Abstract-For clean signal, noise cancellation techniques are explored day-by-day. At the user end the clean signal is highly essential for different purposes. In this authors have considered the bio-medical signal that is corrupted with impulsive noise. It is very important to separate from the signal, as its occurrence is sudden and often similar to the signal. The popular adaptive algorithms have been tested for cancellation of impulsive noise. Further most used Wilcoxon LMS is also verified for impulsive noise case. Finally it has been modified for the same purpose. The result found excellent in terms of less MSE, SNR improvement and faster convergence.