Analysis of oxygen uptake efficiency parameters in young people with cystic fibrosis

Tomlinson, Owen W.; Barker, Alan R.; Chubbock, L. V.; Stevens, Daniel; Saynor, Zoe L.; Oades, Patrick; Williams, Craig A.

doi:10.1007/s00421-018-3926-8

“…The current study found mean peak VO 2 values of 1.51 L/min, close to a recent study that showed a peak VO 2 of 1.74 L/min in CF children, with a mean age of 13 years old 22 . In our study, we observed that half of children and adolescents with CF had peak VO 2 values above 80% of predicted.…”

Section: Discussionsupporting

confidence: 89%

“…Tomlinson et al 22 , evaluated 72 children and adolescents, the CF group had mild and moderate pulmonary disease and the healthy group was matched for age and gender, in order to compare the responses of oxygen uptake during CPET. This study demonstrated CPET may be a predictor of prognosis for these patients, as lower FEV 1 correlated strongly with lower peak VO 2 .…”

Section: Discussionmentioning

confidence: 99%

Maximum Exercise Capacity, Lung Function and Body Composition in Children With Cystic Fibrosis

Motter

¹

,

Cardoso

²

,

Taffarel

³

et al. 2020

Preprint

0

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Objective: To evaluate the oxygen uptake at peak exercise (VO2 peak) and to correlate with lung volume and capacity and body composition of children and adolescents with cystic fibrosis (CF). Methodology: Cross-sectional study with CF patients treated at the pediatric pulmonology outpatient clinic of a public hospital in Porto Alegre, aged [?] 7 years up to 18 years.Study assessments included: cardiopulmonary stress testing, plethysmography, and body composition assessment using body bioimpedance. Results: Thirty patients were studied, with a mean peak VO2 of 1.511 ± 0.539 liters in the population studied. Correlation analysis showed a strong correlation between peak VO2 in liters and lean mass (r = 0.77 and p <0.001), and strong and inverse correlation with fat percentage (r = -0.77 and p <0.001). ), a strong correlation with forced vital capacity (FVC) in liters (r = 0.72 and p <0.001) and forced expiratory volume in the first second (FEV1) also in liters (r = 0.69 and p <0.001). We observed a strong correlation between load (W) and lean mass and during CPET (r = 0.64 and p <0.001), and inversely with fat percentage (r = -0.64 and p <0.001). This study showed that patients with higher lean body composition have a better performance on cardiopulmonary testing, contributing to greater exercise tolerance.

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“…The main outcome of aerobic capacity is the peak oxygen uptake (VO 2 peak), defined as the maximum amount of oxygen that can be absorbed during exercise . Cardiopulmonary exercise testing (CPET) is considered the gold standard for the assessment of physical fitness, evaluating the interaction of cardiovascular, respiratory, and metabolic systems . However, the performance of CPET is still not available in many CF centers due to the need of high cost equipment (treadmill or cycle ergometer and a gas analysis system) and highly trained staff.…”

Section: Introductionmentioning

confidence: 99%

Prediction of peak oxygen uptake using the modified shuttle test in children and adolescents with cystic fibrosis

Vendrusculo

¹

,

Heinzmann‐Filho

²

,

Campos

³

et al. 2019

Pediatric Pulmonology

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Background: Several tests may be used to assess exercise intolerance in cystic fibrosis (CF), including the gold standard cardiopulmonary exercise test (CPET) and the Modified Shuttle Test (MST).Objective: To evaluate the use of the MST as a predictor of peak oxygen uptake (VO 2 peak) and to compare VO 2 peak and maximal heart rate (HRmax) obtained in both tests.Methods: Cross-sectional study including individuals with CF aged between 6 and 20 years old. Participants who were unable to perform the tests and/or presented signs of pulmonary exacerbation were excluded. Demographic, anthropometric, clinical and spirometric values were collected. CPET and the MST were performed in two consecutive outpatient visits. HRmax, peripheral oxygen saturation, dyspnea, and VO 2 peak measured and estimated were compared.Results: Twenty-four patients, mean age 15.7 ± 4.2 years and FEV 1 (% predicted) 76.4 ± 23.8, were included. Mean values of HRmax (bpm) and HRmax in percent of predicted (HRmax%) were lower (P = 0.01) in the MST (171.6 ± 14.5 and 87.1 ± 7.5) compared to CPET (180.9 ± 10.0 and 91.9 ± 5.4). However, there was no significant differences between tests in the variation (delta) for HRmax and HRmax% (P = 0.17). A strong correlation (r = 0.79; P < 0.0001) was found between distance achieved (MST) and VO 2 peak (CPET). The regression model to estimate VO 2 peak resulted in the following equation: VO 2 (mL · kg −1 · min −1 ) = 20.301 + 0.019 × MST distance (meters). There was no difference (P = 0.50) between VO 2 peak measured (CPET) and estimated by the equation. Conclusion:The MST may be an alternative method to evaluate exercise capacity and to predict VO 2 peak in children and adolescents with CF.

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“…However, allometric scaling can produce size‐independent expressions of peak

and should be considered when analyzing physiological data in clinical research. Allometric scaling has been successfully utilized in other clinical populations who have an altered body composition, such as people with cystic fibrosis 29 , 41 but not yet in people with other types of ConHD. The scaling coefficients derived from the current study should not be applied to other populations.…”

Section: Discussionmentioning

confidence: 99%

Scaling Peak Oxygen Consumption for Body Size and Composition in People With a Fontan Circulation

Wadey

¹

,

Barker

²

,

Stuart

³

et al. 2022

JAHA

Self Cite

4

0

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Background Peak oxygen consumption (peak V ̇ O 2 $$ \dot{\mathrm{V}}{\mathrm{O}}_2 $$ ) is traditionally divided (“ratio‐scaled”) by body mass (BM) for clinical interpretation. Yet, it is unknown whether ratio‐scaling to BM can produce a valid size‐independent expression of peak V ̇ O 2 $$ \dot{\mathrm{V}}{\mathrm{O}}_2 $$ in people with a Fontan circulation. Furthermore, people with a Fontan circulation have deficits in lean mass, and it is unexplored whether using different measures of body composition may improve scaling validity. The objective was to assess the validity of different scaling denominators (BM, stature, body surface area, fat‐free mass, lean mass, and appendicular lean mass using ratio and allometric scaling). Methods and Results Eighty‐nine participants (age: 23.3±6.7 years; 53% female) with a Fontan circulation had their cardiorespiratory fitness and body composition measured by cardiopulmonary exercise testing and dual‐energy x‐ray absorptiometry. Ratio and allometric (log‐linear regression) scaling was performed and Pearson correlations assessed scaling validity. Scaling denominators BM ( r =−0.25, P =0.02), stature ( r =0.46, P <0.001), and body surface area (0.23, P =0.03) were significantly correlated with their respective ratio‐scaled expressions of peak V ̇ O 2 $$ \dot{\mathrm{V}}{\mathrm{O}}_2 $$ , but fat‐free mass, lean mass, or appendicular lean mass were not ( r ≤0.11; R 2 =1%). Allometrically expressed peak V ̇ O 2 $$ \dot{\mathrm{V}}{\mathrm{O}}_2 $$ resulted in no significant correlation with any scaling denominator ( r =≤0.23; R 2 =≤4%). Conclusions The traditional and accepted method of ratio‐scaling to BM is invalid because it fails to create a size‐independent expression of peak V ̇ O 2 $$ \dot{\mathrm{V}}{\mathrm{O}}_2 $$ in people with a Fontan circulation. However, ratio‐scaling to measures of body composition (fat‐free mass, lean mass, and appendicular lean mass) and allometric techniques can produce size‐independent expressions of peak V ̇ O 2 $$ \dot{\mathrm{V}}{\mathrm{O}}_2 $$ in people with a Fontan circulation.

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Analysis of oxygen uptake efficiency parameters in young people with cystic fibrosis

Cited by 9 publications

References 37 publications

Maximum Exercise Capacity, Lung Function and Body Composition in Children With Cystic Fibrosis

Maximum Exercise Capacity, Lung Function and Body Composition in Children With Cystic Fibrosis

Prediction of peak oxygen uptake using the modified shuttle test in children and adolescents with cystic fibrosis

Scaling Peak Oxygen Consumption for Body Size and Composition in People With a Fontan Circulation

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