Analysis of non-coding small RNA similarity/sharing between plant and animal genomes

Huang, Fengming; Qiao, Xiangyu; Song, Moshi; Zhang, Cong; Jiang, Chengyu

doi:10.1007/s11427-022-2373-8

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…8,9,14 Previous studies have demonstrated favorable biocompatibility and effectiveness, establishing them as innovative methods for delivering nucleic acids orally. [14][15][16]32,33,35 However, the field is FENG ET AL.…”

Section: Discussionmentioning

confidence: 99%

“…30 In response, Jiang's group reported the similarity/shared characteristics between plant and animal non-coding sRNA, revealing some shared RNA sequences, suggesting possible cross-kingdom sharing between plant and animal genomes. [31][32][33] It's worth mentioning that traditional Chinese medicine is effective in treating patients with COVID-19 in China, but the specific mechanism is complex and challenging to clarify. 34 Interestingly, Jiang's group first reported that in the peripheral blood mononuclear cells (PBMCs) samples of COVID-19 patients treated with traditional Chinese medicine, many sRNAs derived from herbal sources were identified.…”

Section: Controversy Regarding Nucleic Acid Molecules Originating Fro...mentioning

confidence: 99%

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Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy

Feng,

Ahmed,

Ahmed

et al. 2024

Interdisciplinary Medicine

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A significant number of nucleic acid therapies have been approved, highlighting the vast potential of nucleic acid therapeutics. Although numerous delivery strategies have been investigated, and progress has been made in nucleic acid delivery systems, the oral delivery route still presents a significant obstacle. Recently, a novel and promising force in oral nucleic acid delivery has emerged, namely Decoctosomes and Bencaosomes, obtained from the decoction of natural herbs, which refers to boiled Chinese herbal medicines. The active components of Decoctosomes include small molecules, peptides, and small RNAs (sRNAs). sRNAs were the first targets of extensive research. Additionally, Bencaosomes have been proven effective in several disease mouse models as artificially enhanced decoctosome products. This perspective summarizes the development and possible future directions of Decoctosomes and Bencaosomes, two varieties of nanoparticles that may open the door to new possibilities in nucleic acid therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Controversy Regarding Nucleic Acid Molecules Originating Fro...mentioning

confidence: 99%

Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy

Feng,

Ahmed,

Ahmed

et al. 2024

Interdisciplinary Medicine

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“…Using the reindeer genome as a reference, whole-genome alignments were generated for these 16 species. The methods in detail are the same as in previous studies ( Frith & Ni, 2023 ; Huang et al, 2023 ; Wang et al, 2023 ; Wu et al, 2021 , 2023 ); LASTZ ( Nahar et al, 2021 ) was first used for alignments with maf format, and MULTIZ ( waterman & bell, 1984 ) was used to integrate the alignments for different species. Then, those noncoding sequences remained in other 15 vertebrates with over 80% similarity, but lost in reindeer genome, may be the reindeer-specific missing conserved noncoding elements (CNEs).…”

Section: Methodsmentioning

confidence: 99%

Resequencing of reindeer genomes provides clues to their docile habits

Wu,

Ren,

Yan

et al. 2024

Evolution Letters

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Reindeer have long been served as vital subsistence resources for inhabitants of Arctic and subarctic regions owing to their domestication. However, the evolutionary relationships and divergence times among different reindeer populations, genetic traits that distinguish domesticated reindeer, and factors that contribute to their relative docility compared with that of other Cervidae specie, remain unclear. In this study, we sequenced the genomes of 32 individuals from wild and domestic reindeer populations that inhabit Arctic and subarctic regions. We found that reindeer experienced 2 or more independent domestication events characterized by weak artificial selection pressure and limited significant differences in genomic parameters between wild and domestic populations. Alterations in conserved noncoding elements in the reindeer genomes, particularly those associated with nervous system development, may have contributed to their domestication by rendering the nervous system less responsive. Together, our results suggest that inherent species-specific traits, rather than intense artificial selection, may have played a significant role in the relatively docile behavior of reindeer and offer valuable insights into the domestication process of these animals.

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Potential oligonucleotide drugs in Bencao sRNA Atlas

Huang

Liu

et al. 2023

Sci. China Life Sci.

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Analysis of non-coding small RNA similarity/sharing between plant and animal genomes

Cited by 4 publications

References 9 publications

Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy

Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy

Resequencing of reindeer genomes provides clues to their docile habits

Potential oligonucleotide drugs in Bencao sRNA Atlas

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