Analysis of natural product regulation of cannabinoid receptors in the treatment of human disease

Badal, Simone; Smith, Keriayn N.; Rajnarayanan, Rajendram V.

doi:10.1016/j.pharmthera.2017.06.003

Cited by 25 publications

(27 citation statements)

References 299 publications

(238 reference statements)

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“…Hence, the synergistic anti‐tumor effect of Alantolactone could help to overcome the drug resistance and sensitize the EGFR targeted therapy for PC. Although, Alantolactone has good safety and pharmacological properties as reported before, the effect of pharmacokinetics are poor. The next step we will study the nanotechnology‐based therapeutics, which could improve the Alantolactone bioavailability and tumor targetability.…”

Section: Discussionmentioning

confidence: 85%

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Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling

Zheng

Yang

Kang

et al. 2019

Molecular Carcinogenesis

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Several studies have implicated the feedback activation of signal transducer and activator of transcription 3 (STAT3) as a new cancer drug-resistance mechanism and linked it to the failure of epidermal growth factor receptor (EGFR)-targeted therapies.In this study, we discovered that Alantolactone, a natural sesquiterpene lactone, potently inhibited human pancreatic cancer cells and suppressed constitutively activated STAT3. In contrast, Alantolactone had little effect on the EGFR pathway.Moreover, combination of Alantolactone and an EGFR inhibitor, Erlotinib or Afatinib, demonstrated a remarkable synergistic anti-cancer effect against pancreatic cancer cells both in vitro and in vivo. Our results suggested that Alantolactone could sensitize human pancreatic cancer cells to EGFR inhibitors possibly through down-regulating the STAT3 signaling. Alantolactone, when combined with other EGFR targeted agents, could be further developed as a potential therapy for pancreatic cancer.

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Section: Discussionmentioning

confidence: 85%

“…Recent studies have drawn attention to the antitumor properties of natural products due to their confirmed pharmacological properties and few side effects . Alantolactone acts as an agent with active antitumor activity, which inhibits tumor cell proliferation, promotes apoptosis, and suppresses invasion and metastasis .…”

Section: Introductionmentioning

confidence: 99%

Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling

Zheng

Yang

Kang

et al. 2019

Molecular Carcinogenesis

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“…A number of studies have investigated CBD to determine its activity at cannabinoid receptors and shown very low affinity for CB1 and CB2 [ 14 ] ( Table 1 b). It was reported that CBD can act as an antagonist/inverse agonist at certain concentrations below which it binds to both CB1 and CB2 orthosteric sites [ 53 ]. Recently, several studies demonstrated that CBD can act as a negative allosteric modulator of CB1, which alters the potency and efficacy of the orthosteric ligands but does not activate the receptor itself [ 54 , 55 , 56 ].…”

Section: Phytocannabinoids and Synthetic Cannabinoidsmentioning

confidence: 99%

Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products

Peigneur

Hendrickx

et al. 2020

IJMS

143

114

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Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and CB2, resulting in hundreds of phyto- and synthetic cannabinoids which have shown varying affinities relevant for the treatment of various diseases. However, only a few of these ligands are clinically used. Recently, more detailed structural information for cannabinoid receptors was revealed thanks to the powerfulness of cryo-electron microscopy, which now can accelerate structure-based drug discovery. At the same time, novel peptide-type cannabinoids from animal sources have arrived at the scene, with their potential in vivo therapeutic effects in relation to cannabinoid receptors. From a natural products perspective, it is expected that more novel cannabinoids will be discovered and forecasted as promising drug leads from diverse natural sources and species, such as animal venoms which constitute a true pharmacopeia of toxins modulating diverse targets, including voltage- and ligand-gated ion channels, G protein-coupled receptors such as CB1 and CB2, with astonishing affinity and selectivity. Therefore, it is believed that discovering novel cannabinoids starting from studying the biodiversity of the species living on planet earth is an uncharted territory.

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“…Reseptor ini terletak di beberapa bagian tubuh terutama di otak (Mackie, 2008). Reseptor canabinoid bersama dengan ligan membentuk sistem endocannabinoid (endocannabinoid system) yang dimodulasi oleh senyawa yang terdapat pada tanaman darat dan air termasuk terpena (terpenoid) yang terkandung pada tanaman obat kipahit dan jambu biji (Badal et al, 2017).…”

Section: Hasil Dan Bahasanunclassified

STATUS KESEHATAN IKAN LELE (Clarias gariepinus) YANG MENERIMA PAKAN BERSUPLEMEN KOMBINASI DAUN SIRIH (Piper betler leaf), JAMBU BIJI (Psidium guajava leaf), DAN KIPAHIT (Tithonia diversifolia leaf)

Nafiqoh

Sukenda

Zairin

et al. 2019

Jurnal Riset Akuakultur

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Tanaman obat telah banyak digunakan sebagai bahan pencegah dan pengobatan penyakit pada ikan budidaya. Penelitian ini ditujukan untuk mengetahui status kesehatan ikan lele (C. gariepinus) yang menerima pakan dengan suplemen tanaman obat kombinasi dari daun sirih, jambu biji, dan kipahit melalui pengamatan gambaran darah dan histologi ginjal sebagai organ yang memproduksi darah. Kombinasi satu merupakan kombinasi dari ketiga daun tanaman obat masing-masing sebanyak 33%, kombinasi dua juga terdiri dari daun sirih, jambu biji, dan kipahit masing-masing sebanyak 5%:19%:76%, dan kontrol yaitu pakan tanpa penambahan tanaman obat. Gambaran darah dan histologi ginjal diamati pada minggu ketiga setelah pemberian pakan. Hasil pengamatan gambaran darah menunjukkan bahwa terdapat peningkatan jumlah sel darah merah pada ikan yang menerima pakan perlakuan dibandingkan dengan kontrol (0,4 ± 0,14). Namun tidak terdapat perbedaan nyata antara jumlah sel darah merah dari kelompok perlakuan kombinasi satu dan dua (1,5 ± 0,17 dan 1,4 ± 0,1). Jumlah sel darah putih pada kelompok perlakuan juga meningkat dibandingkan dengan kelompok kontrol (10,5 ± 0,46), namun tidak terdapat perbedaan nyata antara kelompok perlakuan kombinasi satu dan dua (15,1 ± 1,19 dan 17,6 ± 1,14). Hasil pengamatan histologi terlihat jaringan hematopoietik organ ginjal dari kelompok yang menerima perlakuan berproliferasi lebih banyak dibandingkan kelompok kontrol. Namun tidak ada pengaruh pada nilai hemoglobin dan persentase leukosit diferensiasi antara kelompok perlakuan dan kontrol. Penambahan daun tanaman obat dalam pakan ikan mampu meningkakan status kesehatan dari ikan lele.Medicinal herbs have been traditionally used as prophylactic and therapeutic supplement to treat diseases in aquaculture. This study was aimed to improve the health quality of catfish (C. gariepinus) through feeding on diets enriched with a combination of betel, guava, and tithonia as medicine by analyzing hematology and histology of kidney as blood producing organ. Diet-one was feed enrich with 33% of each plant. Diet-two was feed enriched with betel, guava, and tithonia at a proportion of 5%,19%, and 76%, respectively. Control diet was fed without the plants’ supplementation. Hematology and histology of fish kidney were observed after fish received three-week feed treatments. The results showed that there was an increase of erythrocyte levels in the treated fish groups fed with diet-one and diet-two compared with the control (0.4 ± 0.14). However, no significant differences of erythrocyte level were observed between fish groups fed with diet -one and die-two (1.5 ± 0.17 and 1.4 ± 0.1). Leucocyte levels also increased in the treated fish group with diet-one and diet-two compared to the control (10.5 ± 0.46). However, there was no significant difference of leucocyte level between the fish group feed with diet-one and diet-two (15.1 ± 1.19 and 17.6 ± 1.14). Histological observations found that there were more hematopoietic tissues in the fish kidney of proliferated treated group than the control group. However, there was no effect on hemoglobin level and leukocyte percentage differentiation between the treatment and control groups. This study concludes that medicinal herbs as enrichment ingredients in fish diet can increase the health quality of fish.

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Analysis of natural product regulation of cannabinoid receptors in the treatment of human disease

Cited by 25 publications

References 299 publications

Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling

Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling

Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products

STATUS KESEHATAN IKAN LELE (Clarias gariepinus) YANG MENERIMA PAKAN BERSUPLEMEN KOMBINASI DAUN SIRIH (Piper betler leaf), JAMBU BIJI (Psidium guajava leaf), DAN KIPAHIT (Tithonia diversifolia leaf)

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