Analysis of multiple factors involved in acute progressive cerebral infarction and extra- and intracranial arterial lesions

Abstract

In order to identify the potential factors involved in the development of acute progressive cerebral infarction (PCI), the association between potential risk factors and extra- and intracranial arterial lesions was investigated. A total of 608 patients underwent cerebral angiography to analyze the morphological characteristics between the PCI and NPCI groups. In addition, data from numerous cases of extra- and intracranial arterial lesions were collected and compared with the control groups, and the associations between the severity of arterial lesions and the potential influential factors were analyzed. In the blood vessels responsible for cerebral infarction, various degrees of atherosclerotic plaques and stenosis were observed. Age, high-density lipoprotein (HDL) levels, glycosylated hemoglobin and blood pressure affected the degrees of hardening, plaques and stenosis. Analysis of cerebral artery stenosis revealed that age, diabetes mellitus and plasma fibrinogen were risk factors for cerebral artery stenosis, while the HDL/low density lipoprotein ratio was a protective factor. Therefore, the results of the present study indicate that the lesions of blood vessels are a major pathological change in PCI and multiple factors are involved in the pathogenesis.

Influencing Factors of Early Neurological Deterioration and Short-Term Prognosis after Intravenous Thrombolysis in Patients with Acute Ischemic Stroke

“…In recent years, with the increase in the incidence of AIS, and due to the population bias, which mainly concentrated in the elderly with other underlying diseases, the incidence of END continues to rise, and it tends to cause a poor prognosis for AIS patients, such as disability or even death [ 7 , 8 ]. The mechanism of the occurrence of END in AIS patients is not yet clear, and it is generally believed to be the result of a combination of multiple factors (such as poor medial branch circulation of the lesion, intracranial hypertension, hemorrhagic transformation, reocclusion of blood vessels); thus, it is difficult to prevent and treat END [ 9 ].…”

Effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction

“…Platelet aggregation caused by atherosclerotic plaque rupture and vascular endothelial injury is the vital pathological link of acute cerebral infarction [12][13][14]. The ginkgo-diyidamolum used in the present study has an anti-platelet effect through different ways.…”

Serum C-reactive protein, fibrinogen and D-dimer in patients with progressive cerebral infarction

“…Using transcranial Doppler, Álvarez et al . reported [30] cerebral hemodynamic reserve impairment within the first 24 h of acute ischemic stroke is associated with a higher risk of early neurological deterioration. Impaired cerebral hemodynamic reserve at stroke onset probably indicates that the vasodilator compensatory mechanisms are exhausted and consequently that there is a high risk of recruitment of the oligemic ischemic tissue into infarction.…”