Pharmaceutical Installation at Hospital is a service unit that has a very large influence on hospital services and income from hospitals because the source of income and expenses comes from pharmaceutical installation activities in procurement to distribution. This research is a study on inventory management for Pharmaceutical supplies at Santo Yusup Boro Kulon Progo Hospital, Yogyakarta, this study aims to find a suitable inventory management calculation method that can be applied in hospitals, researchers chose ABC-VEN analysis to be applied to hospital pharmacy supply planning, as well as calculating the optimum number of orders in pharmaceutical drug supply, using EOQ calculations (Economic Order Quantity), as well as calculating when the reorder time (ROP) for the type of supply in pharmacy. This research method is a type of analytical descriptive research, the subjects of this study are the head of the service, head of finance, Head of Pharmacy installation, Head of Pharmacy and Hospital Therapy Team, other TFT members, as well as secondary data in the form of pharmaceutical sales reports, pharmacy reports in the form of opnam stock reports, reports of expired drugs, etc., data processing based on analytical descriptive using Microsoft excel. Where the results of the study from the number of pharmaceutical supplies at Santo Yusup Boro Hospital were 465 Drug items after being classified based on ABC-VEN analysis, 18 drugs entered the AV group, 20 drugs in the BV group, and 57 drugs including the CV group, after grouping based on ABC-VEN analysis in calculating the Optimum value of ordering drugs respectively, drug items, after using calculations based on ABC-VEN and EOQ analysis there was the efficiency of Rp. 22,206,511.52 in one year or there was efficiency of 41.8%. The conclusion of this study shows that the ABC VEN and EOQ methods can increase efficiency in the supply of medicines in hospital pharmacy installations, so this method is suitable for application in hospitals to manage supplies in hospitals.