Analysis of phenolic compounds and radical scavenging activity of Echinacea spp.

Pellati, Federica; Benvenuti, Stefania; Magro, Lara; Melegari, Margherita; Soragni, Fabrizia

doi:10.1016/s0731-7085(03)00645-9

Cited by 265 publications

(191 citation statements)

References 30 publications

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“…CA has been found to be the main phenolic compound in Echinacea purpurea roots (19.27 mg g -1 dw); however, it does not occur in appreciable amounts in other species, such as E. pallida and E. angustifolia (Pellati et al 2004). Commercial production from Echinacea suffers limitations owing to variables such as environmental pollutants, fungi, bacteria, and other contaminants .…”

Section: Discussionmentioning

confidence: 99%

“…Commercial production from Echinacea suffers limitations owing to variables such as environmental pollutants, fungi, bacteria, and other contaminants . As a result, discrepancies in the composition of commercial herbal medicines from Echinacea are observed (Pellati et al 2004). In addition, care must be taken to avoid the degradation of CA during storage and extraction of Echinacea (Kim et al 2000, Pellati et al 2004.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, discrepancies in the composition of commercial herbal medicines from Echinacea are observed (Pellati et al 2004). In addition, care must be taken to avoid the degradation of CA during storage and extraction of Echinacea (Kim et al 2000, Pellati et al 2004. Indeed, CA is sensitive to the enzymes present in Echinacea in moist conditions.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown to have immunostimulatory properties, promoting phagocyte activity in vitro and in vivo (Bauer et al 1989), and to inhibit hyaluronidase, a key enzyme involved in bacterial infection (Bauer 1998). In addition, CA has antiviral activity (Pellati et al 2004) and has been reported to inhibit HIV integrase and replication (King et al 1999, Lin et al 1999, Charvat et al 2006, Liu et al 2006. The activity of CA against herpes simplex virus has been demonstrated (Binns et al 2002).…”

Section: Introductionmentioning

confidence: 99%

“…The roots are used in dietary supplements, which are currently one of the best-selling herbs in North America, and have gained great attention owing to their increasing economic value (Liu et al 2006). CA was found to be the main phenolic compound in Echinacea purpurea; however, it does not occur in appreciable amounts in the other species such as E. pallida and E. angustifolia (Pellati et al 2004). The identification of any novel sources of CA is of economic interest.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The economic potential of beach-cast seagrass – Cymodocea nodosa: a promising renewable source of chicoric acid

Grignon‐Dubois

Rezzonico

2013

Botanica Marina

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Detrital and fresh specimens of the seagrass Cymodocea nodosa (Cymodoceaceae) from the Atlantic Ocean and Mediterranean Sea were screened for their phenolic content. For the first time, the major polyphenol was identified as chicoric acid (CA) by means of nuclear magnetic resonance, ultraviolet spectra, liquid chromatography/mass spectrometry, and comparison with standards. The CA content of the crude extracts was determined by quantitative high-performance liquid chromatography. The values found in the leaves ranged from 8.13 to 27.44 mg g -1 dw. The concentration was smaller in the rhizomes, with 0.31-3.70 mg g -1 dw. The phenolic profile was found to be similar whatever the geographical location in the Atlantic Ocean or the Mediterranean Sea. Considering the demonstrated therapeutic applications of CA, its high value on the nutraceutical market, and its rare occurrence in the plant kingdom, the high content found in C. nodosa detrital leaves makes this abundant biomass of interest for dietary and pharmaceutical applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The economic potential of beach-cast seagrass – Cymodocea nodosa: a promising renewable source of chicoric acid

Grignon‐Dubois

Rezzonico

2013

Botanica Marina

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Phyllobilins as a challenging diverse natural product class: Exploration of pharmacological activities

Wang

Karg

Frey

et al. 2021

Archiv der Pharmazie

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Phyllobilins are a group of chlorophyll‐derived bilin‐type linear tetrapyrroles, generated in the process of chlorophyll breakdown. Since the first phyllobilin was isolated and characterized in 1991, more and more structures of these chlorophyll catabolites were identified alongside the biochemical players involved in chlorophyll breakdown. In the meantime, phyllobilins are known to occur in a large natural structural variety, and new modifications are still being discovered. Phyllobilins have been regarded as products of chlorophyll detoxification for a very long time, hence they have been completely overlooked as a natural product class in terms of their biological role or pharmacological activity. A change of this paradigm, however, is long overdue. Here, we review the current knowledge of the pharmacological activities of phyllobilins and give an overview of the diverse structural modifications, laying the groundwork for analyzing their role(s) as active components in medicinal plants.

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A sensitive and specific liquid chromatography/tandem mass spectrometry method for determination of echinacoside and its pharmacokinetic application in rats

Yang

Wang

Hao

et al. 2009

Biomedical Chromatography

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A rapid and sensitive method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) for the determination of echinacoside in rat plasma was established and fully validated. A single step of liquid-liquid extraction with n-butanol was utilized. Chromatographic separation of the analyte and the internal standard (IS), chlorogenic acid, from the sample matrix was performed using a Capcell-MG C(18) analytical column (100 2.0 mm x 5 microm), with a gradient of acetonitrile and water containing 0.1% acetic acid as the mobile phase. Detection was performed on a triple quadrupole tandem mass spectrometer equipped with electrospray ionization source operated in negative ion selected reaction monitoring mode. The method was linear in the concentration range 10-2500 ng/mL. The deviations of both intra- and inter-day precisions (RSD) were 7.1% and the assay accuracies were within 99.2-106.5%. Echinacoside proved to be stable during sample storage, preparation and analysis when an antioxidant solution was used. The method was successfully applied to a pharmacokinetic study in rats after an intragastric administration of echinacoside (100 mg/kg). With the lower limit of quantification at 10 ng/mL, this method proved to have sufficient selectivity, sensitivity and reproducibility for the pharmacokinetic study of echinacoside.

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Analysis of phenolic compounds and radical scavenging activity of Echinacea spp.

Cited by 265 publications

References 30 publications

The economic potential of beach-cast seagrass – Cymodocea nodosa: a promising renewable source of chicoric acid

The economic potential of beach-cast seagrass – Cymodocea nodosa: a promising renewable source of chicoric acid

Phyllobilins as a challenging diverse natural product class: Exploration of pharmacological activities

A sensitive and specific liquid chromatography/tandem mass spectrometry method for determination of echinacoside and its pharmacokinetic application in rats

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