Wireless closed-loop control systems, so-called networked control systems (NCS) promise technical and economic benefits for production applications. To realize prospective benefits, the right communication technology is key. The fifth generation of mobile communication is predicted to have a significant impact on the deployment of NCS in the industrial connectivity landscape. However, there are different options for 5G deployment influencing both technical performance and economic aspects of the network. This in turn is expected to have a techno-economic influence on the production itself. Thus, a trade-off between the necessary technical performance of the 5G network and the benefits for the production must be executed. This paper, therefore, aims to analyze the techno-economic benefits of 5G deployment for closed-loop control systems in production. To reach this aim, first, the fundamentals of techno-economic analysis are introduced. Second, the results of an experimental performance analysis of a 5G-NSA-NPN at Fraunhofer IPT in Aachen are shown. Third, based on the results from the experimental study, a model-based techno-economic ex-ante evaluation of 5G-NSA-NPN for closed-loop applications is performed, and an exemplar is shown for a BLISK milling use case. Finally, the results are summarized and an outlook for further research is given. The analysis shows a difference in net present value for 5G deployment of EUR 2.6 M after 10 years and a difference of OPEX per product of around EUR −1000 per BLISK. Furthermore, analysis shows an increase in productivity (0.73%), quality (30.75%), and sustainability (2.87%). This indicates a noticeable improvement of a 5G-controlled NCS.