Analysis of multiple event related potential components in a tone discrimination task

Lindholm, Ernest; Koriath, John Jay

doi:10.1016/0167-8760(85)90032-7

Cited by 47 publications

(34 citation statements)

References 14 publications

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“…These results suggest that mental training may have also affected processes reflected by the P200. The P200 is typically associated with the beginning of an executive process responsible for stimulus identification and the initiation of decision making, and is also modulated by attention (Lindholm and Koriath, 1985). In line with previous studies, a smaller P200 (averaged between 150–300ms) was observed to attended vs. unattended deviant tones (paired t-test for all participants attended vs. unattended deviant tones averaged across time 1 and time2, p<0.000001, t(1,30)>6.4 above Fz and Cz).…”

Section: Resultsmentioning

confidence: 99%

“…This effect was also highly similar both in time course and scalp topography to the P200 (Figure 3). This ERP component is typically associated with the beginning of executive processes responsible for stimulus identification and the initiation of decision-making and is also modulated by attention (Lindholm and Koriath, 1985). This point is important if one assumes that monitoring of distractors is one important mechanism for regulating task-unrelated thoughts processes during task performance (Lutz et al, 2008a).…”

Section: Discussionmentioning

confidence: 99%

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Mental Training Enhances Attentional Stability: Neural and Behavioral Evidence

Lutz¹,

Slagter²,

Rawlings³

et al. 2009

J. Neurosci.

421

335

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The capacity to stabilize the content of attention over time varies among individuals, and its impairment is a hallmark of several mental illnesses. Impairments in sustained attention in patients with attention disorders have been associated with increased trial-to-trial variability in reaction time and event-related potential deficits during attention tasks. At present, it is unclear whether the ability to sustain attention and its underlying brain circuitry are transformable through training. Here, we show, with dichotic listening task performance and electroencephalography, that training attention, as cultivated by meditation, can improve the ability to sustain attention. Three months of intensive meditation training reduced variability in attentional processing of target tones, as indicated by both enhanced theta-band phase consistency of oscillatory neural responses over anterior brain areas and reduced reaction time variability. Furthermore, those individuals who showed the greatest increase in neural response consistency showed the largest decrease in behavioral response variability. Notably, we also observed reduced variability in neural processing, in particular in low-frequency bands, regardless of whether the deviant tone was attended or unattended. Focused attention meditation may thus affect both distracter and target processing, perhaps by enhancing entrainment of neuronal oscillations to sensory input rhythms, a mechanism important for controlling the content of attention. These novel findings highlight the mechanisms underlying focused attention meditation and support the notion that mental training can significantly affect attention and brain function.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mental Training Enhances Attentional Stability: Neural and Behavioral Evidence

Lutz¹,

Slagter²,

Rawlings³

et al. 2009

J. Neurosci.

421

335

View full text Add to dashboard Cite

show abstract

“…These effects need to be clarified by further investigation. The P2 component is believed to be functionally connected with an automatic stimulus identification and classification (Lindholm and Koriath, 1985). The P2 alterations may reflect an early orienting or preparatory problem which affects later processing stages in the stop-signal task (Brandeis et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Response inhibition of children with ADHD in the stop-signal task: An event-related potential study

Senderecka

Grabowska

Szewczyk

et al. 2012

International Journal of Psychophysiology

120

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“…For statistical analysis, three distinct time windows during which subject-level ERP peaks (point with greatest absolute maxima within a time window) were selected: 1) 100–150 ms is believed to represent early sensory components (Herrmann and Knight, 2001), 2) a middle latency transitional peak (150–250 ms) post stimulus corresponds to response selection (Heslenfeld et al, 1997; Kenemans et al, 1993; Lindholm and Koriath, 1985) and 3) a later temporal window (300–575 ms) post stimulus is considered to represent response action and visual feedback processes (Fallgater et al, 2001). Behaviorally, response inhibition is measured as a false alarm rate for non-target stimuli; its neurophysiological correlate is assessed by quantifying brain electrical field frontalization during correctly identified non-target stimuli (Fallgater et al, 1997; Young et al, 2017).…”

Section: Adaptationsmentioning

confidence: 99%

The 5 choice continuous performance test (5C-CPT): A novel tool to assess cognitive control across species

Bhakta

Young

2017

Journal of Neuroscience Methods

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Background Neurodevelopmental disorders including Tourette’s syndrome (TS) and attention deficit hyperactivity disorder (ADHD) are characterized by significant impairment in attention and cognitive control. These cognitive deficits persist throughout development, contribute significantly to socio-occupational impairment, and are relatively impervious to available treatment. A critical challenge in pro-cognitive drug discovery is translatability of findings across species, underscoring the need for developing valid and reliable cross-species cognitive tasks. New Method Here we describe a cross-species 5 choice continuous performance task that was developed to measure cognitive control processes of attention, vigilance, and response inhibition, enabling the translation of findings for pro-cognitive drug discovery across species and delineate neural mechanisms underlying cognitive control construct. Results Construct validity of 5C-CPT has been verified by multiple cross-species studies. Several lines of evidence report consistent findings across species including, deficits resulting from 36-hour sleep deprivation studies, engagement of parietal cortex in human brain imaging and rodent lesion studies, and vigilance decrements over time. Comparison with existing method Unlike the widely used rodent 5 choice serial reaction time task (5CSRTT) and the sustained attention task (SAT), the rodent 5C-CPT includes both target and non-target stimuli that allow measuring of cognitive control elements including response inhibition, an ability to inhibit pre-potent response during non-target trials, detect vigilance decrement and calculate signal detection parameters in rodents analogous to human CPT. Conclusion The cross-species 5C-CPT is a robust translational tool to characterize the neurobiological substrates underlying cognitive control deficits in clinical population including, ADHD and TS and develop targeted pro-cognitive therapeutics.

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Analysis of multiple event related potential components in a tone discrimination task

Cited by 47 publications

References 14 publications

Mental Training Enhances Attentional Stability: Neural and Behavioral Evidence

Mental Training Enhances Attentional Stability: Neural and Behavioral Evidence

Response inhibition of children with ADHD in the stop-signal task: An event-related potential study

The 5 choice continuous performance test (5C-CPT): A novel tool to assess cognitive control across species

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