Analysis of Peridural Scar Formation and Its Prevention After Lumbar Laminotomy and Discectomy in Dogs

Expanded polytetrafluoroethylene membrane for the prevention of peridural fibrosis after spinal surgery: a clinical study

“…Hyaluronic acid [1] and sodium hyaluronate solution [30] have yielded some promising results in animal studies, but the number of models has been small, and statistical significance in comparisons with fat-graft results has not always been attained. In studies in rabbits, Robertson et al [28] observed some benefit in using a carbohydrate polymer to prevent peridural fibrosis.…”

“…Laminectomy membrane appears in most patients who have undergone procedures involving exposure of neural elements [31]. In some patients, it may be responsible for recurrent pain after spinal surgery that necessitates a second operation [6,8,9,30,32]. Moreover, the presence of peridural fibrosis can increase the difficulty and risks involved in re-exposure during subsequent spinal procedures [18].…”

“…Silastic (Dow Corning, Midland, Mich.) [18], Surgicel (Johnson & Johnson, New Brunswick, N.J.) [16], Gelfoam (Upjohn, Kalamazoo, Mich.) [17], polyglactin 910 [25] and more recently, polyvinyl alcohol hydrogel membrane [12], recombinant tissue-plasminogen activator gel [11], carbohydrate polymer [28] and sodium hyaluronate [30]. In general, the results achieved with these materials have been unsatisfactory, variable or preliminary.…”

The barrier effect of laminae: laminotomy versus laminectomy

“…10 However, consequently studies showed no evidence that Gelfoam prevented the ingrowth of scar tissue. 2,8,13,15 The new foamy materials such as viscous (1.9%) Na hyaluronate solution, 9 absorbable gel matrix comprising absorbable gelatine and carbohydrate polymer (ADCON-L) 5,21 reduced peridural scar tissue in the animal model. Later studies showed that autogenous free fat graft was more e ective in preventing scar tissue.…”

Bioresorbable film for the prevention of adhesion to the anterior spine after anterolateral discectomy

“…Fibrosis, which can lead to adhesions between healing tissues, is a problem that is seen in a wide array of surgical specialties. Adhesions that form postoperatively have been associated with "failed back syndrome," bowel obstruction, chronic pain, and infertility [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25] . In addition, subsequent surgeries are made more challenging and can lead to organ injury because of attachment between structures that are usually independent of one another.…”