and Risk of Resistance Selection Due to Antimicrobials’ Occurrence in Two Polish Wastewater Treatment Plants and Receiving Surface Water

et al. 2020

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In this study, a screening of 26 selected antimicrobials using liquid chromatography coupled to a tandem mass spectrometry method in two Polish wastewater treatment plants and their receiving surface waters was provided. The highest average concentrations of metronidazole (7400 ng/L), ciprofloxacin (4300 ng/L), vancomycin (3200 ng/L), and sulfamethoxazole (3000 ng/L) were observed in influent of WWTP2. Ciprofloxacin and sulfamethoxazole were the most dominant antimicrobials in influent and effluent of both WWTPs. In the sludge samples the highest mean concentrations were found for ciprofloxacin (up to 28 μg/g) and norfloxacin (up to 5.3 μg/g). The removal efficiency of tested antimicrobials was found to be more than 50% for both WWTPs. However, the presence of antimicrobials influenced their concentrations in the receiving waters. The highest antimicrobial resistance risk was estimated in influent of WWTPs for azithromycin, ciprofloxacin, clarithromycin, metronidazole, and trimethoprim and in the sludge samples for the following antimicrobials: azithromycin, ciprofloxacin, clarithromycin, norfloxacin, trimethoprim, ofloxacin, and tetracycline. The high environmental risk for exposure to azithromycin, clarithromycin, and sulfamethoxazole to both cyanobacteria and eukaryotic species in effluents and/or receiving water was noted. Following the obtained results, we suggest extending the watch list of the Water Framework Directive for Union-wide monitoring with sulfamethoxazole.

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Section: Antimicrobials' Removal Efficiencysupporting

confidence: 90%

Section: Environmental Risk Assessmentmentioning

confidence: 64%

Section: Environmental Risk Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Environmental Risk and Risk of Resistance Selection Due to Antimicrobials’ Occurrence in Two Polish Wastewater Treatment Plants and Receiving Surface Water

et al. 2020

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“…[6][7][8] Currently, there is great concern about multi-resistant bacteria occurring in wastewater treatment plants (WWTPs), since these units were not designed to remove ECs and provide an environment that is favorable for microorganism multiplication. 1,2,6,[9][10][11][12] It is known from the literature 2,13-17 that pharmaceutical compounds may be partially degraded (producing more toxic sub-products) or may remain unchanged during conventional treatment in WWTPs and then be released into water bodies. Within this perspective, ciprooxacin (CIP) has received great attention owing to its multi-resistant bacteria effect.…”

Section: Introductionmentioning

confidence: 99%

Simple, fast and environmentally friendly method to determine ciprofloxacin in wastewater samples based on an impedimetric immunosensor

et al. 2020

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In this study an impedimetric immunosensor was developed in order to determine ciprofloxacin (CIP) in wastewater samples, an emergent contaminant widely found in wastewater. To achieve this, an anticiprofloxacin antibody was immobilized on the surface of a printed carbon electrode. Then, the developed immunosensor was applied in wastewater samples from Université Laval residences (Québec, Canada) through the load transfer resistance (R ct ) using [Fe(CN) 6 ] 3À/4À as a redox probe, and the average CIP concentration was found to be 2.90 Â 10 À4 mg mL À1 . The observed R ct changes presented a linear relationship from CIP concentrations of 10 À5 to 1.0 mg mL À1 , with detection and quantification limits of 2.50 Â 10 À6 and 7.90 Â 10 À6 mg mL À1 , respectively. The immunosensor presented high selectivity and repeatability, as well as a good recovery rate in wastewater samples (97%). Significant interference with other compounds was not observed. The proposed method requires only 30 mL of sample without the use of organic solvents or preceding sample preparation and/or extraction techniques. Moreover, the method is fast: only 20 min of incubation followed by 2 min of analysis time was sufficient to obtain the CIP concentration. The method's estimated cost is U$ 2.00 per sample.

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Physicochemical properties of antibiotics: A review with an emphasis on detection in the aquatic environment

Ozumchelouei

Hamidian

Yang

2019

Water Environment Research

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Antibiotics have extensively been applied to rescue a great number of lives through prevention and treatment of contagious diseases and infections. They are either natural or human-made substances, which are broadly employed for promoting the health condition of human, plant, and animal. However, antibiotics are known to exert detrimental impacts on useful and nontarget microbiota of the biological system due to the overuse, continuous discharge into the environment, and subsequently aggregation in various environmental matrices. Physical and chemical properties help to evaluate whether a substance is more likely to concentrate on the terrestrial, aquatic, or atmospheric environmental matrix as well as its fate. Therefore, appropriate characterization and proper understanding of physicochemical attributes of antibiotics are indispensable to protect ecosystem health. In this paper, the antibiotic classifications and their physicochemical properties were reviewed with emphasis on detection in the aqueous environment. • Practitioner points• Antibiotic compounds were classified in main classes, groups, and their main use. • Tetracyclines, sulfonamides, aminoglycosides, macrolides, β-lactams, quinolones, polyether ionophores, and glycopeptides are the most commonly detected antibiotics in the aquatic environment. • Physical-chemical properties of the main antimicrobial classes were mentioned. • Physicochemical properties can change under different environmental conditions such as pH and temperature.

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Analysis of multiclass antibiotic residues in urban wastewater in Tunisia

Cited by 51 publications

References 69 publications

Environmental Risk and Risk of Resistance Selection Due to Antimicrobials’ Occurrence in Two Polish Wastewater Treatment Plants and Receiving Surface Water

Environmental Risk and Risk of Resistance Selection Due to Antimicrobials’ Occurrence in Two Polish Wastewater Treatment Plants and Receiving Surface Water

Simple, fast and environmentally friendly method to determine ciprofloxacin in wastewater samples based on an impedimetric immunosensor

Physicochemical properties of antibiotics: A review with an emphasis on detection in the aquatic environment

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