Analysis of physical and laboratory findings in nontyphoidal salmonellosis

Kayaba, Hiroyuki; Kodama, Koya; Shirayama, Kimiyuki; Kobayashi, Yoshimi; Adachi, Tomohiko; Chihara, Junichi

doi:10.1007/s10156-002-0181-y

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…Salmonella gastoenteriti ve enterik ateş olgularında değişik oranlarda tek ve tekrarlayan konvülziyonlar bildirilmiştir. 13,18,19 Çalışmamızda febril konvülziyonun NTS enfeksiyonlarını komplike ettiği görüldü. Bilinç değişik-liği ile başvuran bir hasta, ensefalopatiye neden olan ağır dehidratasyon, sepsis, menenjit, elektrolit veya metabolik bozukluk gibi sekonder faktörler dışlanarak, primer NTS ensefalopatisi olarak değerlendirildi.…”

Section: Gereç Ve Yöntemlerunclassified

Serotype Distribution, Antibiotic Resistance and Clinical Features of Salmonella Infections

Bayhan¹,

Tanır²,

Levent³

et al. 2014

Turkiye Klinikleri J Med Sci

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Section: Gereç Ve Yöntemlerunclassified

Serotype Distribution, Antibiotic Resistance and Clinical Features of Salmonella Infections

Bayhan¹,

Tanır²,

Levent³

et al. 2014

Turkiye Klinikleri J Med Sci

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“…The reason(s) for these different responses to Salmonella are not known. Factors possibly contributing to the increased mortality rate in the elderly include the presence of increased comorbidities in the elderly,8 diminished immune response20 and attenuated leucocytosis in response to infections including Salmonella 10. Additionally, ageing results in colonic tissue neurodegeneration21 and decreased responsiveness to secretory agents,22 possibly a cause of increased constipation in the elderly 23.…”

Section: Discussionmentioning

confidence: 99%

“…While infection rates in children (ie, <10 years of age) are much higher than in the rest of the population, older individuals (ie, >60 years of age) are much more likely to succumb to infection 8 9 10 11. Furthermore, the signs and symptoms of S typhimurium infection vary between these age groups.…”

mentioning

confidence: 99%

Age-dependent differences in galanin-dependent colonic fluid secretion after infection with Salmonella typhimurium

Royan

Blunier

Hecht

et al. 2009

Gut

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Epithelial cells lining the colon do not normally express galanin type 1 receptors (Gal1Rs). However, subsequent to infection with enteric pathogens such as Salmonella typhimurium, the Gal1R is rapidly upregulated in colonocytes where it contributes to the excess fluid production associated with diarrhoea. Humans infected with non-typhoid Salmonella respond differently according to age: infants develop diarrhoea but not bacteraemia and survive, while the elderly become bacteraemic and die. Thus the aim of this study was to determine if age-related differences exist in response to S typhimurium infection in mice, and whether these differences are due to altered Gal1R expression. Wild-type C57BL/6J mice that were 2 and 15 months old, as well as 2-month-old Gal1R knockout mice, were infected by gavage. Young wild-type mice expressed Gal1R in response to infection, had increased colonic fluid secretion, low rates of bacteraemia and survived. In contrast, 15-month-old wild-type mice expressed fewer Gal1Rs in response to infection, had attenuated increases in colonic fluid secretion, high rates of bacteraemia and died. A similar profile was noted in 2-month-old Gal1R knockout mice. Addition of polyethylene glycol to the drinking water of 15-month-old wild-type mice increased colonic fluid secretion and reduced rates of bacteraemia to those observed in 2-month-old wild-type mice and eliminated fatalities. The difference in response to S typhimurium infection with age may be due, at least in part, to decreased Gal1R expression and decreased amounts of colonic fluid secretion.

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“…2,3 The present report indicates that cases suggestive of infection with Salmonella or other enteric pathogens sometimes resemble acute appendicitis and that acute appendicitis sometimes complicates nontyphoidal salmonellosis, making surgical intervention necessary. [4][5][6][7][8][9] It is usually assumed that intraoperative bacteriology is of little utility in appendicitis. 10 In our opinion, intraoperative cultures are recommended in the context of appendicitis with atypical presentation such as diarrhea.…”

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confidence: 99%

Salmonella enterica serovar Israel causing perforating appendicitis

Bartoli

Guerra

Dolina

et al. 2010

International Journal of Infectious Diseases

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Salmonella enterica serovar Israel causing perforating appendicitis Surgical complications, either intestinal hemorrhage or intestinal perforation, sometimes occur in typhoidal salmonellosis. 1 We report here the unusual case of a child who developed Salmonella Israel appendicitis.An otherwise healthy 12-year-old Swiss girl experienced fever, mild abdominal pain, non-bilious vomiting, and especially watery diarrhea for one week without consulting a physician. With the severity of her disturbances increasing, she was brought to our hospital in very poor condition, with fever and rebound tenderness. Laparotomy revealed a large amount of turbid, cloudy fluid and a perforated appendix. The intraoperative cultures were positive for Salmonella enterica serovar Israel. Once the results of the culture were known, the antibiotic coverage was changed to ceftriaxone. Her subsequent clinical course was uneventful.Diarrhea and appendicitis rarely coincide, and even rebound tenderness in the presence of diarrhea is almost invariably secondary to an acute intestinal infection. 2,3 The present report indicates that cases suggestive of infection with Salmonella or other enteric pathogens sometimes resemble acute appendicitis and that acute appendicitis sometimes complicates nontyphoidal salmonellosis, making surgical intervention necessary. [4][5][6][7][8][9] It is usually assumed that intraoperative bacteriology is of little utility in appendicitis. 10 In our opinion, intraoperative cultures are recommended in the context of appendicitis with atypical presentation such as diarrhea. In point of fact, antibiotic coverage after perforated appendicitis is often inappropriate for salmonellosis. 2,3 Conflict of interest: No conflict of interest to declare.

show abstract

Analysis of physical and laboratory findings in nontyphoidal salmonellosis

Cited by 3 publications

References 17 publications

Serotype Distribution, Antibiotic Resistance and Clinical Features of Salmonella Infections

Serotype Distribution, Antibiotic Resistance and Clinical Features of Salmonella Infections

Age-dependent differences in galanin-dependent colonic fluid secretion after infection with Salmonella typhimurium

Salmonella enterica serovar Israel causing perforating appendicitis

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