Analysis of Myocardial Infarction Time Course in Women Compared With Men in Upper Silesia Population in 30 Day Follow-Up

Kawecki, Damian; Tomasik, Andrzej; Morawiec, Beata; Jacheć, W; Wojciechowska, Celina; Rybczyk, Renata; Milejski, Wojciech; Switalska-Janiczek, Izabela; Przywara-Chowaniec, Brygida; Nowalany-Kozielska, Ewa

doi:10.1536/ihj.50.711

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…Elderly women who have survived a myocardial infarction frequently visit their doctors complaining of chest pain and have significantly higher mortality rate, target lesion reoclussion (3,24), postinfarction refractory anaemia in the short term, and AMI in the long term (25,26). Although cardiac troponin is a pivotal marker of cardiac ischaemic injury/necrosis (27), a single negative cTnI test is not sufficient to disregard the presence of AMI because of its low sensitivity in the first 3 h of chest pain onset (2,3).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome

et al. 2012

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Introduction: This study aimed to assess whether heart fatty acid-binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) could be used for the accurate diagnosis of acute myocardial infarction (AMI) in acute coronary syndrome (ACS) patients. Materials and methods: The study included 108 ACS patients admitted to a coronary unit within 3 h after chest pain onset. AMI was distinguished from unstable angina (UA) using a classical cardiac troponin I (cTnI) assay. H-FABP and GPBB were measured by ELISA on admission (0 h) and at 3, 6, 12, and 24 h after admission; their accuracy to diagnose AMI was assessed using statistical methods. Results: From 92 patients with ACS; 71 had AMI. H-FABP and GPBB had higher peak value after 3 h from admission than cTnI (P = 0.001). Both markers normalized at 24 h. The area under the receiver operating characteristic curves was signifi cantly greater for both markers in AMI patients than in UA patients at all time points tested, including admission (P < 0.001). At admission, the H-FABP (37%) and GPBB (40%) sensitivities were relatively low. They increased at 3 and 6 h after admission for both markers and decreased again after 24 h. It was 40% for H-FABP and approximately 2-times lower for GPBB (P < 0.01). In AMI patients, both biomarkers had similar specifi cities, positive-and negative-predictive values, positive and negative likelihood ratios, and risk ratios for AIM. Conclusion: H-FABP and GPBB can contribute to early AMI diagnosis and can distinguish AMI from UA.

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Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome

et al. 2012

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“…The incidence of VA during hospitalization for ACS in our study is similar to that reported in previous studies of patients with STEMI and NSTEMI enrolled in randomized clinical trials (RCT). 7 Additionally, RCT patients were more likely to be men 11 – 13 and have a history of coronary heart disease 14 and hyperlipidemia, 15 and have Killip class >I on admission. Our baseline findings revealed less coronary artery disease and hyperlipidemia compared with these published studies.…”

Section: Discussionmentioning

confidence: 99%

Incidence of ventricular arrhythmia and associated patient outcomes in hospitalized acute coronary syndrome patients in Saudi Arabia: findings from the registry of the Saudi Project for Assessment of Acute Coronary Syndrome (SPACE)

Hersi

AlHabib

AlFaleh

et al. 2012

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVESMortality in acute coronary syndrome (ACS) patients with ventricular arrhythmia (VA) has been shown to be higher than those without VA. However, there is a paucity of data on VA among ACS patients in the Middle Eastern countries.DESIGN AND SETTINGProspective study of patients admitted in 17 government hospitals with ACS between December 2005 and December 2007.PATIENTS AND METHODSPatients were categorized as having VA if they experienced either ventricular fibrillation (VF) or sustained ventricular tachycardia (VT) or both.RESULTSOf 5055 patients with ACS enrolled in the SPACE registry, 168 (3.3%) were diagnosed with VA and 151 (98.8%) occurred in-hospital. The vast majority (74.4%) occurred in patients with ST-segment elevation myocardial infarction. In addition, males were twice as likely to develop VA than females (OR 1.7; 95% CI 1.1–3). Killip class >I (OR 2.0; 95% CI 1.3–3.1); and systolic blood pressure <90 mm Hg (OR 6.4; 95% CI 3.5–11.8) were positively associated with VA. Those admitted with hyperlipidemia (OR 0.49; 95% CI 0.3–0.7) had a lower risk of developing VA. Adverse in-hospital outcomes including re-myocardial infarction, cardiogenic shock, congestive heart failure, major bleeding, and stroke were higher for patients with VA (P≤.01 for all variables) and signified a poor prognosis. The in-hospital mortality rate was significantly higher in VA patients compared with non-VA patients (27% vs 2.2%; P=.001).CONCLUSIONSIn-hospital VA in Saudi patients with ACS was associated with remarkably high rates of adverse events and increased in-hospital mortality. Using a well-developed registry data with a large number of patients, our study documented for the first time the prevalence and risk factors of VA in unselected population of ACS.

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“…Many studies have shown that poor clinical outcomes in women are related to suboptimal [26][27][28][29]. Conversely, several lines of evidence indicate that guidelines-compliant treatment in women and men results in significant improvements in outcomes [30]. It is known that a delay in the application of invasive treatment significantly worsens the prognosis of patients with STEMI [31].…”

Section: Bmi -Body Mass Index (Kg/m 2 ) MI -Myocardial Infarction Pmentioning

confidence: 99%

Mortality of women with ST-segment elevation myocardial infarction and cardiogenic shock – results from the PL-ACS registry

Kołodziej¹,

Kurzawski²,

Janion−Sadowska³

et al. 2016

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Słowa kluczowe: wstrząs kardiogenny, strategia rewaskularyzacji, optymalne leczenie, śmiertelność, różnice zależne od płci. AbstractIntroduction: Gender-related differences are well elucidated in ST-segment elevation myocardial infarction (STEMI) patients. However, data on patients with cardiogenic shock (CS) are scarce and do not indicate the cause-effect relationship. Aim of the research: To evaluate the differences between women and men with CS complicating STEMI and to identify factors which determine the prognosis in the female group. Material and methods: A total of 3589 consecutive patients with CS were selected from a large, multicenter national registry on 57 400 consecutive STEMI patients. Results: Women had a greater time delay from symptom onset to treatment (admission within the first 2 h, 37.1% vs. 44.8%; p < 0.001). They were also less likely to undergo interventional treatment (40.4% vs. 48.1%; p < 0.001) and to receive coronary stenting (86.8% vs. 90.1%; p = 0.045), glycoprotein IIb/IIIa inhibitors (15.3% vs. 20.1%; p < 0.001) and clopidogrel (46.3% vs. 53.6%; p < 0.001). In the female patients in-hospital and 12-month mortality were higher than in their male counterparts (55% vs. 45.8%; p < 0.001 and 72.5% vs. 63.8%; p < 0.001, respectively). Women with cardiogenic shock were less likely to receive optimal therapy than men, which resulted in a poor clinical outcome. Conclusions: This should encourage medical professionals to apply advanced therapeutic strategies without gender bias. Only if there are no gender-related discrepancies in the management of patients with cardiogenic shock may the beneficial impact of invasive treatment be fairly assessed and the hypothesis that more guideline-adherent treatment of women results in better outcomes be validated.

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Analysis of Myocardial Infarction Time Course in Women Compared With Men in Upper Silesia Population in 30 Day Follow-Up

Cited by 3 publications

References 28 publications

Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome

Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome

Incidence of ventricular arrhythmia and associated patient outcomes in hospitalized acute coronary syndrome patients in Saudi Arabia: findings from the registry of the Saudi Project for Assessment of Acute Coronary Syndrome (SPACE)

Mortality of women with ST-segment elevation myocardial infarction and cardiogenic shock – results from the PL-ACS registry

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