In this paper author have targeted to detect various kinds of adulteration/contamination in camel, cow and buffalo milk using surface plasmon resonance (SPR) technique. SPR technique have numerous features like its label free technique, provide real time analysis and able to detect very minute change in sample’s physical condition from its ideal condition. The change in sample physical condition change can estimate using change in refractive index. The adulteration in milk does for financial benefits but they are highly dangerous for health especially for children and pregnant women. Some more contamination added knowingly as a preservative but they affect the purity of milk so that their detection is essential. In this paper author have targeted to detect mainly urea, melamine, Salmonella and coconut oil in milk by using a Kretschmann configuration based SPR sensor. The sensor consists of high refractive index prism (ZnSe) as a dielectric substrate, gold (Au) nanolayer, Graphene monolayer and heterostructure of BlueP/MoS2. Major performance parameters like sensitivity, Figure of Merit (FoM), Detection accuracy and limit of detection also calculated for each case to validate the result of proposed sensor. The performance of sensor is done in visible region in theoretical way using analytical software MATLAB.