2022
DOI: 10.1556/1326.2021.00924
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Analysis of neurotransmitter catecholamines and related amines in human urine and serum by chromatography and capillary electrophoresis with 1, 3, 5, 7-tetramethyl-8-(N-hydroxysuccinimidyl propionic ester)-difluoro-boradiaza-s-indacene

Abstract: Two sensitive and effective methods were developed for the detection of catecholamines and related biogenic amines (dopamine, epinephrine, norepinephrine, serotonin, levodopa and tyramine) using high performance liquid chromatography with fluorescence detection and capillary electrophoresis with laser-induced fluorescence detection. A BODIPY fluorescent dye, 1, 3, 5, 7-tetramethyl-8-(N-hydroxysuccinimidyl propionic ester)-difluoroboradiaza- s-indacene was used as pre-column derivatization reagent. The separati… Show more

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Cited by 6 publications
(3 citation statements)
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“…7,8 Lastly, lower levels of acetylcholine are associated with Alzheimer's disease, 9 while lower levels of norepinephrine are associated with depression. 10 Quantitative analyses of these neurotransmitters are typically achieved using methods such as high-performance liquid chromatography (HPLC), [11][12][13] electrochemical methods, 14,15 uorescence, 16 etc. However, these methods suffer from various limitations, such as being restricted to use with off-site analytes and the inability to accomplish instantaneous identication.…”
Section: Introductionmentioning
confidence: 99%
“…7,8 Lastly, lower levels of acetylcholine are associated with Alzheimer's disease, 9 while lower levels of norepinephrine are associated with depression. 10 Quantitative analyses of these neurotransmitters are typically achieved using methods such as high-performance liquid chromatography (HPLC), [11][12][13] electrochemical methods, 14,15 uorescence, 16 etc. However, these methods suffer from various limitations, such as being restricted to use with off-site analytes and the inability to accomplish instantaneous identication.…”
Section: Introductionmentioning
confidence: 99%
“…The most used methods for their determination are liquid chromatography with tandem mass spectrometry (LC-MS/MS) [ 1 , 2 , 3 , 4 ], liquid chromatography with electrochemical detection (LC-ECD) [ 13 , 14 , 15 ] and liquid chromatography with ultraviolet (LC-UV) or fluorometric detection (LC-FLD) [ 16 , 17 , 18 , 19 , 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…Overall, derivatization [ 2 , 3 ] is preferable for the determination of such polar and small molecules as catecholamines. The above-mentioned reagents, namely, FMOC-Cl and dansyl chloride, require at least 30 min for reaction and the presence of an alkali [ 18 , 19 ]. It leads to a high degradation speed of some analytes (including catecholamines) and requires neutralization of the alkali in a final step of the sample preparation procedure.…”
Section: Introductionmentioning
confidence: 99%