Analysis of phase diagram and microstructural transitions in an ethyl oleate/water/Tween 80/Span 20 microemulsion system using high-resolution ultrasonic spectroscopy

Hickey, S; Hagan, S A; Kudryashov, Evgeny; Buckin, Vitaly

doi:10.1016/j.ijpharm.2009.12.003

Cited by 32 publications

(28 citation statements)

References 52 publications

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“…Applications of ultrasonic scattering theories allow calculations of sizes of dispersed particles from the measured values of attenuation and the physical parameters of the continuous medium and the particles. The obtained sizes in microemulsions are in good agreement with the results of other techniques (Hickey et al, 2006(Hickey et al, , 2010.…”

Section: Calculations Of Apparent Adiabatic Compressibilities From Cosupporting

confidence: 89%

“…The concentrations of water corresponding to the same transitions for titrations at different oil:surfactant ratios provide the transition lines at ultrasonic pseudo-ternary phase diagrams. The positions of the transitions between the major phases such as microemulsion, coarse emulsion, liquid crystals, biocontinous on the ultrasonic phase diagrams agree well with the phase diagrams produced by other techniques for the above systems (Hickey et al, 2006(Hickey et al, , 2010. In addition to this, a range of transitions within the microemulsion phase were observed, which allowed upgrading the phase diagrams with additional 'sub phases' within the microemulsion phase.…”

Section: Ultrasonic Phase Diagramssupporting

confidence: 80%

“…The ultrapure water (Millipore Super-Q-System) with the conductivity of 18.2 MΩ・cm −1 was used in sample preparation. Details of preparations of emulsions were described previously (Hickey et al, 2006, Hickey et al, 2010. : n-propanol (1:1, w/w)] -38% (w/w); -water -24% (w/w).…”

Section: Methodsmentioning

confidence: 99%

“…Figure 2 shows the ultrasonic titration profiles measured in three w/o microemulsion systems, IPM, AOT and EO, (described in Section 6) by stepwise additions of water into the mixture of oil & surfactant in the measuring cell of HR-US 102 spectrometer. The IPM and EO systems were studied by us previously (Hickey et al, 2006(Hickey et al, , 2010, however here we present new data on detailed titration profiles at low concentrations of water. Also, our new titration setup provided higher resolution of measurements.…”

Section: Ultrasonic Phase Diagramsmentioning

confidence: 99%

“…The technique is based on precision measurements of ultrasonic velocity and attenuation in the frequency range 1 to 20MHz. In w/o microemulsions it provided characterization of transitions between different phases, such as swollen micelles, microemulsion, coarse emulsion, liquid crystals, and evaluation of microstructural attributes of the phases, as well as characterisation of the state of water in emulsion droplets and the size of the droplets (Hickey et al, 2006(Hickey et al, , 2010. Previous applications of ultrasonic spectroscopy for analysis of microemulsions demonstrated an exceptional sensitivity of ultrasonic parameters to the structural characteristics of microemulsions and to the state of its components.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Ultrasonic Characterisation of W/O Microemulsions - Structure, Phase Diagrams, State of Water in Nano-Droplets, Encapsulated Proteins, Enzymes

Buckin¹,

Hallone²

2012

Microemulsions - An Introduction to Properties and Applications

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Section: Calculations Of Apparent Adiabatic Compressibilities From Cosupporting

confidence: 89%

Section: Ultrasonic Phase Diagramssupporting

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Section: Ultrasonic Phase Diagramsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ultrasonic Characterisation of W/O Microemulsions - Structure, Phase Diagrams, State of Water in Nano-Droplets, Encapsulated Proteins, Enzymes

Buckin¹,

Hallone²

2012

Microemulsions - An Introduction to Properties and Applications

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Application of Acoustic Spectroscopy to the Characterization of Surfactant Solutions, Emulsions, and Microemulsions: d–Limonene–Water–C₁₂EO₇–Isopropanol System

Zelenev¹

2019

J Surfact & Detergents

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The application of acoustic spectroscopy to the characterization of binary C12EO7—water system was studied. It was discovered that the size of micelles in aqueous surfactant solutions could not be determined, but it was possible to determine the size of water nanodomains existing in the surfactant‐rich systems. It was suggested that in colloidal systems, the energy of ultrasonic waves is dissipated only by interfaces existing between condensed phases. The characterization of Winsor transitions by acoustic spectroscopy in water/d‐limonene system stabilized by a mixture of nonionic surfactant and isopropyl alcohol (cosolvent) was also explored. In one study, systems with a constant d‐limonene to water weight ratio obtained in the course of titration of d‐limonene‐in‐water emulsion with increasing amounts of surfactant+alcohol were investigated. In another study, a balanced d‐limonene/water microemulsion was sequentially diluted with water and d‐limonene. The transition between Winsor I and Winsor IV systems was monitored in both cases. Droplet size distributions were calculated using different models for dispersed and continuous phase composition. It was demonstrated that the magnitude of acoustic scattering played a significant role in the ability to reliably determine droplet size distributions, and in particular to simultaneously observe nanometer‐size and micron‐size droplets in Winsor I systems. An attempt was made to account for intrinsic attenuation of surfactant and alcohol by associating them with the aqueous phase, but this approach was shown not to be applicable in the case of Winsor IV microemulsions.

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Nanoemulsion as an Effective Inhibitor of Biofilm-forming Bacterial Associated Drug Resistance: An Insight into COVID Based Nosocomial Infections

Raj

Dhamodharan

Thanigaivel

et al. 2022

Biotechnol Bioproc E

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Antibiotic overuse has resulted in the microevolution of drug-tolerant bacteria. Understandably it has become one of the most significant obstacles of the current century for scientists and researchers to overcome. Bacteria have a tendency to form biofilm as a survival mechanism. Biofilm producing microorganism become far more resistant to antimicrobial agents and their tolerance to drugs also increases. Prevention of biofilm development and curbing the virulency factors of these multi drug resistant or tolerant bacterial pathogens is a newly recognised tactic for overcoming the challenges associated with such bacterial infections and has become a niche to be addressed. In order to inhibit virulence and biofilm from planktonic bacteria such as, Pseudomonas aeruginosa , Acinetobacter baumannii , and others, stable nanoemulsions (NEs) of essential oils (EOs) and their bioactive compounds prove to be an interesting solution. These NEs demonstrated significantly greater anti-biofilm and anti-virulence activity than commercial antibiotics. The EO reduces disease-causing gene expression, which is required for pathogenicity, biofilm formation and attachment to the surfaces. Essential NE and NE-loaded hydrogel surface coatings demonstrates superior antibiofilm activity which can be employed in healthcare-related equipments like glass, plastic, and metal chairs, hospital beds, ventilators, catheters, and tools used in intensive care units. Thus, anti-virulence and anti-biofilm forming strategies based on NEs-loaded hydrogel may be used as coatings to combat biofilm-mediated infection on solid surfaces.

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Analysis of phase diagram and microstructural transitions in an ethyl oleate/water/Tween 80/Span 20 microemulsion system using high-resolution ultrasonic spectroscopy

Cited by 32 publications

References 52 publications

Ultrasonic Characterisation of W/O Microemulsions - Structure, Phase Diagrams, State of Water in Nano-Droplets, Encapsulated Proteins, Enzymes

Ultrasonic Characterisation of W/O Microemulsions - Structure, Phase Diagrams, State of Water in Nano-Droplets, Encapsulated Proteins, Enzymes

Application of Acoustic Spectroscopy to the Characterization of Surfactant Solutions, Emulsions, and Microemulsions: d–Limonene–Water–C₁₂EO₇–Isopropanol System

Nanoemulsion as an Effective Inhibitor of Biofilm-forming Bacterial Associated Drug Resistance: An Insight into COVID Based Nosocomial Infections

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Analysis of phase diagram and microstructural transitions in an ethyl oleate/water/Tween 80/Span 20 microemulsion system using high-resolution ultrasonic spectroscopy

Cited by 32 publications

References 52 publications

Ultrasonic Characterisation of W/O Microemulsions - Structure, Phase Diagrams, State of Water in Nano-Droplets, Encapsulated Proteins, Enzymes

Ultrasonic Characterisation of W/O Microemulsions - Structure, Phase Diagrams, State of Water in Nano-Droplets, Encapsulated Proteins, Enzymes

Application of Acoustic Spectroscopy to the Characterization of Surfactant Solutions, Emulsions, and Microemulsions: d–Limonene–Water–C12EO7–Isopropanol System

Nanoemulsion as an Effective Inhibitor of Biofilm-forming Bacterial Associated Drug Resistance: An Insight into COVID Based Nosocomial Infections

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Product

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About

Application of Acoustic Spectroscopy to the Characterization of Surfactant Solutions, Emulsions, and Microemulsions: d–Limonene–Water–C₁₂EO₇–Isopropanol System