Analysis of neurochemicals by capillary electrophoresis in athletes' urine and a pilot study of their changes responding to sport fatigue

Ma, Shuai; Xu, Zhongqi; Ren, Jie

doi:10.1039/c9ay00457b

Cited by 11 publications

(4 citation statements)

References 61 publications

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“…2,3 Consequently, an accurate and rapid method for the detection of DA in clinical diagnosis is required to investigate and develop. Several approaches, including chemiluminescence analysis (CL), 4,5 liquid chromatographic analysis (LC), 6 capillary electrophoresis analysis (CE), 7,8 and fluorescence analysis (FL), 9,10 were proposed for DA determination. Among them, the electrochemical technique has the characteristics of high accuracy and selectivity, easy apparatus, and fast response.…”

mentioning

confidence: 99%

ZIF-8 Coupling with Reduced Graphene Oxide to Enhance the Electrochemical Sensing of Dopamine

Dong

et al. 2021

J. Electrochem. Soc.

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A reduced graphene oxide@zeolitic imidazolate framework-8 (rGO@ZIF-8) based electrochemical sensor was developed and used for dopamine detection. ZIF-8 was rapidly prepared by zinc hydroxide nitrate (Zn-HDS, Zn5(OH)8(NO3)2·2H2O) as precursor. Subsequently, rGO was introduced to enhance the performance of ZIF-8 (e.g., high carrier mobility, favorable stability), and a label-free electrochemical dopamine sensor based on the composite material was obtained with high specific surface area and better conductivity verified by Brunauer–Emmett–Teller surface analysis and electrochemical impedance spectroscopy, respectively. Consequently, rGO@ZIF-8 complex exhibited an admirable electrochemical catalytic performance. For determination of dopamine, the sensor behaves wide linear range from 2.0 × 10−6 to 1.4 × 10−4 mol l−1 and lower detection limit of 2.0 × 10−8 mol l−1 (S/N = 3). It also showed sufficient repeatability and durability due to the coordinated amplification effect of rGO and ZIF-8.

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mentioning

confidence: 99%

ZIF-8 Coupling with Reduced Graphene Oxide to Enhance the Electrochemical Sensing of Dopamine

Dong

et al. 2021

J. Electrochem. Soc.

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“…6 Thus, the detection of VMA content in urine has important clinical significance for the early diagnosis and disease monitoring of pheochromocytoma. So far, several analytic methods for VMA detection, mainly including electrochemistry, 3 high performance liquid chromatography coupled with electrochemical detection (HPLC−ECD), 7 enzyme immunoassay, 8 gas chromatography−mass spectrometry (GC−MS), 9 capillary electrophoresis, 10 and liquid chromatography coupled to tandem mass spectrometry (LC−MS/ MS), 4 have been reported. These methods were accurate, while related techniques were complicated and time-consuming, and they rely on relatively expensive and complex instruments.…”

Section: ■ Introductionmentioning

confidence: 99%

Novel Lanthanide-Based Metal–Organic Framework Isomer as a Double Ratiometric Fluorescent Probe for Vanillymandelic Acid

Fan

Liu²,

Cheng

et al. 2023

ACS Appl. Mater. Interfaces

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The concentration of vanillymandelic acid (VMA) in urine is closely related with pheochromocytoma diagnosis. Thus, it is essential to develop more accurate and convenient fluorescence sensing strategies toward VMA. Until now, the design of double ratiometric detection methods for VMA was still in the unexplored stage. In this work, novel Ln3+-based metal–organic frameworks (QBA-Eu and QBA-Gd0.875Eu0.125) possessing dual emission peaks was fabricated successfully, which served as isomers of YNU-1 and exhibited more excellent water stability in fluorescence and structure than the ones of YNU-1. The formation of the complex between QBA ligands and VMA molecules via hydrogen bonds within QBA-Eu frameworks produced a new emission band centered at 450 nm and resulted in the decline of monomer emission intensity for QBA at 390 nm. Owing to the reduced energy gap [ΔE (S1 – T1)], the antenna effect was hampered and luminescence of Eu3+ ions also decreased. The developed double ratiometric (I 615nm/I 475nm, I 390nm/I 475nm) fluorescence sensors based on QBA-Eu and QBA-Gd0.875Eu0.125 possessed the advantages of fast response (4 min), low detection limits (0.58 and 0.51; 0.22 and 0.31 μM), and wide linear ranges (2–100 and 2–80 μM), which met the requirements of pheochromocytoma diagnosis. We also applied them to determine VMA in an artificial urine sample and diluted human urine sample and obtained satisfactory results. They will become prospective fluorescence sensing platforms for VMA.

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“…32 Capillary electrophoresis (CE) has been developed to determine VMA in human urine. [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] CE has attracted increased interest because of its high separation efficiency, short analysis time, small sample volume, and low reagent consumption which makes it an attractive alternative to HPLC. 34 Commercial CE instruments are equipped with UV absorbance detectors due to their low cost and simplicity of instrumentation.…”

Section: Introductionmentioning

confidence: 99%

UiO-66-based metal–organic framework for dispersive solid-phase extraction of vanillylmandelic acid from urine before analysis by capillary electrophoresis

et al. 2022

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Analysis of neurochemicals by capillary electrophoresis in athletes' urine and a pilot study of their changes responding to sport fatigue

Abstract: Neurochemicals may play an important role in metabolism and sport fatigue.

Cited by 11 publications

References 61 publications

ZIF-8 Coupling with Reduced Graphene Oxide to Enhance the Electrochemical Sensing of Dopamine

ZIF-8 Coupling with Reduced Graphene Oxide to Enhance the Electrochemical Sensing of Dopamine

Novel Lanthanide-Based Metal–Organic Framework Isomer as a Double Ratiometric Fluorescent Probe for Vanillymandelic Acid

UiO-66-based metal–organic framework for dispersive solid-phase extraction of vanillylmandelic acid from urine before analysis by capillary electrophoresis

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