Analysis of Peripapillary and Macular Choroidal Thickness in Eyes with Pseudoexfoliative Glaucoma and Fellow Eyes

Abstract

Purpose. To compare differences in peripapillary and macular choroidal thickness in pseudoexfoliative glaucoma (PXG) eyes, nonexfoliative fellow eyes, and normal eyes. Methods. This case-control study included 37 PXG patients (group A: 37 PXG eyes; group B: 37 nonexfoliative fellow eyes) and 37 sex-, age-, and axial length-matched healthy volunteer eyes (group C). Peripapillary and macular choroidal thickness and volume were measured in all subjects via enhanced-depth imaging-optical coherence tomography. Results. The average peripapillary (AP) choroidal thickness was (130.10 ± 46.14) μm, (131.43 ± 46.00) μm, and (147.89 ± 53.32) μm; average macular (AM) choroidal thickness was (191.72 ± 68.07) μm, (204.62 ± 69.54) μm, and (215.10 ± 45.40) μm; and average volume was (0.59 ± 0.21) μm3, (0.63 ± 0.21) μm3, and (0.65 ± 0.14) μm3 in groups A, B, and C, respectively. NIP choroidal thickness was significantly lower in groups A and B than in group C (P<0.05). TIM and TOM choroidal thickness and volume were significantly lower in group A than in group C (P<0.05). NIM, SIM, NOM, IOM, AM choroidal thickness and volume, and CSM choroidal thickness were significantly lower in group A than in group B (P<0.05). CSM, TIM, and TOM in group A and TIM, TOM choroidal thickness, and volume in group B were significantly lower than in group C (P<0.05). Conclusions. NIP choroidal thickness in PXG eyes and nonexfoliative fellow eyes and temporal macular choroidal thickness in PXG eyes were significantly lower than in normal eyes. Macular choroidal thickness (except in temporal regions) was significantly lower in PXG eyes than in nonexfoliative fellow eyes. Changes in peripapillary and macula choroidal thickness further elucidate the choroid’s role in PXG development and progression.

The impact of horizontal eye movements versus intraocular pressure on optic nerve head biomechanics: A tridimensional finite element analysis study

“…Subsequently, the peripapillary retina and choroid were included, with thicknesses of 116 μm (OCT data) and 155 μm [ 54 , 55 ], respectively, and were then extended along the scleral shell. Since MR examination of the corneoscleral shape revealed approximate symmetry between the right and left sides of the right eye, the left side of the right eye was revolutionized to obtain an initial 3D eye shell model ( Fig.…”

Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma

“…nasal quadrant of inner rings were all significantly lower in PEX patients than in healthy individuals, while there were no significant differences in the macular choroidal thickness after adjustment for age, gender, and axial length. Our previous studies [12,18] found that the macular choroidal thicknesses of PXG eyes, fellow eyes without PXG, and PEX eyes were thinner than those of normal eyes; that the macular choroidal thicknesses of PXG eyes (except on the temporal region) were thinner than those of fellow eyes without PXG; and that macular choroidal thickness was not significantly different between PXG eyes and PEX eyes. Our previous studies also found that the choroidal thicknesses of PEX eyes with normal IOP were thinner than those of normal eyes and that the macular choroidal thickness became progressively thinner as PXG progressed.…”

“…e macular thickness and volume were scanned using the EDI mode of the SD-OCT macular thickness map examination procedure. For specific measurement methods, refer to previous studies [12]. On each scanned image, the inscribed segmentation line was labeled on the retinal pigment epithelium/Bruch membrane interface, and the outer segmentation line was placed on the scleral/choroidal interface to represent the internal and external choroidal boundaries, shown in Figure 2.…”

“…Figure1: Measurement illustration of macular choroidal thickness at nine locations (reproduced from Li et al[12]). CSM: central subfield macula; NIM: nasal inner macula; SIM: superior inner macula; IIM: inferior inner macula; TIM: temporal inner macula; NOM: nasal outer macula; SOM: superior outer macula; IOM: inferior outer macula; TOM: temporal outer macula.…”

Morphological characteristics of the subfoveal choroid and their association with visual acuity in postoperative patients with unilateral congenital cataracts

“…However, they included patients after both bilateral and unilateral CC surgery, as well as those with concomitant secondary glaucoma. These patients may be complicated with choroidal abnormalities ( 19 , 20 ). In the current study, only postoperative patients with unilateral CCs without any other ocular diseases were included, eliminating the effects of age ( 21 ), systolic blood pressure ( 22 ) and concomitant diseases.…”