Analysis of nonspecific oral mucosal and dermal lesions suggestive of syphilis: a report of 6 cases

Reemerging syphilis

“…In this phase, several systemic and mucocutaneous manifestations of the disease, such as fever, malaise, weight loss, pharyngitis, and lymphadenopathy 5,6,14,15 occur. Some of these events were reported by our patient, additionally to hair, eyebrows, and eyelashes loss, which have been reported in about 5-6% of the patients with syphilis 5 .…”

“…It is characterized by a painless ulcer called hard chancre that occurs at the site of inoculation, heals spontaneously, and is classically located in the genital region. Although not common, hard chancre can also be extragenital and affect mainly anal or oral sites 5,6 . After 2 to 12 weeks after the primary infection, the treponemes spread through blood and lymphatic vessels 6,7 giving rise to the secondary syphilis phase, characterized by widely variable systemic and oral manifestations.…”

“…Although not common, hard chancre can also be extragenital and affect mainly anal or oral sites 5,6 . After 2 to 12 weeks after the primary infection, the treponemes spread through blood and lymphatic vessels 6,7 giving rise to the secondary syphilis phase, characterized by widely variable systemic and oral manifestations. The classic cutaneous manifestation of this phase is the maculopapular rash that often involves the palms and soles 6 .…”

“…After 2 to 12 weeks after the primary infection, the treponemes spread through blood and lymphatic vessels 6,7 giving rise to the secondary syphilis phase, characterized by widely variable systemic and oral manifestations. The classic cutaneous manifestation of this phase is the maculopapular rash that often involves the palms and soles 6 . Oral lesions occur more frequently at this stage of the disease, and their clinical aspects can be quite heterogeneous [4][5][6] .…”

“…The classic cutaneous manifestation of this phase is the maculopapular rash that often involves the palms and soles 6 . Oral lesions occur more frequently at this stage of the disease, and their clinical aspects can be quite heterogeneous [4][5][6] . Tertiary syphilis, which occurs after a highly variable latent period, presents severe complications that may involve different systems.…”