Analysis of ocular surface damage and visual impact in patients with primary and secondary Sjögren syndrome

Villarreal-Gonzalez, Antonio J; Rivera-Alvarado, I Jocelyn; Rodríguez-Gutiérrez, Luis Alberto; Rodríguez-García, Alejandro

doi:10.1007/s00296-020-04568-7

Cited by 14 publications

(10 citation statements)

References 32 publications

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“…83 This test is crucial for women with severe dry eye accompanied by dry mouth, joint pain, chronic fatigue, and a highly suspected or confirmed autoimmune condition. 85 , 86 The Panel suggested a Schirmer-I test result of ≤5mm/5min is considered severe, ≤10mm/5min moderate, and ≥10mm/5min normal. 87 …”

Section: Resultsmentioning

confidence: 99%

A Practical Approach to Severity Classification and Treatment of Dry Eye Disease: A Proposal from the Mexican Dry Eye Disease Expert Panel

Rodríguez-García¹,

Babayán-Sosa²,

Ramírez-Miranda³

et al. 2022

OPTH

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Section: Resultsmentioning

confidence: 99%

A Practical Approach to Severity Classification and Treatment of Dry Eye Disease: A Proposal from the Mexican Dry Eye Disease Expert Panel

Rodríguez-García¹,

Babayán-Sosa²,

Ramírez-Miranda³

et al. 2022

OPTH

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“…Ocular surface staining is an important clinical parameter used to determine DED in SS patients. 41 , 42 Lissamine green staining highlights damaged corneal epithelium and devitalized cells to which it binds on the ocular surface. 42 Using this approach, we determined that both sexes of six-, 10-, and 16-week-old NOD.H-2 h4 and NOD.H-2 h4 DKO mice exhibit ocular surface damage ( Figs.…”

Section: Resultsmentioning

confidence: 99%

Early Dry Eye Disease Onset in a NOD.H-2^h4 Mouse Model of Sjögren's Syndrome

Jasmer

Camden

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose To develop a mouse model of human dry eye disease (DED) for investigation of sex differences in autoimmune-associated dry eye pathology. Methods Ocular surface disease was assessed by quantifying corneal epithelial damage with lissamine green stain in the NOD.H-2 h4 ,IFNγ − / − ,CD28 − / − (NOD.H-2 h4 DKO) mouse model of Sjögren's syndrome (SS). Lacrimal gland function was assessed by tear volume quantification with phenol red thread and lacrimal gland inflammation (i.e., dacryoadenitis) was assessed by quantification of immune cell foci, flow cytometric analysis of immune cell composition, and expression of proinflammatory markers. Results The NOD.H-2 h4 DKO mouse model of SS exhibits greater age-dependent increases in corneal damage than in NOD.H-2 h4 parental mice and demonstrates an earlier disease onset in females compared to males. The severity of ocular surface disease correlates with loss of goblet cell density, increased conjunctivitis, and dacryoadenitis that is more pronounced in NOD.H-2 h4 DKO than NOD.H-2 h4 mice. B cells dominate lacrimal infiltrates in 16-week-old NOD.H-2 h4 and NOD.H-2 h4 DKO mice, but T helper cells and macrophages are also present. Lacrimal gland expression of proinflammatory genes, including the P2X7 and P2Y 2 purinergic receptors, is greater in NOD.H-2 h4 DKO than NOD.H-2 h4 mice and correlates with dacryoadenitis. Conclusions Our results demonstrate for the first time that autoimmune dry eye disease occurs in both sexes of NOD.H-2 h4 DKO and NOD.H-2 h4 mice, with earlier onset in female NOD.H-2 h4 DKO mice when compared to males of the same strain. This study demonstrates that both NOD.H-2 h4 and NOD.H-2 h4 DKO mice are novel models that closely resemble SS-related and sex-dependent DED.

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“…LLT, blinking pattern, and meibomian gland images were assessed using the LipiView II (TearScience, Morrisville, NC, USA) ocular surface interferometer. In recent years, thanks to the development of the ocular surface interferometer, an increased number of studies regarding the tear lipid layer in dry eye patients have been published [31][32][33]. It has been hypothesized that the alteration of the lipid layer of tears caused by chronic inflammation and the dysfunction of the meibomian glands may be linked to three factors: (1) peri-glandular fibrosis, inflammation of the lacrimal glands, including the meibomian glands, linked to systemic inflammatory disease; (2) reduced mobility of the eyelids due to fibrosis of the connective tissue, which causes incomplete blinking; and (3) increased osmolarity due to greater evaporation of tears from the ocular surface, which is a consequence of the thinning of the lipid layer [28,34,35].…”

Section: Discussionmentioning

confidence: 99%

Dry Eye in Systemic Sclerosis Patients: Novel Methods to Monitor Disease Activity

et al. 2020

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Background: In systemic sclerosis (SSc) patients, dry eye syndrome (DES) is the most frequent ocular feature. The aim of this study was to investigate ocular DES-related SSc patients and to establish any correlation with the severity of the disease. Methods: Retrospectively, data from 60 patients with SSc underwent ophthalmic examination, where non-invasive film tear break-up time (NIF-TBUT), tear film lipid layer thickness (LLT), anesthetic-free Schirmer test I, tear osmolarity measurement (TearLab System), and modified Rodnan skin score (mRSS) data were collected. The visual analog scale (VAS) and Symptom Assessment in Dry Eye (SANDE) methods were utilized. The results were correlated with mRSS and the duration of SSc. Results: Severe DES occurred in 84% of cases, and was more severe in women. The eyelids were involved in 86.6%, secondary to meibomian gland disease (MGD). A direct correlation was found between the tear osmolarity (mean 328.51 ± 23.8 SD) and skin score (mRSS) (r = 0.79; p < 0.01). Significantly reduced NIF-TBUT, LLT, and Schirmer test I values were observed in the case of severe skin involvement. Conclusions: SSc patients show lipid tear dysfunction related to the severity and duration of the disease due to inflammation and the subsequent atrophy of the meibomian glands.

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Analysis of ocular surface damage and visual impact in patients with primary and secondary Sjögren syndrome

Cited by 14 publications

References 32 publications

A Practical Approach to Severity Classification and Treatment of Dry Eye Disease: A Proposal from the Mexican Dry Eye Disease Expert Panel

A Practical Approach to Severity Classification and Treatment of Dry Eye Disease: A Proposal from the Mexican Dry Eye Disease Expert Panel

Early Dry Eye Disease Onset in a NOD.H-2^h4 Mouse Model of Sjögren's Syndrome

Dry Eye in Systemic Sclerosis Patients: Novel Methods to Monitor Disease Activity

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Analysis of ocular surface damage and visual impact in patients with primary and secondary Sjögren syndrome

Cited by 14 publications

References 32 publications

A Practical Approach to Severity Classification and Treatment of Dry Eye Disease: A Proposal from the Mexican Dry Eye Disease Expert Panel

A Practical Approach to Severity Classification and Treatment of Dry Eye Disease: A Proposal from the Mexican Dry Eye Disease Expert Panel

Early Dry Eye Disease Onset in a NOD.H-2h4 Mouse Model of Sjögren's Syndrome

Dry Eye in Systemic Sclerosis Patients: Novel Methods to Monitor Disease Activity

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Early Dry Eye Disease Onset in a NOD.H-2^h4 Mouse Model of Sjögren's Syndrome