Analysis of N6-methyladenosine-related lncRNAs in the tumor immune microenvironment and their prognostic role in pancreatic cancer

Liu, Yong; Wang, Tao; Fang, Ziqi; Kong, Junjie; liu, Jun

doi:10.1007/s00432-022-03985-4

Cited by 1 publication

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“…; (3) extracellular matrix (ECM) and other secretory molecules: growth factors, cytokines, chemokines, and extracellular vesicles (EVs); (4) Blood and lymphatic vascular networks. 10–13 The relationship between RNA modifications and the tumor microenvironment, especially the role of m 6 A and m 5 C modifications, has been described in many kinds of cancer subtypes such as lung adenocarcinoma, 88 , 89 pancreatic carcinoma 90 , 91 and CRC; 92 , 93 however, these studies are not in-depth and very few in number ( Figure 1 ).…”

Section: Rna Modifications In the Tumor Microenvironmentmentioning

confidence: 99%

RNA Modifications Meet Tumors

Yang¹,

Zhang²,

Xia³

et al. 2022

CMAR

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RNA modifications occur through the whole process of gene expression regulation, including transcription, translation, and post-translational processes. They are closely associated with gene expression, RNA stability, and cell cycle. RNA modifications in tumor cells play a vital role in tumor development and metastasis, changes in the tumor microenvironment, drug resistance in tumors, construction of tumor cell-cell “internet”, etc. Several types of RNA modifications have been identified to date and have various effects on the biological characteristics of different tumors. In this review, we discussed the function of RNA modifications, including N 6 -methyladenine (m 6 A), 5-methylcytosine (m 5 C), N 7 -methyladenosine (m 7 G), N 1 -methyladenosine (m 1 A), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I), in the microenvironment and therapy of solid and liquid tumors.

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