Analysis of peripheral blood for prostate cells after autologous transfusion given during radical prostatectomy

Stoffel, John T.; Topjian, Linda; Libertino, John A.

doi:10.1111/j.1464-410x.2005.05621.x

Cited by 39 publications

(35 citation statements)

References 21 publications

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“…[19] They used a reverse transcriptase polymerase chain reaction (RT-PCR) for their evaluation and found these cells in 88% of the patients in the immediate postoperative period. When these patients were tested at 6-week interval, they did not find any PSA-expressing cells and neither did they demonstrate any increased biochemical recurrence following the use of ICS.…”

Section: Discussionmentioning

confidence: 99%

Cost benefits of intraoperative cell salvage in radical cystectomy

Ubee¹,

Manikandan²,

Gudimetla³

et al. 2010

Indian J Urol

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Objective:We have looked into the clinical and financial benefits of using intra-operative cell salvage (ICS) as a method to reduce the amount of autologous blood transfusion (ABT) requirement for our radical cystectomy (RC) patients.Materials and Methods:Fifteen consecutive patients undergoing radical cystectomy received cell salvaged blood (ICS), while 15 did not (NCS). The cost of using the cell saver, number of homologous transfusions, survival, and recurrences were recorded and compared using paired t-test and chi-square test between the two groups. A Dideco Electa® (Sorin Group, Electa, Italy) cell saver machine was used for all the patients in the ICS group and leukocyte filters were used on the salvaged blood before the autologous transfusion.Results:The mean age was 63 years (53–72 years), 66 years (46–79 years) in ICS and NCS groups, respectively (P = 0.368). All 15 (100%) patients in the NCS group required an allogenic transfusion compared to 9/15 (60%) in the ICS group (P = 0.08). There was a significant reduction in the mean volume of allogenic blood transfused with the use of cell saver. Median follow-up was 23 and 21 months in the ICS and NCS group with 10 and 4 patients alive at last follow-up, respectively. There was a saving of 355 pounds per patient in the ICS group compared to the NCS group.Conclusion:Our initial study shows that cell savage is feasible and safe in patients undergoing radical cystectomy. It does not adversely affect the medium term outcome of patients undergoing RC and is also cost effective.

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Section: Discussionmentioning

confidence: 99%

Cost benefits of intraoperative cell salvage in radical cystectomy

Ubee¹,

Manikandan²,

Gudimetla³

et al. 2010

Indian J Urol

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“…23 Stoffel et al used a reverse transcription polymerase chain reaction assay for PSA mRNA to detect prostate cells in the cell-savaged and peripheral blood samples of patients during and following radical prostatectomy. 24 Although PSA expressing cells were found in the ICS blood of the majority of patients, they could not detect it in the peripheral circulation of any patients 3-5 weeks postoperatively with no biochemical failures.…”

Section: 22mentioning

confidence: 99%

Intraoperative red blood cell salvage and autologous transfusion during open radical retropubic prostatectomy: a cost–benefit analysis

Ubee

Kumar

Athmanathan

et al. 2011

annals

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INTRODUCTION Open radical retropubic prostatectomy (RRP) has an average blood loss of over 1,000ml. This has been reported even from high volume centres of excellence. [1][2][3][4] We have looked at the clinical and financial benefits of using intraoperative cell salvage (ICS) as a method of reducing the autologous blood transfusion requirements for our RRP patients. MATERIALS AND METHODS Group A comprised 25 consecutive patients who underwent RRP immediately prior to the acquisition of a cell saver machine. Group B consisted of the next 25 consecutive patients undergoing surgery using the Dideco Electa (Sorin Group, Italy) cell saver machine. Blood transfusion costs for both groups were calculated and compared. RESULTS The mean postoperative haemoglobin was similar in both groups (11.1gm/dl in Group A and 11.4gm/dl in Group B). All Group B patients received autologous blood (average 506ml, range: 103-1,023ml). In addition, 5 patients (20%) in Group B received a group total of 16 units (average 0.6 units) of homologous blood. For Group A the total cost of transfusing the 69 units of homologous blood was estimated as £9,315, based on a per blood unit cost of £135. This cost did not include consumables or nursing costs. CONCLUSIONS We found no evidence that autologous transfusions increased the risk of early biochemical relapse or of disease dissemination. ICS reduced our dependence on donated homologous blood.

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“…In these studies, blood was collected from the surgical field subsequent to prostatic manipulation. Stoffel performed measurements of the Prostate Specific Antigen (PSA) in subjects' blood: 1 hour prior to surgery; immediately subsequent to reinfusion of the shed blood; and 3-5 weeks following surgery (Stoffel et al 2005). He also measured the PSA level in the processed salvaged blood.…”

Section: Autotransfusion In Urologymentioning

confidence: 99%

“…Autotransfusion of washed unradiated shed blood is often employed during cystectomies and prostatectomies (Nieder et al 2004, Davis et al 2003, Ford et al 2007, Gallina et al 2007, Stoffel et al 2005, Waters et al 2004). In these studies, blood was collected from the surgical field subsequent to prostatic manipulation.…”

Section: Autotransfusion In Urologymentioning

confidence: 99%

Autotransfusion: Therapeutic Principles, Efficacy and Risks

Gemert¹

2012

Blood Transfusion in Clinical Practice

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Analysis of peripheral blood for prostate cells after autologous transfusion given during radical prostatectomy

Cited by 39 publications

References 21 publications

Cost benefits of intraoperative cell salvage in radical cystectomy

Cost benefits of intraoperative cell salvage in radical cystectomy

Intraoperative red blood cell salvage and autologous transfusion during open radical retropubic prostatectomy: a cost–benefit analysis

Autotransfusion: Therapeutic Principles, Efficacy and Risks

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