Analysis of paralytic shellfish toxins, potential chemical threat agents, in food using hydrophilic interaction liquid chromatography–mass spectrometry

Jansson, Daniel; Åstot, Crister

doi:10.1016/j.chroma.2015.09.029

Cited by 35 publications

(9 citation statements)

References 29 publications

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“…The results were in accordance with official reference methods and the sensitivity was better than that obtained by the official PSP toxin methods [78]. Another HILIC LC-MS/MS method for the analysis of PSP toxins was recently tested for several different food matrices from a forensic perspective [79].…”

Section: Review and Discussion Of Trends In Analytical Methods For Bisupporting

confidence: 51%

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology

Dorner

Zeleny

Harju

et al. 2016

TrAC Trends in Analytical Chemistry

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Section: Review and Discussion Of Trends In Analytical Methods For Bisupporting

confidence: 51%

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology

Dorner

Zeleny

Harju

et al. 2016

TrAC Trends in Analytical Chemistry

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“…The theoretical detection limit of STX, which was defined as the amount/concentration necessary to yield a net signal equals to three times the standard deviation of the background (3σ/S), is 0.38 fmol (3.8×10 −9 M, 100 nL sample injection), and the RSD of five reduplicate detections (for 2.0×10 −7 M STX) is 7%. In comparison with conventional methods such as LC/LC‐MS and ELISA , the proposed method has obvious analytical advantages such as higher sensitivity, lower detection limit, low cost, and so on. The success of this study provides an alternative to precise quantification of ultra‐trace STX in seafood samples, and further expands the application of ICP‐MS.…”

Section: Resultsmentioning

confidence: 99%

“…At present, the main techniques used for the analysis of STX in seafood and aqueous environment are LC/LC‐MS and ELISA . However, LC and LC‐MS methods require complicated pretreatment and have relative low sensitivity, and ELISA has relatively high cost, lower sensitivity, and poor stability due to the utilization of antibody although it is easy to use and has a better specificity.…”

Section: Introductionmentioning

confidence: 99%

Capillary electrophoresis inductively coupled plasma mass spectrometry combined with metal tag for ultrasensitively determining trace saxitoxin in seafood

Chen

et al. 2016

Electrophoresis

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As one of paralytic shellfish toxins, the saxitoxin (STX) in the aqueous environment can be accumulated by most shellfish, and thus harms human health through the food chain. Therefore, it is crucial to determine trace STX in seafood samples in order to ensure the safety of seafood consumption. In this study, we developed a novel indirect method for ultrasensitively determining trace STX in seafood by using CE-ICP-MS together with Eu chelate labeling. We demonstrated that diethylenetriamine-N,N,N',N″,N″-pentaacetic acid (DTPA) can couple with STX and simultaneously chelate with Eu to realize metallic labeling of STX, and thus realize the ultrasensitive quantification of trace STX with CE-ICP-MS. The proposed method has strong antiinterference ability, good stability, and extremely high sensitivity. It could be used to determine trace STX in seafood samples with an extremely low detection limit of 0.38 fmol (3.8×10 M, 100 nL sample injection) and a relative standard deviation (RSD, n = 5) <7%. The success of this study provides an alternative to precise quantification of ultra-trace STX in seafood samples, and further expands the application of ICP-MS.

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“…Since the most interesting marine toxins, particularly saxitoxin, tetrodotoxin (Figure 3), or palytoxin are difficult to produce on an industrial scale, the possibilities of using high-capacity chemical (toxin) ammunition is limited [33]. Historical experience suggests that the most likely applications of toxins are in the field of manufacturing small-arms ammunition or in aimed sabotage acts and terrorist attacks focused on food contamination [37].…”

Section: Contemporary Opinions Concerning Possibilities Of the Milmentioning

confidence: 99%

Military Importance of Natural Toxins and Their Analogs

Pitschmann

Hon

2016

Molecules

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Toxin weapon research, development, production and the ban on its uses is an integral part of international law, with particular attention paid to the protection against these weapons. In spite of this, hazards associated with toxins cannot be completely excluded. Some of these hazards are also pointed out in the present review. The article deals with the characteristics and properties of natural toxins and synthetic analogs potentially constituting the basis of toxin weapons. It briefly describes the history of military research and the use of toxins from distant history up to the present age. With respect to effective disarmament conventions, it mentions certain contemporary concepts of possible toxin applications for military purposes and the protection of public order (suppression of riots); it also briefly refers to the question of terrorism. In addition, it deals with certain traditional as well as modern technologies of the research, synthesis, and use of toxins, which can affect the continuing development of toxin weapons. These are, for example, cases of new toxins from natural sources, their chemical synthesis, production of synthetic analogs, the possibility of using methods of genetic engineering and modern biotechnologies or the possible applications of nanotechnology and certain pharmaceutical methods for the effective transfer of toxins into the organism. The authors evaluate the military importance of toxins based on their comparison with traditional chemical warfare agents. They appeal to the ethics of the scientific work as a principal condition for the prevention of toxin abuse in wars, military conflicts, as well as in non-military attacks.

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Analysis of paralytic shellfish toxins, potential chemical threat agents, in food using hydrophilic interaction liquid chromatography–mass spectrometry

Cited by 35 publications

References 29 publications

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology

Capillary electrophoresis inductively coupled plasma mass spectrometry combined with metal tag for ultrasensitively determining trace saxitoxin in seafood

Military Importance of Natural Toxins and Their Analogs

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