Analysis of ovarian reserve markers (AMH, FSH, AFC) in different age strata in IVF/ICSI patients

Tehraninezhad, E Shahrokh; Mehrabi, Fatemeh; Taati, Raheleh; Kalantar, Vahid; Aziminekoo, Elham; Tarafdari, Azam

doi:10.29252/ijrm.14.8.501

Cited by 32 publications

(24 citation statements)

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“…However, the low success rate and high abortion rate for IVF bring tremendous pressure and pain to countless families. Although related factors including age, endocrine, immune, and infection have been recognized (28), little work is done to explore the connection between vaginal microbiota and IVF.…”

Section: Discussionmentioning

confidence: 99%

The Disordered Vaginal Microbiota Is a Potential Indicator for a Higher Failure of in vitro Fertilization

Kong

Shang

et al. 2020

Front. Med.

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Infertility is one of the most common reproductive system diseases, and no effective method is available for its treatment. Although in vitro fertilization (IVF) has been widely used to enhance the clinical pregnancy outcome of infertility, the unsatisfied pregnancy rate with unknown reasons is obtained. To identify the possible cause of IVF failure, 555 patients were enrolled in the present study to determine their relevant clinical characteristics and vaginal microbiota. Our results indicated that the age and endometrium thickness significantly affected the pregnancy success rate of pregnant patients (P group) and non-pregnant patients (NP group) receiving IVF, and high values of luteinizing hormone, estrogen and progesterone were observed from P group. Furthermore, the Partial Least Squares Discriminant Analysis (PLS-DA) indicated a different microbial composition in P group and NP group, and a higher microbial abundance had been identified in non-pregnant patients compared with pregnant patients. At phylum level, a higher abundance of Firmicutes and Proteobacteria, and a lower abundance of Actinobacteria, Fusobacteria, and Bacteroidetes were obtained in pregnant patients compared with non-pregnant patients. At genus level, a lower abundance of the probiotic Lactobacillus, and higher abundance of pathogens Gardnerella and Prevotella were identified from non-pregnant patients. Therefore, the disordered microbiota, characterizing by the reduction of probiotics and overgrowth of pathogens in non-pregnant patients, may be used as a potential indicator for a higher IVF failure rate.

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Section: Discussionmentioning

confidence: 99%

The Disordered Vaginal Microbiota Is a Potential Indicator for a Higher Failure of in vitro Fertilization

Kong

Shang

et al. 2020

Front. Med.

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“…In contrast, the results of 2 studies showed that AMH was inversely correlated with women's age which means that women's higher age reduced ovarian reserve (21,25). In a recent study, AMH could predict ovarian reserve in different age groups; however, female age was found to be a better predictor of IVF outcome than AMH (17).…”

Section: Discussionmentioning

confidence: 87%

In Vitro Fertilization Success and Associated Factors: A Prospective Cohort Study

Azmoudeh¹,

Shahraki²,

Hoseini³

et al. 2017

International Journal of Women’s Health and Reproduction Scienc

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Introduction Infertility which is defined as the inability to get pregnant after one year of unprotected sex is affecting near 20% of couples worldwide and 25% of couples in developing countries (1,2). Mental, physical, sexual, and social aspects of infertile couples' lives are affected by infertility (3-5), addressing the necessity of proper intervention. Advances in assisted reproductive technology (ART) for infertile couples has made fast progress since 1976 and researchers have tried to find suitable treatment options for each infertile couple (6). Advances in ART improved the outcomes of in vitro fertilization/embryo transfer (IVF/ET) in recent years; however, the pregnancy rate has not exceeded 40% per treatment cycle yet (7). In addition to some demographic factors such as ethnicity, the cause of infertility, age, subfertility duration, parity (8-10), and lifestyle factors (11), oocytes retrieved (9), endometrial thickness (8), the number of embryos transferred (12) and quality of blastocysts (10) are considered as important factors in ART success. Furthermore, elevated basal follicle stimulating hormone (FSH), low number of antral follicles and premature luteinization may negatively affect ART outcomes (9,13). IVF practices were introduced to Iran in 1987. By now, several centers and clinics have been established and ART is performed widely in Iran (14). Although the role of several factors in IVF success has been investigated in western countries, few studies in Iran examined important factors in IVF success in Iranian women (4,15-17). In addition, no study evaluated the independent effects of the involving factors. We designed this study to evaluate the role of different factors in IVF success in infertility center of Moheb Yas hospital, Iran. Materials and Methods Study Design, Patient Selection, and Stimulation Protocol This prospective cohort study conducted in the infertility center of Moheb Yas hospital, affiliated to Tehran University of Medical Sciences, between March 2015 and March 2016. The convenient sampling method was used to include 160 infertile women in the study. The inclusion criteria were healthy candidates for IVF/ICSI, and FSH and LH less than 10 which is measured on the third day of the menstrual cycle. The exclusion criteria were a history of endometriosis, ovarian surgery or pelvic radiotherapy, anti-Mullerian hormone (AMH) <0.05 measured on

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“…Also in a recent study done by Tehraninezhad et al it was found that in different age groups when measuring AFC, AMH and basal FSH levels they all assist prediction of outcome variables including oocytes number, frozen\fresh embryo, chemical and clinical pregnancy but, AFC was more accurate (29) .…”

Section: Discussionmentioning

confidence: 99%

Antral Follicle Count versus Basal Follicle Stimulating Hormone as Predictors of Ovarian Response in Women Undergoing Superovulation with Long Protocol for Assisted Reproduction

El-Maeboud

Elbohoty

El-Alim

et al. 2017

Egyptian Journal of Hospital Medicine

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Background: the prediction of ovarian response before undertaking the expensive IVF treatment is quite important; it seemed that Patient characteristics, rather than the stimulation protocol are the determinant of the individual response. Advance identification of patient who will elicit a poor response or hyper response to standard treatment would be of great clinical advantage. Several parameters have been postulated as predictors of the ovarian response. Aim of work: to compare between bFSH and AFC in predicting the ovarian response in women undergoing super-ovulation with long protocol for assisted reproduction. Patients and Methods: this is an observational cohort study that included 80 infertile women who performed IVF/ICSI. It took place at Assisted Reproductive Technology (ART) Unit. Ain shams University Maternity hospital. No extra interventional measures were taken in the study apart from routine investigations and procedures done during ART therapy, being already approved in signed consent to undergo treatment. Patients who are fulfilling the inclusion and exclusion criteria were enrolled in the study. They all underwent superovulation with long GnRH agonist. They were followed up through the stimulation protocol steps, then data were analysed. Results: all basal measured data such as Age p. value =0.035, AFC p. value =0.000, basal FSH p. value =0.000 and basal E2 p. value =0.020 showed statistical significant difference between the good responders and poor responders when both groups were compared, When we apply ROC curve to compare between AFC and basal FSH as regards both (good and poor responders) to detect which one of them is better, there was no statistical significance difference between them with p. value = 0.371, the best cut off point for AFC as a predictor for good responders was found > 3 follicles with sensitivity of 90.5%, specificity of 94.1% and area under curve (AUC) of 97.5%, while while the best cut off point for basal FSH level was found ≤ 8 with sensitivity of 77.78%, specificity of 100% and AUC of 93.7%. Conclusion: AFC and basal FSH are good predictors of ovarian response in women undergoing superovulation with long protocol. There was no absolute superiority of AFC on basal FSH in predicting ovarian response. Age and basal E2 are also considered good predictors of ovarian response.

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Analysis of ovarian reserve markers (AMH, FSH, AFC) in different age strata in IVF/ICSI patients

Cited by 32 publications

References 24 publications

The Disordered Vaginal Microbiota Is a Potential Indicator for a Higher Failure of in vitro Fertilization

The Disordered Vaginal Microbiota Is a Potential Indicator for a Higher Failure of in vitro Fertilization

In Vitro Fertilization Success and Associated Factors: A Prospective Cohort Study

Antral Follicle Count versus Basal Follicle Stimulating Hormone as Predictors of Ovarian Response in Women Undergoing Superovulation with Long Protocol for Assisted Reproduction

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