Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer

Ito, Chie; Nishizuka, Satoshi; Ishida, Kazuyuki; Uesugi, Noriyuki; Sugai, Tamotsu; Tamura, Gen; Koeda, Keisuke; Sasaki, Akira

doi:10.1016/j.jss.2017.01.018

Cited by 29 publications

(20 citation statements)

References 59 publications

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“…Similarly, the mutation, frequency, and hotspot pattern of PIK3CA gene in gastric cancer tissues are also specific topics. However, so far, there is no significant correlation between the mutation of PIK3CA gene and the clinicopathological features of gastric cancer 24 , 26 , 27 . Gene amplification is another primary mechanism of oncogene activation.…”

Section: Discussionmentioning

confidence: 99%

MiR-152-5p as a microRNA passenger strand special functions in human gastric cancer cells

You¹,

Xing²,

Ji³

et al. 2018

Int. J. Biol. Sci.

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Gastric cancer (GC) is one of the most common malignancies with high mortality rate. MiR-152 may exert the function of tumor suppressor by regulating its target gene, including PIK3CA. Nevertheless, all of the described functions are referred explicitly to miR-152-3p, while miR-152-5p as a passenger strand is poorly realized and entirely ignored. We previously selected miR-152-5p as a candidate using cell migration inhibition screening for GC cells and predicted that miR-152-5p might also target PIK3CA. In this study, we found an abnormal proportion of miR-152-3p / miR-152-5p in GC (gastric cancer) tissues and cells and demonstrated that miR-152-5p had poorer stability in GC cells, revealing the possibility that miR-152-5p is abnormally "suppressed" in gastric cancer. We also investigated and confirmed the role of miR-152-5p in GC by a series of experiments, and found that miR-152-5p modulated cell viability, migration, invasion, and cell-cycle progression of human GC cells, and also inhibited tumor growth and metastasis in vivo partially by targeting PIK3CA. More interestingly, it was proved that miR-152-3p and miR-152-5p had synergistic effects on the inhibition of PIK3CA in GC cells. The results of this study suggest that miR-152-5p may act as a tumor suppressor in SGC-7901 gastric cancer cells via targeting PIK3CA. Further, the study provides a novel insight into the roles of miRNA* during carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

MiR-152-5p as a microRNA passenger strand special functions in human gastric cancer cells

You¹,

Xing²,

Ji³

et al. 2018

Int. J. Biol. Sci.

View full text Add to dashboard Cite

show abstract

“…But one research reveals that PI3K/AKT pathway genetic mutations are found in 69 (16%) of the 431 GC patients including PIK3CA (13.2%) and PTEN (4.0%), as well as PIK3CA amplifications are found in 206 (47.8%) of the patients [107]. Another research shows that advanced GC patient have more frequency of PIK3CA mutations in codon 545 than in codon 1047 [108]. A large number of researches confirm that besides NETO2, UFM1, STIL, LEMD1, SPP1 To study the side effects and BD of MK2206 and lapatinib ditosylate when given together with trastuzumab in treating patients with locally advanced or metastatic GC, or GEC that cannot be removed by surgery…”

Section: Deregulation Of the Pi3k/akt Pathway In Digestive System Tumorsmentioning

confidence: 99%

Role of PI3K/AKT pathway in cancer: the framework of malignant behavior

et al. 2020

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Given that the PI3K/AKT pathway has manifested its compelling influence on multiple cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in various human cancers. We state the abnormalities of PI3K/AKT pathway in different cancers, which are closely related with tumorigenesis, proliferation, growth, apoptosis, invasion, metastasis, epithelial-mesenchymal transition, stem-like phenotype, immune microenvironment and drug resistance of cancer cells. In addition, we investigated the current clinical trials of inhibitors against PI3K/AKT pathway in cancers and found that the clinical efficacy of these inhibitors as monotherapy has so far been limited despite of the promising preclinical activity, which means combinations of targeted therapy may achieve better efficacies in cancers. In short, we hope to feature PI3K/ AKT pathway in cancers to the clinic and bring the new promising to patients for targeted therapies.

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“…It has been reported that no ethnic differences in PIK3CA mutation frequencies exist, whereas the PIK3CA mutations are predominantly found in 80% of Epstein Barr virus (EBV) positive subgroups[ 45 ]. A recent study pointed that p-AKT negative tumors are more malignant than p-AKT positive but are rescued by the adjuvant chemotherapy for GC patients undergoing gastrectomy regardless of the PIK3CA mutation status[ 46 ].…”

Section: Current Topics Of Biomarkers In Gcmentioning

confidence: 99%

Biomarkers of gastric cancer: Current topics and future perspective

Matsuoka

Yashiro

2018

WJG

376

266

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Gastric cancer (GC) is one of the most prevalent malignant types in the world and an aggressive disease with a poor 5-year survival. This cancer is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Although the incidence is declining, the outcome of patients with GC remains dismal. Thus, the detection at an early stage utilizing useful screening approaches, selection of an appropriate treatment plan, and effective monitoring is pivotal to reduce GC mortalities. Identification of biomarkers in a basis of clinical information and comprehensive genome analysis could improve diagnosis, prognosis, prediction of recurrence and treatment response. This review summarized the current status and approaches in GC biomarker, which could be potentially used for early diagnosis, accurate prediction of therapeutic approaches and discussed the future perspective based on the molecular classification and profiling.

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Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer

Cited by 29 publications

References 59 publications

MiR-152-5p as a microRNA passenger strand special functions in human gastric cancer cells

MiR-152-5p as a microRNA passenger strand special functions in human gastric cancer cells

Role of PI3K/AKT pathway in cancer: the framework of malignant behavior

Biomarkers of gastric cancer: Current topics and future perspective

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